Abstract: The present disclosure relates to compounds, compositions, and methods for the inducing neurodegenerative disease pathologies. In one aspect, disclosed herein is a nucleotide sequence encoding a chimeric polypeptide, comprising: a first nucleotide sequence encoding a light-induced oligomerization domain and a second nucleotide sequence encoding a neurodegenerative disease in target protein. Disclosed herein is a method of inducing a neurodegenerative disease pathology in a cell, comprising the steps: introducing into the cell an expression vector encoding a chimeric polypeptide, comprising: a first nucleotide sequence encoding a light-induced oligomerization domain and a second nucleotide sequence encoding a low complexity domain from a neurodegenerative disease target protein, wherein the first nucleotide sequence is operably linked to a promoter; expressing the chimeric polypeptide; and inducing oligomerization of the chimeric polypeptide by stimulation with blue light.

Abstract: A heat store (10) for an energy storage system includes a solid body (20) comprising a solid thermally conductive matrix (22) with a solid thermal filler material (21) embedded therein. The solid thermally conductive matrix (22) forms a thermally conductive pathway to the solid thermal filler material (21) distributed within the solid thermally conductive matrix (22). The heat store (10) for the energy storage system also includes a thermal transfer element (30).

Abstract: The present invention relates to a clinical dispenser and applicator and, more particularly, to a clinical dispenser and applicator that is structured to hold and dispense a micro amount (one to several drops) of liquids/solvents in a clinical setting.

Abstract: The present disclosure relates to compounds, compositions, and methods for the inducing neurodegenerative disease pathologies. In one aspect, disclosed herein is a nucleotide sequence encoding a chimeric polypeptide, comprising: a first nucleotide sequence encoding a light-induced oligomerization domain and a second nucleotide sequence encoding a neurodegenerative disease in target protein. Disclosed herein is a method of inducing a neurodegenerative disease pathology in a cell, comprising the steps: introducing into the cell an expression vector encoding a chimeric polypeptide, comprising: a first nucleotide sequence encoding a light-induced oligomerization domain and a second nucleotide sequence encoding a low complexity domain from a neurodegenerative disease target protein, wherein the first nucleotide sequence is operably linked to a promoter; expressing the chimeric polypeptide; and inducing oligomerization of the chimeric polypeptide by stimulation with blue light.

Abstract: Methods are disclosed for analysing genetic data about an organism. In one arrangement, input units are derived from studies that provide information about the association between genetic variants and phenotypes. Input units are assigned to one of a plurality of clusters, based on an assessment of the extent to which input units share genetic variants that affect any aspect of the phenotype corresponding to each input unit or any of the underlying biological mechanisms of the phenotype, thereby identifying phenotypes that share underlying biological mechanisms.

Abstract: The present disclosure relates to compounds, compositions, and methods for the induction of membraneless organelles.

Abstract: A heatshield for a band clamp, the heatshield having: an attachment member configured to be inserted axially into the clamp; and a thermal insulator secured to the attachment member, the thermal insulator being configured to at least partially extend over an outer surface of the clamp when the attachment member is inserted into the clamp.

Abstract: An exhaust silencer for a motor vehicle is provided. In one example, the silencer comprises a noise-reducing structure and a heat sink to transfer heat from exhaust gases to the exterior of the silencer, the heat sink comprising two regions of fins which define a plurality of flow channels through the heat sink, the flow channels directing the flow of exhaust through the silencer from an inlet passage to an outlet passage. In this way, a temperature of the exhaust is reduced, and the silencer and downstream components of an exhaust system may be constructed of materials of a lower thermal tolerance.

Abstract: A heatshield for a band clamp, the heatshield comprising: an attachment member configured to be inserted axially into the clamp; and a thermal insulator secured to the attachment member, the thermal insulator being configured to at least partially extend over an outer surface of the clamp when the attachment member is inserted into the clamp.

Abstract: A dental blank holder for the manufacture of dental articles. The dental blank holder can include a frame configured to cooperate with a blank holder of a dental mill. The frame can includes an inner periphery and an outer periphery, the inner periphery including a plurality of receiving walls forming receiving spaces, each receiving space configured to receive a dental blank. The dental blank holder may also include a movable arm configured to form a plurality of locking walls, each locking wall configured to enclose a corresponding receiving space, the movable arm including at least one biasing member configured to apply an individual force toward each receiving space such that each of the dental blanks is held in the receiving spaces for a milling process.

Abstract: A method, system and computer program product are provided for implementing concurrent adapter firmware update of a Single Root Input/Output Virtualization (SRIOV) adapter in a virtualized system. An adapter driver is used to update adapter firmware concurrent with normal I/O operations. When configuration is stored in a scratchpad buffer, the adapter driver detects virtual functions (VFs) configured and operating. An enhanced error handling (EEH) process is initiated, freezing the VFs, and an updated adapter firmware image is loaded to the adapter. The adapter driver completes the EEH recovery, the adapter is restarted using the new updated adapter firmware. The VFs device drivers unfreeze the VFs, and complete the EEH recovery.

