Abstract: The invention relates to a method for screening a library of peptide ligands, said library comprising a plurality of polypeptides covalently linked to a molecular scaffold at two or more amino acid residues, comprising the steps of displaying said library of peptide ligands in a genetic display system, wherein the polypeptide comprises two or more reactive groups which form a covalent linkage to the molecular scaffold, and at least one loop which comprises a sequence of amino acids subtended between two of said reactive groups; exposing the peptide ligands to one or more cells which display one or more target molecules on the cell surface; and screening the peptide ligands for binding against the target, and selecting the ligands which bind to the target.

Abstract: Direct data transfer between devices having a shared bus may be implemented with reduced involvement from a controller associated with the devices. A controller, a source memory device, and a target memory device may be coupled with a shared bus. The controller may identify a source address at the source memory device for data to be transferred to the target memory device. The controller also may identify a target address in the target memory device, and initiate a data transfer directly from the source to the target through a command that is received at both the source and the target memory device. In response to the command, the source memory device may read data out to the bus, and the target memory may read the data from the bus and store the data starting at the target address without further commands from the controller.

Abstract: Various embodiments provide systems and method for hybrid monitoring of individuals using both a combination of a user attached monitor device and a user detached monitor device.

Abstract: The present invention relates to a method for determining an extent of cyclisation of a peptide ligand displayed on a genetic display system, wherein the peptide ligand comprises a polypeptide covalently linked to a molecular scaffold at two or more amino acid residues, comprising the steps of exposing the polypeptide displayed on the genetic display system to the molecular scaffold, wherein said polypeptide comprises two or more peptide reactive groups on said two or more amino acid residues which form covalent bonds with the molecular scaffold at two or more scaffold reactive groups, to give the peptide ligand; removing unreacted molecular scaffold from the genetic display system; exposing the peptide ligand displayed on the genetic display system to a first probe, wherein the first probe binds to a first unconjugated reactive group on the peptide ligand; and measuring the first unconjugated reactive group on the peptide ligand.

Abstract: The present invention provides for an intrinsically safe powered wearable device including a power source connector for physical and electrical connection and disconnection for replacement of a power source on the device in a hot-pluggable manner.

Abstract: A composition provides superior deposition of benefit agent to hair, said composition comprising: (i) 0.01 to 10 wt % of a linear cationic conditioning primary surfactant; selected from structure 1 and mixtures thereof: Structure 1 wherein: R1 comprises a linear alkyl chain having a carbon-carbon chain length of from C16 to C24, preferably C18 to C22; R2 comprises a proton or a linear alkyl chain having a carbon-carbon chain length of from C1 to C4, preferably C1 to C2 or a benzyl group; and X is an organic or inorganic anion; (ii) 0.1 to 10 wt % of a linear fatty material; (iii) a particulate benefit agent selected from conditioning actives and mixtures thereof; (iv) 0.

Abstract: Direct data transfer between devices having a shared bus may be implemented with reduced involvement from a controller associated with the devices. A controller, a source memory device, and a target memory device may be coupled with a shared bus. The controller may identify a source address at the source memory device for data to be transferred to the target memory device. The controller also may identify a target address in the target memory device, and initiate a data transfer directly from the source to the target through a command that is received at both the source and the target memory device. In response to the command, the source memory device may read data out to the bus, and the target memory may read the data from the bus and store the data starting at the target address without further commands from the controller.

Abstract: Improved particulate benefit agent deposition onto hair is achieved with a corn position comprising: (i) a linear, cationic conditioning surfactant; (ii) a linear fatty material; (iii) a particulate benefit agent (iv) a branched cationic co-surfactant, selected from structure 1, wherein the molar ratio of branched cationic co-surfactant (iv) to linear cationic surfactant (i) is in the range of from 1:20 to 1:1.

Abstract: A conditioning composition provides superior deposition of benefit agent to hair, said composition comprising: (i) 0.01 to 10 wt % of a linear cationic conditioning primary surfactant; selected from structure 1 and mixtures thereof: (ii) 0.1 to 10 wt % of a linear fatty material; (iii) a particulate benefit agent selected from conditioning actives and mixtures thereof; (iv) 0.01 to 5 wt %, of a linear cationic co-surfactant, selected from structure 2 and mixtures thereof; and wherein the molar ratio of linear cationic co-surfactant (iv) to linear cationic conditioning primary surfactant (i) is in the range of from 1:20 to 1:1.

