Patents by Inventor James A. DiCarlo
James A. DiCarlo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240082534Abstract: Techniques for non-invasively controlling targeted neural activity of a subject are provided herein. The techniques include applying a stimulus input to the subject, the stimulus input being formed by a deep artificial neural network (ANN) model and being configured to elicit targeted neural activity within a brain of the subject. The stimulus input may be a pattern of luminous power generated by the deep ANN model and applied to retinae of the subject. The stimulus input may be generated by the deep ANN model based on a mapping of the subject's neural responses to neurons of the deep ANN model.Type: ApplicationFiled: October 6, 2023Publication date: March 14, 2024Applicant: Massachusetts Institute of TechnologyInventors: James DICARLO, Pouya BASHIVAN, Kohitij KAR
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Patent number: 11813406Abstract: Techniques for non-invasively controlling targeted neural activity of a subject are provided herein. The techniques include applying a stimulus input to the subject, the stimulus input being formed by a deep artificial neural network (ANN) model and being configured to elicit targeted neural activity within a brain of the subject. The stimulus input may be a pattern of luminous power generated by the deep ANN model and applied to retinae of the subject. The stimulus input may be generated by the deep ANN model based on a mapping of the subject's neural responses to neurons of the deep ANN model.Type: GrantFiled: April 30, 2020Date of Patent: November 14, 2023Assignee: Massachusetts Institute of TechnologyInventors: James Dicarlo, Pouya Bashivan, Kohitij Kar
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Publication number: 20220380811Abstract: Methods of multiplex genome engineering in cells using Cas9 is provided which includes a cycle of steps of introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to the target DNA and which guide the enzyme to the target DNA, wherein the one or more RNAs and the enzyme are members of a co-localization complex for the target DNA, and introducing into the cell a second foreign nucleic acid encoding one or more donor nucleic acid sequences, and wherein the cycle is repeated a desired number of times to multiplex DNA engineering in cells.Type: ApplicationFiled: June 10, 2022Publication date: December 1, 2022Inventors: George M. Church, James Dicarlo
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Patent number: 11459585Abstract: Methods of multiplex genome engineering in cells using Cas9 is provided which includes a cycle of steps of introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to the target DNA and which guide the enzyme to the target DNA, wherein the one or more RNAs and the enzyme are members of a co-localization complex for the target DNA, and introducing into the cell a second foreign nucleic acid encoding one or more donor nucleic acid sequences, and wherein the cycle is repeated a desired number of times to multiplex DNA engineering in cells.Type: GrantFiled: July 8, 2014Date of Patent: October 4, 2022Assignee: President and Fellows of Harvard CollegeInventors: George M. Church, James Dicarlo
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Publication number: 20200345968Abstract: Techniques for non-invasively controlling targeted neural activity of a subject are provided herein. The techniques include applying a stimulus input to the subject, the stimulus input being formed by a deep artificial neural network (ANN) model and being configured to elicit targeted neural activity within a brain of the subject. The stimulus input may be a pattern of luminous power generated by the deep ANN model and applied to retinae of the subject. The stimulus input may be generated by the deep ANN model based on a mapping of the subject's neural responses to neurons of the deep ANN model.Type: ApplicationFiled: April 30, 2020Publication date: November 5, 2020Applicant: Massachusetts Institute of TechnologyInventors: James Dicarlo, Pouya Bashivan, Kohitij Kar
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Publication number: 20160168592Abstract: Methods of multiplex genome engineering in cells using Cas9 is provided which includes a cycle of steps of introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to the target DNA and which guide the enzyme to the target DNA, wherein the one or more RNAs and the enzyme are members of a co-localization complex for the target DNA, and introducing into the cell a second foreign nucleic acid encoding one or more donor nucleic acid sequences, and wherein the cycle is repeated a desired number of times to multiplex DNA engineering in cells.Type: ApplicationFiled: July 8, 2014Publication date: June 16, 2016Inventors: George M. Church, James Dicarlo
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Patent number: 8894918Abstract: Methods are disclosed for producing architectural preforms and high-temperature composite structures containing high-strength ceramic fibers with reduced preforming stresses within each fiber, with an in-situ grown coating on each fiber surface, with reduced boron within the bulk of each fiber, and with improved tensile creep and rupture resistance properties tier each fiber. The methods include the steps of preparing an original sample of a preform formed from a pre-selected high-strength silicon carbide ceramic fiber type, placing the original sample in a processing furnace under a pre-selected preforming stress state and thermally treating the sample in the processing furnace at a pre-selected processing temperature and hold time in a processing gas having a pre-selected composition, pressure, and flow rate.Type: GrantFiled: February 19, 2010Date of Patent: November 25, 2014Assignee: The United States of America as Represented by the Administrator of National Aeronautics and Space AdministrationInventors: James A. DiCarlo, Hee-Mann Yun