Abstract: A method, system and computer program product are provided for implementing concurrent adapter firmware update of a Single Root Input/Output Virtualization (SRIOV) adapter in a virtualized system. An adapter driver is used to update adapter firmware concurrent with normal I/O operations. When configuration is stored in a scratchpad buffer, the adapter driver detects virtual functions (VFs) configured and operating. An enhanced error handling (EEH) process is initiated, freezing the VFs, and an updated adapter firmware image is loaded to the adapter. The adapter driver completes the EEH recovery, the adapter is restarted using the new updated adapter firmware. The VFs device drivers unfreeze the VFs, and complete the EEH recovery.

Abstract: The present invention relates to a clinical dispenser and applicator and, more particularly, to a clinical dispenser and applicator that is structured to hold and dispense a micro amount (one to several drops) of liquids/solvents in a clinical setting.

Abstract: An exhaust silencer for a motor vehicle is provided. In one example, the silencer comprises a noise-reducing structure and a heat sink to transfer heat from exhaust gases to the exterior of the silencer, the heat sink comprising two regions of fins which define a plurality of flow channels through the heat sink, the flow channels directing the flow of exhaust through the silencer from an inlet passage to an outlet passage. In this way, a temperature of the exhaust is reduced, and the silencer and downstream components of an exhaust system may be constructed of materials of a lower thermal tolerance.

Abstract: A dental blank holder for the manufacture of dental articles. The dental blank holder can include a frame configured to cooperate with a blank holder of a dental mill. The frame can includes an inner periphery and an outer periphery, the inner periphery including a plurality of receiving walls forming receiving spaces, each receiving space configured to receive a dental blank. The dental blank holder may also include a movable arm configured to form a plurality of locking walls, each locking wall configured to enclose a corresponding receiving space, the movable arm including at least one biasing member configured to apply an individual force toward each receiving space such that each of the dental blanks is held in the receiving spaces for a milling process.

Abstract: A method, system and computer program product are provided for implementing concurrent adapter firmware update of a Single Root Input/Output Virtualization (SRIOV) adapter in a virtualized system. An adapter driver is used to update adapter firmware concurrent with normal I/O operations. When configuration is stored in a scratchpad buffer, the adapter driver detects virtual functions (VFs) configured and operating. An enhanced error handling (EEH) process is initiated, freezing the VFs, and an updated adapter firmware image is loaded to the adapter. The adapter driver completes the EEH recovery, the adapter is restarted using the new updated adapter firmware. The VFs device drivers unfreeze the VFs, and complete the EEH recovery.

Abstract: A helically formed flexible duct primarily directed to applications in ducted heating, ventilating and air conditioning, of three dimensions including a predetermined length, an inner diameter reinforced with a helically laminated wire member between self laminating substrate, an outwardly radial compartment formation constructed with strip portions of substrate material which form gaps to accommodate outwardly expanding radial dimensions and containing an insulating member, and an outer covering member delivered to a larger radial circumference at an applied circumferential speed exceeding the circumferential speed of the inner diameter substrate tube formation rate.

Abstract: A method, system and computer program product are provided for implementing concurrent adapter firmware update of a Single Root Input/Output Virtualization (SRIOV) adapter in a virtualized system. An adapter driver is used to update adapter firmware concurrent with normal I/O operations. When configuration is stored in a scratchpad buffer, the adapter driver detects virtual functions (VFs) configured and operating. An enhanced error handling (EEH) process is initiated, freezing the VFs, and an updated adapter firmware image is loaded to the adapter. The adapter driver completes the EEH recovery, the adapter is restarted using the new updated adapter firmware. The VFs device drivers unfreeze the VFs, and complete the EEH recovery.

Abstract: A method of determining an allelic type of a specific individual, comprising: accessing a database of genetic information on a plurality of individuals, the genetic information comprising: the allelic type of each individual; and the type of each of a plurality of genetic markers for each individual; categorizing the data in the database into a plurality of groups of individuals, such that all individuals having the same allelic type are in the same group, and each group represents a different allelic type; inputting data comprising the type of each of a plurality of genetic markers of the specific individual having an unknown allelic type; specifying a set of genetic markers for which type information is known both for the individuals in the database and for the specific individual; applying a population genetic model to calculate the likelihood of sampling, from some or all of the groups in turn, the input type data of the specified set of genetic markers for the specific individual; and determining the

Abstract: A helically formed flexible duct primarily directed to applications in ducted heating, ventilating and air conditioning, of three dimensions including a predetermined length, an inner diameter reinforced with a helically laminated wire member between self laminating substrate, an outwardly radial compartment formation constructed with strip portions of substrate material which form gaps to accommodate outwardly expanding radial dimensions and containing an insulating member, and an outer covering member delivered to a larger radial circumference at an applied circumferential speed exceeding the circumferential speed of the inner diameter substrate tube formation rate.