Abstract: A conditioning composition results in improved particulate benefit agent deposition on to hair, said composition comprising: (i) 0.01 to 10 wt % of a linear cationic conditioning primary surfactant; selected from structure 1 and mixtures thereof; (ii) 0.1 to 10 wt % of a linear fatty material; (iii) a particulate benefit agent selected from conditioning actives and mixtures thereof; (iv) 0.01 to 5 wt % of a linear di-alkyl cationic co-surfactant, selected from structure 2 and mixtures thereof.

Abstract: A composition provides superior deposition of benefit agent to hair, said composition comprising: (i) 0.01 to 10 wt % of a linear cationic conditioning primary surfactant; selected from structure 1 and mixtures thereof: Structure 1 wherein: R1 comprises a linear alkyl chain having a carbon-carbon chain length of from C16 to C24, preferably C18 to C22; 10. R2 comprises a proton or a linear alkyl chain having a carbon-carbon chain length of from C1 to C4, preferably C1 to C2 or a benzyl group; and X is an organic or inorganic anion; (ii) 0.1 to 10 wt % of a linear fatty material; 15 (iii) a particulate benefit agent selected from conditioning actives and mixtures thereof; (iv) 0.

Abstract: A conditioning composition provides superior deposition of benefit agent to hair, said composition comprising: (i) 0.01 to 10 wt % of a linear cationic conditioning primary surfactant; selected from structure 1 and mixtures thereof: Structure 1 (ii) 0.1 to 10 wt % of a linear fatty material; (iii) a particulate benefit Structure 1 (iv) 0.01 to 5 wt %, of a linear cationic co-surfactant, selected from structure 2 and Structure 2 mixtures thereof Structure 2.

Abstract: The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of PD-L1. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by PD-L1.

Abstract: A composition comprising: (i) 0.01 to 10 wt % of a linear, cationic conditioning surfactant; (ii) 0.1 to 10 wt % of a linear fatty material; (iii) a particulate benefit agent; (iv) 0.

Abstract: A system and a method for determining a high oil consumption in a gas turbine engine of an aircraft are provided. The method includes determining one or more engine and aircraft conditions. The one or more engine and aircraft conditions includes at least one of an oil quantity, an oil temperature, an oil pressure, an engine speed, an aircraft altitude, and an aircraft attitude. The method further includes determining a trend in oil conditions based on at least the one or more engine and aircraft conditions. The trend in oil conditions provides at least one of a rate of consumption of oil or a time duration of remaining oil. The method further includes determining the high oil consumption based on a comparison of the trend in oil conditions with a threshold or a comparison model.

Abstract: The present invention relates to polypeptides which are covalently bound to aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of PD-L1. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by PD-L1.

Abstract: A composition comprising: (i) 0.01 to 10 wt % of a linear, cationic conditioning surfactant; (ii) 0.1 to 10 wt % of a linear fatty material; (iii) a particulate benefit agent selected from conditioning actives, scalp actives, encapsulated fragrance, emulsified fragrance, and mixtures thereof; (iv) 0.

Abstract: A method for controlling a braking system of an electromagnetic motor, the electromagnetic motor having a moveable output shaft, comprising the steps of: receiving a velocity signal and/or an acceleration signal based on movement of the output shaft, said velocity signal and/or acceleration signal having a respective frequency spectrum; identifying an event from the velocity and/or the acceleration signal using the respective frequency spectrum, wherein said event corresponds to an uncontrolled movement of the output shaft and has a characteristic frequency spectrum.

Abstract: A hair treatment composition comprising: a) a conditioning base comprising: i) a cationic conditioning surfactant having from 16 to 32 carbon atoms; ii) a fatty alcohol having from 8 to 22 carbon atoms; and b) from 0.1 to 10 wt % of a microcapsule in which a core comprising benefit agent is encapsulated in a polymeric shell; and (c) from 0.1 to 5 wt % of a diesterquat, provides improved deposition of microcapsules and delivery of benefit agent to hair surfaces.

Abstract: A composition comprising: (i) 0.01 to 10 wt % of a linear, cationic conditioning surfactant; (ii) 0.1 to 10 wt % of a linear fatty material; (iii) a particulate benefit agent selected from conditioning actives, scalp actives, encapsulated fragrance, emulsified fragrance, and mixtures thereof; (iv) 0.