Abstract: A stimulation system for a patient is provided. The system comprises: at least one implantable device comprising at least one implantable antenna; and an external device comprising at least one external antenna, wherein the at least one external antenna transfers power to the at least one implantable antenna. The at least one implantable device delivers therapy to the patient. A patient attachment device or body covering positions the at least one external antenna relative to the patient.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a homologous prime/boost vaccination strategy, such as adenoviral vectors for use in a homologous prime/boost vaccination strategy.

Abstract: An encoder operable to filter audio signals into a plurality of frequency band components, generate quantized digital components for each band, identify a potential for pre-echo events within the generated quantized digital components, generate an approximate signal by decoding the quantized digital components using inverse pulse code modulation, generate an error signal by comparing the approximate signal with the sampled audio signal, and process the error signal and quantized digital components. The encoder operable to process the error signal by processing delayed audio signals and Q band values, determining the potential for pre-echo events from the Q band values, and determining scale factors and MDCT block sizes for the potential for pre-echo events.

Abstract: The present disclosure describes a system and methods for positioning a configured number of biomaterials on a surface. The method disclosed includes the formation of a membrane mask structure including a configured number of nanopores. The nanopores are generally sized to be the same size as, or slightly larger than a single target biomaterial. The masking membrane is then adhered to a substrate. The substrate may include a raw substrate, or may be functionalized for the purpose of binding biomaterials with greater attraction. A solution including the target biomaterials is then exposed to the masking membrane. One biomaterial is able to adhere to the substrate through each nanopore. The solution is rinsed from the membrane surface leaving only the biomaterial that has adhered to the substrate with a relatively strong binding force. The masking membrane may then either remain or may be removed.

Abstract: A drilling machine for angled drilling has a platform having a longitudinal axis and a transverse axis. The drilling machine includes a tower for holding a drill string and a tower interface assembly connected to the platform, so that the tower interface assembly moveably supports the tower. The tower interface assembly is selectively moveable to tilt the tower in either a plane parallel with the longitudinal axis of the platform, or to tilt the tower in a plane parallel with the transverse axis of the platform, so that the tilted drill string can perform angled drilling in either position. Further, the tower interface assembly is selectively moveable to simultaneously tilt the tower in the plane parallel with the longitudinal axis of the platform, and the plane parallel with the transverse axis of the platform.

Abstract: Systems, media, and methods for automated response to social queries comprising: monitoring queries from users, each query submitted to a vendor via an interactive chat feature of an external electronic communication platform, monitoring human responses to the queries, monitoring subsequent communications conducted via the electronic communication platform until each query is resolved; applying a first machine learning algorithm to the monitored communications to identify a query susceptible to response automation; applying a second machine learning algorithm to the query susceptible to response automation to identify one or more responses likely to resolve the query; and either i) notifying a human to respond to the query susceptible to response automation with the one or more responses likely to resolve the query, or ii) instantiating an autonomous software agent configured to respond to the query susceptible to response automation with the one or more responses likely to resolve the query.

Abstract: Accelerators, methods of manufacturing accelerators, and gas turbine engines are provided. For example, an accelerator for a gas turbine engine defines a radial direction and an axial direction and comprises an annular outer wall, an annular inner wall, an annular channel defined between the outer and inner walls, and a plurality of vanes disposed within the channel. The channel has an inlet for ingress of a cooling fluid and an outlet for egress of the cooling fluid. Each vane extends from the outer wall to the inner wall adjacent the outlet, which is angled such that an exit angle of the cooling fluid is nonzero with respect to both the radial and axial directions. The accelerator may be manufactured using an additive manufacturing method. The accelerator outlet may be disposed immediately upstream of a first turbine rotor blade stage of a gas turbine engine to direct the cooling fluid thereto.

Abstract: The disclosure relates to the system comprising a combination of a primary bioreactor with a secondary bioreactor to convert a gaseous stream comprising CO and optionally H2, or CO2 and H2 to at least one target product. Bioreactors may be any combination of aerobic and anaerobic, batch and continuous. The bioreactors comprise fermenting microorganisms that may typically be bacterial or fungal.

Abstract: Systems, methods, and computer readable media for decentralized two-phase commit in a datastore or database where the methods include determining pre-validating a transaction, writing first metadata to a leader partition, the first metadata including a state indicating preparing and mutations of the transaction, and writing second metadata of a follower partition to indicate the follower partition is locked by the leader partition. The methods further include updating the state of the first metadata to indicate committed and performing the transaction on the leader partition, performing the transaction on the follower partition and unlocking the follower partition, and updating the first metadata to remove the mutations of the transaction and updating the state of the first metadata to indicate the transaction is completed. The methods may further include selecting a leader partition key and updating the state of the first metadata to indicate committed unapplied.

