Abstract: According to the invention there is a method of applying a catalyst layer to a surface, the method comprising the steps of: providing a donor substrate having opposing first and second surfaces and providing a catalyst ink disposed as a layer on the second surface, wherein the catalyst ink comprises a catalyst and a solvent; providing an acceptor substrate, wherein the second surface of the donor substrate faces towards the acceptor substrate; and irradiating the catalyst ink with laser radiation at a wavelength which is absorbed by the catalyst ink so as to transfer the catalyst ink from the donor substrate to the acceptor substrate.

Abstract: The following disclosure relates to electrolysis systems having an electrolysis cell stack and a fluids processing system (e.g., an oxygen and water gas separator). In certain examples, a portion of the fluids processing system is configured to operate at a reduced (lower) pressure than the electrolysis cell stack within the electrochemical processing system through the use of a recovery turbine positioned between the electrolysis cell stack and the oxygen and water gas separator along a fluids transfer line, wherein the recovery turbine is configured to reduce a pressure within the fluids transfer line from an elevated pressure at the electrolysis cell stack to the lower pressure at the separator.

Abstract: A low floor electric bus includes a frame extending longitudinally from a front end to a rear end, the frame having two sidepieces and a plurality of crossmembers extending between and coupled to the sidepieces, wherein the frame has a central section positioned at a lower height relative to the front and/or rear sections. The bus further includes a battery pack mounted to the central section of the frame; a powertrain having an electric motor and a driveshaft, wherein the electric motor is mounted to the rear section of the frame behind a rear axle coupled to the frame and the driveshaft extends from the electric motor to the rear axle; and a cradle coupled to the front section of the frame. A mixed-material cabin is also provided. The cabin includes a passenger cabin with a floor, sidewalls, and ceiling having steel, ceramic, and composite components.

Abstract: Blended polymers that exhibit both conductive and adhesive properties are provided. OTFTs comprising such polymers are also provided, as are methods of manufacturing the same.

Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a Raf family kinase inhibitor and a KRAS G12C inhibitor of Formula (I), Formula I-A or Formula I-B, pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.

Abstract: Implementations describe systems and methods for manufacturing and performing quality assessment of dental appliances. In one embodiment, a method of manufacturing a dental appliance comprises receiving, at a holder, a feature of the dental appliance, the feature comprising a first surface having a first shape, wherein the holder holds the feature of the dental appliance at a reference position. The method further includes automatically placing an object against the feature at the reference position using a robot arm, wherein the object comprises a second surface having a second shape that mates with the first shape. The method further includes applying pressure to press the object against the feature of the dental appliance and bonding the object to the feature of the dental appliance while applying the pressure.

Abstract: An embodiment of an exhaust collection system for collecting exhaust from a marine vessel includes an exhaust cleaning assembly including a tank. In addition, the exhaust collection system includes a vent hood in fluid communication with the tank of the exhaust cleaning assembly. The vent hood includes a frame including one or more extendable frame members, and an outer covering that covers the frame to define an enclosure with an opening configured to receive an exhaust stack of the marine vessel therethrough, the one or more extendable frame members to extend and retract to adjust a size of the opening.

Abstract: Tagging a corpus of tests based upon failure analysis. Access tags associated with test cases known to execute without error against an original corpus of source code. Access a test set associated with the accessed tags, the test set containing test cases. Access a new corpus of source code to be tested. Execute the new corpus of source code using test cases from the accessed test set. Access errors generated by execution of the new corpus of source code using the test cases. Determine locations in the new corpus of source code associated with the accessed errors. Execute natural language processing software to generate new tags associated with the locations in the new corpus of source code associated with the accessed errors.

Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: A message management platform may receive, from an application operator, a configuration of a message flow. The message flow includes one or more messages associated with trigger conditions. The platform may receive, from a code snippet incorporated in an application of a user computing device, a notification that the user computing device has used the application. The platform may associate a user identifier with the user computing device. The platform may subscribe to, on behalf of the application operator, one or more API notification channels of the application builder platform. The platform may receive an API notification from the application builder platform. The platform may determine that the application builder platform's user is associated with the user identifier used by the message management platform. The platform may determine that the event described in the payload matches the trigger condition and transmit the first message to the user computing device.

