Abstract: In alternative embodiments, provided are methods for treating and ameliorating a cancer, or recurrence of a cancer such as acute myeloid leukemia (AML) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 (or rebecsinib) and second drug such as an ATP-competitive protein tyrosine kinase inhibitor such as dasatinib. In alternative embodiments, provided are methods for the in vivo inhibition of myeloproliferative neoplasm (MPN) or AML stem cell propagation comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug. In alternative embodiments, provided are methods for the in vivo inhibition pre-leukemia stem cell (pre-LSC) transformation into leukemia stem cells (LSCs) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug.

Abstract: This invention comprises a grid structure that with the addition of panels and a panel holding means, and the further addition of a gutter and downspout provides an effective under-deck water shedding system where the grid and panel components generally are set or slid into place and generally can be lifted or slid out of place for adjustment, maintenance or removal.

Abstract: This invention comprises a grid structure that with the addition of panels and a panel holding means, and the further addition of a gutter and downspout provides an effective under-deck water shedding system where the grid and panel components generally are set or slide into place and generally can be lifted or slide out of place for adjustment, maintenance or removal.

Abstract: This invention comprises a grid structure that with the addition of panels and panel holding components, and the further addition of a gutter and downspout provides an effective under-deck water shedding system where the grid and panel components generally are set or slid into place and generally can be lifted or slid out of place for adjustment, maintenance or removal.

Abstract: Disclosed are a bumper retaining device (20) and a latch holding device (40) which facilitate the safe use of pressure mounted security gates (10) commonly used for children or pets. The bumper retaining device (20) consists of a plate (22) with a hollow (24) on the upper side, configured to receive and retain frictional bumpers (14) of the security gate (10). Two bumper retaining devices (20), one on each side of a passageway, are to be positioned to receive two upper bumpers (14). The bumper retaining device (20) keeps the security gate (10) from being dislodged. A latch holding device (40) keeps the latch (30), which controls width and pressure of the security gate (10), from falling out of adjustment. A kit is assembled of the inventive devices for easy installation by a home owner.