Abstract: A side view mirror assembly includes a base frame configured to couple to a bracket that is connected to a vehicle static structure. The base frame interfacing with the bracket through a guide that is at least partially received within a pocket when the base frame is coupled to the bracket. A mirror housing assembly is adjustably supported by the base frame.

Abstract: A method of transferring at least one subterranean core sample from a retrieval vessel to a testing vessel can include removing at least one pressure barrier on the retrieval vessel using a linear actuator while maintaining a sampling pressure on the at least one subterranean core sample at which the at least one subterranean core sample is taken from a subterranean formation. The method can also include pressurizing the testing vessel to the sampling pressure using the linear actuator, and transferring the at least one subterranean core sample from the retrieval vessel to the testing vessel. The method can further include sealing the testing vessel with the at least one subterranean core sample at the sampling pressure, where the testing vessel allows the at least one subterranean core sample to be tested while the at least one subterranean core sample is maintained at the sampling pressure.

Abstract: A mask-based diagnostic device, includes a face mask, where an inside of the face mask defines during use a confined local environment that includes breath vapor exhaled from the lungs of a user. An exhaled breath condensate (EBC) collector has a condensate forming surface for converting exhaled breath vapor into an EBC liquid sample. The EBC collector includes a thermal mass cooled before use to a condensation forming temperature less than a confined environment temperature of the confined environment inside of the face mask, and an EBC testing unit for testing the EBC sample for a target molecule, where the EBC sample contains water and the target molecule, the EBC testing unit includes a printed circuit board supporting a semiconductor packaged electronic biosensor in electrical communication with power, analysis and communications electronics, a fluid conductor for conducting the EBC sample to the electronic biosensor.

Abstract: The disclosure relates to the combination of a primary fermentation that converts gas to acetate with a secondary fermentation that converts acetate to a target product. Preferably, the gas contains carbon dioxide, such that the disclosure enables the fixation of carbon dioxide into useful products. The fermentations may be any combination of aerobic and anaerobic, batch and continuous. The fermenting microorganisms may typically be bacterial or fungal.

Abstract: A decentralized two-phase commit in a datastore or database includes determining pre-validating a transaction, writing first metadata to a leader partition, the first metadata including a state indicating preparing and mutations of the transaction, and writing second metadata of a follower partition to indicate the follower partition is locked by the leader partition. The decentralized two-phase commit further includes updating the state of the first metadata to indicate committed and performing the transaction on the leader partition, performing the transaction on the follower partition and unlocking the follower partition, and updating the first metadata to remove the mutations of the transaction and updating the state of the first metadata to indicate the transaction is completed. The decentralized two-phase commit may further include selecting a leader partition key and updating the state of the first metadata to indicate committed unapplied.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for a lighting controller for sea lice detection. In some implementations, fish are contained within an elliptical tank filled with water. An imaging station located on the elliptical tank is used to capture an image of a fish from which image analysis can be performed to detect sea lice or other skin features, including lesions, on the fish. Pairs of imaging assemblies coordinate pulsing light of at least a first and a second color and capturing images of the fish while the fish is illuminated by at least the first and the second color. By using the captured images with different color light, computers can detect features on the body of a fish including sea lice, skin lesions, shortened operculum or other physical deformities and skin features. Detection results can aid in mitigation techniques or be stored for analytics.

Abstract: A system for transferring at least one subterranean core sample under pressure can include a retrieval vessel that collects and houses the at least one subterranean core sample at a sampling pressure at which the at least one subterranean core is collected. The system can also include a linear actuator that couples to the retrieval vessel through a valve in the open position at a first time, where the linear actuator facilitates removal of at least one pressure barrier from the retrieval vessel through the valve at the first time while maintaining the sampling pressure of the at least one subterranean sample. The system can further include a testing vessel that couples to the linear actuator through the valve in the open position at a second time, and a hydraulic device that facilitates pressurizing the testing vessel to the sampling pressure at the second time.

Abstract: A system for investigative analysis.

Abstract: A side view mirror assembly includes a base frame configured to couple to a bracket that is connected to a vehicle static structure. The base frame interfacing with the bracket through a guide that is at least partially received within a pocket when the base frame is coupled to the bracket. A mirror housing assembly is adjustably supported by the base frame.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.