Abstract: Systems, media, and methods for automated response to social queries comprising: monitoring queries from users, each query submitted to a vendor via an interactive chat feature of an external electronic communication platform, monitoring human responses to the queries, monitoring subsequent communications conducted via the electronic communication platform until each query is resolved; applying a first machine learning algorithm to the monitored communications to identify a query susceptible to response automation; applying a second machine learning algorithm to the query susceptible to response automation to identify one or more responses likely to resolve the query; and either i) notifying a human to respond to the query susceptible to response automation with the one or more responses likely to resolve the query, or ii) instantiating an autonomous software agent configured to respond to the query susceptible to response automation with the one or more responses likely to resolve the query.

Abstract: A vehicle storage system may include a deck configured to span substantially a total width of a vehicle bed, four support feet including two front support feet and two rear support feet, a single drawer, and a storage compartment situated between the drawer and a side of the vehicle bed. The deck may include raised portions for coupling to an underside of an accessory case, and tie down attachment points that anchor materials to the deck, while transferring load and connecting the storage system to the truck bed. The drawer assembly may extend outward from the deck to allow full opening of the accessory case without removal of the accessory case from the drawer assembly.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: This disclosure relates to methods of treating cancer. This disclosure further relates to treating cancer in a subject with compounds that are inhibitors of PRMT5, particularly in combination with CDK4/6 inhibitors.

Abstract: Methods of forming an optical fiber assembly involve placing an adhesive in a ferrule assembly, heating the ferrule assembly through thermal induction, inserting an optical fiber into the ferrule bore during or after the heating step, and securing the optical fiber to the ferrule assembly using the adhesive. The thermal induction causes the adhesive to efficiently take or maintain a melted form to allow the optical fiber insertion.

Abstract: A side view mirror assembly includes a base frame configured to couple to a bracket that is connected to a vehicle static structure. The base frame interfacing with the bracket through a guide that is at least partially received within a pocket when the base frame is coupled to the bracket. A mirror housing assembly is adjustably supported by the base frame.

Abstract: There is provided a seal assembly comprising: a first component and a second component spaced apart from the first component so as to define a passage for the transfer of fluid from an inlet of the seal assembly to an outlet of the seal assembly, wherein the first component comprises a concavity at least partially defining the passage, and wherein no part of the second component extends into the portion of the passage bounded by the concavity.

Abstract: A magnetic and modular serving board is described. The magnetic and modular serving board includes a multitude of an individual sidewall, the sidewall having an inner surface and an outer surface. The individual sidewall is connected together to form a connected sidewall in a polygon shape. The inner perimeter of the connected sidewalls forms a recessed area. A magnet is attached to the outer surface of each individual sidewall. The magnet is arranged along the outer perimeter of the connected sidewalls such that a polarity of one magnet is different from the polarity of the attached magnet of the immediate adjacent sidewall. The magnetic and modular serving board also includes a base extending from a bottom surface. The base matches the polygon shape of the connected walls and sits within the recessed area and inner perimeter of another magnetic and modular serving board.

Abstract: A safety system for a storage tank. The storage tank includes a storage chamber configured to store a working fluid, a first skin forming the storage chamber, a second skin positioned radially outwardly of the first skin, an insulation cavity formed between the first skin and the second skin and a pressure sensor configured to measure a pressure in the insulation cavity. The safety system is configured to monitor a rate of change in the measured pressure and to determine that damage to the storage tank has occurred if the rate of change in the measured pressure is above a desired value.

Abstract: A storage tank includes a storage chamber configured to store a working fluid, a first skin forming the storage chamber, a second skin positioned radially outwardly of the first skin, an insulation cavity formed between the first skin and the second skin, and a foam layer positioned radially outwardly of the second skin. The foam layer may comprise a low density polyurethane foam, or a mid-high density polyurethane foam.