Abstract: Robotic systems for orthopedic surgery are provided. The robotic systems may include at least first and second motors coupled to each other. An output shaft of one of the motors may be connectable to a surgical tool guide. An output shaft of another of the motors may be coupled to a portion of a ball and socket joint. A corresponding portion of the ball and socket joint may be coupled to a bone mount which may be attached to a bone to mount the first and second motors to bone for performing orthopedic surgical procedures.

Abstract: The present disclosure provides a class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A, X, R2, R2?, R3, R4, R5, R6, and R7 of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A? plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, and other central nervous system conditions.

Abstract: The present disclosure provides a class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A, X, R2, R2?, R3, R4, R5, R6, and R7 of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A? plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, and other central nervous system conditions.

Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A7, and each of Ra, Rb, R1, R2, R3, R8 R9 and R10 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A? plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions.

Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A7, and each of Ra, Rb, R1, R2, R3, R8 R9 and R10 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A? plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions.

Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

Abstract: Biomarkers and methods using the biomarkers for prognosis of renal cancer in a patient are provided.

Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

Abstract: HVOF torches introduce fuel and oxidizer reactants into a central passage so as to form a concentric stream having an axial stream of oxidizer surrounded by an annular stream of fuel that is positioned against a sidewall that bounds the central passage. The fuel can be introduced so as to swirl about the axial stream of oxidizer. The torch can be formed by a body having the central passage therethrough and an insert residing in the central passage and having an oxidizer passage therethrough. A portion of the insert can have a reduced cross section so as to form an annular fuel chamber, from which the flow of fuel into a passage first section is restricted so as to distribute the fuel against the sidewall. The torch can be provided with a cooling jacket to prevent damage to the body.

Abstract: HVOF torches introduce fuel and oxidizer reactants into a central passage so as to form a concentric stream having an axial stream of oxidizer surrounded by an annular stream of fuel that is positioned against a sidewall that bounds the central passage. The fuel can be introduced so as to swirl about the axial stream of oxidizer. The torch can be formed by a body having the central passage therethrough and an insert residing in the central passage and having an oxidizer passage therethrough. A portion of the insert can have a reduced cross section so as to form an annular fuel chamber, from which the flow of fuel into a passage first section is restricted so as to distribute the fuel against the sidewall. The torch can be provided with a cooling jacket to prevent damage to the body.

Abstract: A torch introduces oxidizer into a passage so as to swirl the oxidizer about a central axis, while fuel is introduced at a location spaced apart from the central axis, where the swirling action of the oxidizer is strong, resulting in rapid mixing of the fuel and oxidizer. In practicing the method, the length of a bore through which the fuel and oxidizer pass is maintained short enough that a sheath of unmixed oxidizer surrounds the combusting mixed fuel and oxidizer, eliminating any need for water cooling. The lengths of torches of the present invention can be significantly shorter than those of the prior art, making the torches well suited for use in confined spaces, and the torches have been found to allow spraying materials at a greater rate than torches of the prior art. The reduced length also facilitates introducing into the passage material to be spray-coated.

Abstract: The present method and apparatus for producing a supersonic jet stream introduce an oxidizer in such a manner as to create a vortex, which is then restricted. Fuel is introduced into a reduced pressure eye of the vortex, forming a stratified composite stream of gases with unmixed oxidizer surrounding an inner mixture of fuel and oxidizer. This stratified composite stream is passed down a tube that exhausts to a low pressure environment. The combined fuel and oxidizer in the stratified stream is ignited to provide a high-velocity stream of combustion products. The outer layer of unmixed oxidizer in the vortex shields the tube and reduces or eliminates the need for additional cooling.

Abstract: The present method and apparatus for producing a supersonic jet stream introduce an oxidizer in such a manner as to create a vortex, which is then restricted. Fuel is introduced into a reduced pressure eye of the vortex, forming a stratified composite stream of gases with unmixed oxidizer surrounding an inner mixture of fuel and oxidizer. This stratified composite stream is passed down a tube that exhausts to a low pressure environment. The combined fuel and oxidizer in the stratified stream is ignited to provide a high-velocity stream of combustion products. The outer layer of unmixed oxidizer in the vortex shields the tube and reduces or eliminates the need for additional cooling.

Abstract: A measuring tape apparatus includes a housing, and a tape disposed in the housing and having measuring indicia thereon. The tape has a first end inside of the housing, and a free end which is slidably removable from the housing. An L-shaped end flange is attached to the free end of the tape, for use in aligning the tape with a work piece. The end flange includes a connection section which is oriented substantially parallel to the tape, and an alignment section, substantially perpendicular to the connection section, for contacting an edge portion of a work piece. Rivets are provided to connect the end flange to the tape. The connection section also has a slot formed therein, extending laterally across the flange. The slot is adapted to receive a tip portion of a knife or marking implement therethrough, and may have a side edge which is substantially parallel to the alignment section.

Abstract: ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include compounds of formula (I): Z-???(I) Wherein Z is a zinc coordinating moiety and ? is an amino-acid mimicking moiety, and pharmaceutically acceptabale salts thereof. Methods of using the inhibitors and pharmaceutical compositions containing the inhibitors to treat a body weight disorder, to decrease appetite, to increase muscle mass, to decrease body fat, to treat diabetes and to treat a state associated with altered lipid metabolism, are also described.

Abstract: In a thermal spray process, a wire is fed into a flame-jet to heat said wire to the melting point, atomize and projected high velocity the droplets so formed against a surface to buildup a coating of material on the surface. The wire is fed into the flame by aligning the cast-plane of the wire with the flame-jet by using a tubular member formed into a circular shape to provide sufficient length to guide wire and to provide the necessary twist amount to the wire to align the cast-plane with the axis of the flame-jet.

Abstract: ACE-2 modulating compounds for the treatment of body weight disorders are disclosed. Methods of using the compounds and pharmaceutical compositions containing the compounds are also claimed.

Abstract: ACE-2 inhibiting compounds are disclosed. These compounds include compounds of formula (IV): wherein the variables are as described in the specification. Pharmaceutical compositions containing the compounds are also discussed. The pharmaceutical compositions may contain an effective amount of a compound of the invention to treat ACE-2 associated disorders such as a blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder.

Abstract: A supersonic flame jet device includes a body having an entry portion of relatively small cross-sectional area, an expanding supersonic nozzle section and a cylindrical duct of extended length connected in series with each other. In using the device, an oxidant at high pressure is introduced into the entry passage wherein the flow is increased to sonic velocity. The sonic velocity flow of oxidant is then introduced into the passage of expanding cross-section in the direction of the gas flow while introducing a fuel to be burned into the flow of the oxidant. The velocity of flow of the oxidant or the oxidant and the fuel is then increased to supersonic velocity prior to entry into the extended duct of constant cross-sectional area where a shock is produced to stabilize flame reactions along the extended duct length whereby a supersonic flame jet will exit the extended duct.