Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating alpha-1 antitrypsin deficiency (AATD) are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating phenylketonuria (PKU) are described.

Abstract: A process of augmenting images of incident scenes with object descriptions retrieved from an audio stream. In operation, an electronic computing device detects an object of interest in an image captured corresponding to an incident scene and identifies an audio stream linked to an incident identifier of an incident that occurred at the incident scene. The electronic computing device then determines whether the audio stream contains an audio description of the detected object of interest. When it is determined that the audio stream contains the audio description of the detected object of interest, the electronic computing device generates a visual or audio prompt corresponding to the audio description of the detected object of interest and plays back the visual or audio prompt via a corresponding display or audio-output component communicatively coupled to the electronic computing device.

Abstract: The User Interface Portlet Data Cascade Actuator Apparatuses, Methods and Systems (“UIPDCA”) transforms database data sets, user interface widget data selections inputs via UIPDCA components into cascading UI subsequent views data selections and channel outputs. In one embodiment, the UIPDCA may include a data cascade user interface view apparatus. The UIPDCA's processor issues instructions from a UI view component to generate and broadcast a first event message that specifies a data source parameter associated with a user selection and the channel associated with the UI view component. The UIPDCA's processor issues instructions from a subsequent UI view component to update UI widget elements based on result of executing a query modified using parameters specified in the first event message, and to generate and broadcast a second event message that specifies a data source parameter associated with a default selection and the channel associated with the subsequent UI view component.

Abstract: A system and method for implementing a flexible interrupt mechanism in an electronic system includes a processor that may initially execute an initialization routine for performing an interrupt configuration procedure. The foregoing interrupt configuration procedure may preferably be initiated when the processor programs a configuration register with certain selectable interrupt parameters that may be utilized to flexibly configure an interrupt module in the electronic system. Internal and external interrupt sources may then subsequently provide various interrupts to the configured interrupt module which may responsively detect and route the interrupts to the processor based upon interrupt information provided during the foregoing interrupt configuration procedure. The processor may then effectively service the interrupts during appropriate interrupt servicing procedures by utilizing corresponding interrupt handler routines.

Abstract: A system and method for implementing a flexible interrupt mechanism in an electronic system includes a processor that may initially execute an initialization routine for performing an interrupt configuration procedure. The foregoing interrupt configuration procedure may preferably be initiated when the processor programs a configuration register with certain selectable interrupt parameters that may be utilized to flexibly configure an interrupt module in the electronic system. Internal and external interrupt sources may then subsequently provide various interrupts to the configured interrupt module which may responsively detect and route the interrupts to the processor based upon interrupt information provided during the foregoing interrupt configuration procedure. The processor may then effectively service the interrupts during appropriate interrupt servicing procedures by utilizing corresponding interrupt handler routines.

Abstract: A system and method for efficiently performing a data transfer operation in an electronic system preferably includes a processor that may initially create a DMA structure in a block transfer memory device. The DMA structure may preferably include one or more command structures for performing DMA data transfer operations. The processor may subsequently program local control registers of a DMA engine with selected DMA transfer information in response to a DMA data transfer requirement. The processor may then instruct the DMA engine to perform the required DMA data transfer operation. Next, the DMA engine may responsively copy one or more of the command structures from the block transfer memory device into local command registers that are coupled to the DMA engine. The DMA engine may then reference the foregoing control registers and command registers to thereby efficiently perform one or more DMA data transfer operations.