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Publication number: 20120076927Abstract: A thermal treatment process for improving thermo-mechanical properties of ceramic matrix composite materials such as silicon carbide (SiC) matrix composites is described. The treatment process removes excess silicon and/or other process-related defects from the SiC-based matrix as well as the fiber interfacial coating. This invention can be practiced with minimal strength loss for as-fabricated composites formed from high-strength continuous-length ceramic and carbon-based fibers that are functionally stable to 1600° C. and above. The invention provides a method for significantly improving composite thermal conductivity and creep resistance, and for reducing composite porosity.Type: ApplicationFiled: February 1, 2011Publication date: March 29, 2012Applicant: UNITED STATES GOVERNMENT AS REPRESENTED BY THE SECRETARY OF THE ARMYInventors: Ramakrishna T. Bhatt, James A. Dicarlo
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Publication number: 20100289192Abstract: Methods are disclosed for producing architectural preforms and high-temperature composite structures containing high-strength ceramic fibers with reduced preforming stresses within each fiber, with an in-situ grown coating on each fiber surface, with reduced boron within the bulk of each fiber, and with improved tensile creep and rupture resistance properties tier each fiber. The methods include the steps of preparing an original sample of a preform formed from a pre-selected high-strength silicon carbide ceramic fiber type, placing the original sample in a processing furnace under a pre-selected preforming stress state and thermally treating the sample in the processing furnace at a pre-selected processing temperature and hold time in a processing gas having a pre-selected composition, pressure, and flow rate.Type: ApplicationFiled: February 19, 2010Publication date: November 18, 2010Inventors: James A. DiCarlo, Hee-Mann Yun
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Patent number: 7687016Abstract: Methods are disclosed for producing architectural preforms and high-temperature composite structures containing high-strength ceramic fibers with reduced preforming stresses within each fiber, with an in-situ grown coating on each fiber surface, with reduced boron within the bulk of each fiber, and with improved tensile creep and rupture resistance properties for each fiber. The methods include the steps of preparing an original sample of a preform formed from a pre-selected high-strength silicon carbide ceramic fiber type, placing the original sample in a processing furnace under a pre-selected preforming stress state and thermally treating the sample in the processing furnace at a pre-selected processing temperature and hold time in a processing gas having a pre-selected composition, pressure, and flow rate.Type: GrantFiled: February 13, 2004Date of Patent: March 30, 2010Assignee: The United States of America as represented by the Administrator of National Aeronautics and Space AdministrationInventors: James A. DiCarlo, Hee Yun
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Patent number: 7427428Abstract: A ceramic matrix composite material is disclosed having non-oxide ceramic fibers, which are formed in a complex fiber architecture by conventional textile processes; a thin mechanically weak interphase material, which is coated on the fibers; and a non-oxide or oxide ceramic matrix, which is formed within the interstices of the interphase-coated fiber architecture. During composite fabrication or post treatment, the interphase is allowed to debond from the matrix while still adhering to the fibers, thereby providing enhanced oxidative durability and damage tolerance to the fibers and the composite material.Type: GrantFiled: June 24, 2003Date of Patent: September 23, 2008Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: James A. DiCarlo, Ramakrishna Bhatt, Gregory N. Morscher, Hee-Mann Yun
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Publication number: 20070121065Abstract: Eye-tracking devices and method of operation may utilize a magnetic article associated with an eye and a sensing device to detect a magnetic field generated by the magnetic article.Type: ApplicationFiled: March 23, 2006Publication date: May 31, 2007Inventors: David Cox, James DiCarlo
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Patent number: 6513962Abstract: An illumination system for illuminating an area within a room includes one or more light sources, preferably disposed outside the room, one or more lighting heads disposed within the room, one or more light pipes and/or fiber bundles to transmit light from the source(s) to the lighting head(s). The system includes means for controlling both the intensity and the color rendering index of the light emitted from the lighting head. In a preferred embodiment, the sources include an incandescent source extending across the visible spectrum and a light emitting diode source which emits essentially red light, and control of the color rendering index is effected by controlling the relative amounts of light from the two sources reaching the lighting head. Preferred forms of the invention also include special joints which permit all necessary translations and rotations of the lighting head while still permitting a continuous light path via fiber bundles and/or light pipes from the source to the lighting head.Type: GrantFiled: December 14, 1999Date of Patent: February 4, 2003Assignee: Getinge/Castle, Inc.Inventors: Alvin C. Mayshack, Thomas J. Brukilacchio, Lynn W. Noble, Arkady Pievsky, Benoit Boulant, Paul B. Elterman, Brain James DiCarlo