Abstract: The present disclosure provides a class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A, X, R2, R2?, R3, R4, R5, R6, and R7 of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A? plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, and other central nervous system conditions.

Abstract: The present disclosure provides a class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A, X, R2, R2?, R3, R4, R5, R6, and R7 of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A? plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, and other central nervous system conditions.

Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A7, and each of Ra, Rb, R1, R2, R3, R8 R9 and R10 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A? plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions.

Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A7, and each of Ra, Rb, R1, R2, R3, R8 R9 and R10 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A? plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions.

Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

Abstract: Biomarkers and methods using the biomarkers for prognosis of renal cancer in a patient are provided.

Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

Abstract: A measuring tape apparatus includes a housing, and a tape disposed in the housing and having measuring indicia thereon. The tape has a first end inside of the housing, and a free end which is slidably removable from the housing. An L-shaped end flange is attached to the free end of the tape, for use in aligning the tape with a work piece. The end flange includes a connection section which is oriented substantially parallel to the tape, and an alignment section, substantially perpendicular to the connection section, for contacting an edge portion of a work piece. Rivets are provided to connect the end flange to the tape. The connection section also has a slot formed therein, extending laterally across the flange. The slot is adapted to receive a tip portion of a knife or marking implement therethrough, and may have a side edge which is substantially parallel to the alignment section.

Abstract: ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include compounds of formula (I): Z-???(I) Wherein Z is a zinc coordinating moiety and ? is an amino-acid mimicking moiety, and pharmaceutically acceptabale salts thereof. Methods of using the inhibitors and pharmaceutical compositions containing the inhibitors to treat a body weight disorder, to decrease appetite, to increase muscle mass, to decrease body fat, to treat diabetes and to treat a state associated with altered lipid metabolism, are also described.

Abstract: ACE-2 modulating compounds for the treatment of body weight disorders are disclosed. Methods of using the compounds and pharmaceutical compositions containing the compounds are also claimed.

Abstract: ACE-2 inhibiting compounds are disclosed. These compounds include compounds of formula (IV): wherein the variables are as described in the specification. Pharmaceutical compositions containing the compounds are also discussed. The pharmaceutical compositions may contain an effective amount of a compound of the invention to treat ACE-2 associated disorders such as a blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder.

Abstract: Compositions for use in the treatment of complex waste liquids are disclosed. The complex waste liquids may include organics, organic polymers, and heavy metals. The composition is a solution comprising, in relative percentages, from about 2 moles to about 3 moles Me.sup.III, from about 1 mole to about 3 moles Me.sup.II, and from about 4 moles to about 5 moles monovalent or divalent anionic groups. In such a composition Me.sup.III is selected from the group consisting of Fe.sup.+3 and Al.sup.+3 ; whereas Me.sup.II is selected from the group consisting of Mg.sup.+2 and Ca.sup.+2. The anionic groups are generally selected from the group consisting of Cl.sup.-, NO.sub.3.sup.-, and SO.sub.4.sup.2-.

Abstract: A shelving unit made of vertical end panels, horizontal shelves, cornice boards and toekicks secured together in a rigid and accurate assembly of parts. The shelf at the midpoint in the height of the end panels is connected to the end panels by shelf support locking pins which restrict the end panels from flexing in or out. Locking pin brackets have locking pins to pull the cornice and toekick tight with respect to the end panels, providing a strong and accurate connection between the parts.

Abstract: A method for treating liquid wastes containing photoresist polymers and heavy metals is disclosed. The method includes adding to the liquid wastes an aqueous solution of water soluble FE.sup.+3 and Al.sup.+3 salts at a pH in the range of from about 0.1 to 1.0, and a water soluble salt of Mg.sup.+2 or Ca.sup.+2. The ratio of the amount of the Fe.sup.+3 and Al.sup.+3 to the amount of the Mg.sup.+2 or Ca.sup.+2 is in the range of from 2 to 3 moles to 1 to 3 moles. A precipitate containing the heavy metals and photoresist polymers is formed.

Abstract: A releasable fabric joining apparatus is disclosed, comprising a first piece of material which includes a planar body substrate and a planar loop substrate which has a first loop substrate secured coplanar with the planar body substrate. The planar loop substrate also includes a second loop substrate surface formed of woven fabric having plural loops of thread. A second piece of material forms another part of the apparatus, and has at least one surface with a grip face provided with plural, outwardly-extending filamentary hooks releasably received by the plural loops of thread. In a preferred embodiment, the first piece of material is woven fabric, and the second piece of material is loop-type Velcro. The present invention may be used in many different embodiments, such as in a non-slip shoelace, baby bib, and in other applications wherein a need exists to releasably secure to pieces of fabric while ensuring that the joined pieces have high resistance to shear stress.

Abstract: An APL environment includes the usual workspaces plus so-called packaged workspaces. The disclosed packaged workspaces are load modules created from saved workspaces. An active APL workspace can access a loaded copy of the packaged workspaces using external names of named objects in a packaged workspace rather than internal names of its own named objects. Program execution associated with the packaged workspaces is controlled through a copy of the packaged workspace name table stored in the active workspace accessing the read only packaged workspace. Access to packaged workspaces not only can be concatenated from other packaged workspaces, but also can be shared among a plurality of active workspaces.

Abstract: A foldable work table having two pairs of legs, each pair being pivotal intermediate the ends thereof to move between a support position in a generally X-shape and a storage position where both legs of a pair are substantially parallel. The pairs of legs are longitudinally spaced apart. A first bracing member extends between each of one leg of a pair and a second bracing member extends between each of the other legs of a pair. A pair of elongated table members are hinged together along their length, each of the table members also being hinged to one of the bracing members, whereby the table members may pivot between a horizontal support position with the leg pairs in a support position and a storage position where the table members are in a generally vertical position and each leg pair is in a stowage position substantially parallel to each other.

Abstract: A method for executing external processes and for accessing external data from within an interactive language workspace. The workspace task referencing the external processes or data is synchronized and locked until the process is completed or the data referenced. The method steps provide establishing a message interface and utilize coercion of arguments in a dynamic environment. This permits, for instance, the invocation of a FORTRAN language process or from within an APL workspace and a return of information from said external processor without terminating the APL workspace.

Abstract: A corner casting of the type used for lifting and moving containers is mounted to auxiliary apparatus such as a spreader for holding deckloading cargo. The corner casting is configured for actuating a crank upon the penetration of the lifting hook. When the hook penetrates at the top hole of the corner casting, a pedal pad is depressed. The pedal pad in turn is attached to a lever arm having a pivot at one end, the pedal pad at the other end and a pivotally attached spring bias rod therebetween. Upon twistlock penetration, the spring biased rod produces crank rotation at a protruding eccentric from a crank. By using the spring biased rod rotary motion can be imparted to the crank so that lifting of the spreaders effects automated container release in the case of the disclosed equalizer.