Abstract: Provided herein are drug administration devices, methods, and systems for adjusting drug delivery to a patient to allow drug dosage to be adjusted based on a variety of different factors influencing the patient during administration of the drug. In one embodiment, a drug administration device or system can have a drug holder with a drug therein to be delivered to a patient, one or more sensors that are configured to gather various data associated with the patient, and at least one processor that can analyze the data gathered by the one or more sensors and adjust delivery of the drug based on the data.

Abstract: The deflectable tip catheters can be used with a primary delivery system (e.g., a bronchoscope, endoscope, or other surgical access device) to access a certain target tissue, such as a tumor (e.g., a lung tumor). The primary access device provides initial access and the deflectable tip catheter can be passed through the primary access device to reach the target tissue which is not otherwise accessible by the primary access device. The deflectable tip catheters have an internal bore free of obstructions such that a drug delivery device (e.g., a needle) or a diagnostic tool can be passed therethrough to directly access the target tissue.

Abstract: Various exemplary methods and devices (10, 110, 210) for delivering liquid therapeutic agents in solid tumors are provided. In general, a delivery device configured to deliver a liquid therapeutic agent into a solid tumor or other soft tissue can be configured to compress tissue and seal any fluid gaps around the delivery device during the delivery of the liquid therapeutic agent. In an exemplary embodiment the delivery device includes three elongate tubular shafts (12, 14, 16, 112, 114, 116, 212, 214, 216) configured to move longitudinally relative to one another. The elongate tubular shafts are configured to cooperate with one another to deliver the liquid therapeutic agent through a passageway of the delivery device to the solid tumor or other soft tissue and seal any fluid gaps around the delivery device while the liquid therapeutic agent is delivered into the solid tumor or other soft tissue.

Abstract: In general, drug administration devices configured to communicate with networks and external devices are provided. In an exemplary embodiment, a drug administration device is configured to adjust an operational parameter of the drug administration device based on a data packet formed from drug administration data ancillary data received from networks and/or external devices. In another example embodiment, a drug administration device is configured to scan for and establish communications with at least one external device. In another example embodiment, a method includes assessing whether to update a control program on a drug administration device from a network or external device. In another example embodiment, a system includes a first drug administration device configured to communicate with a second drug administration device to optimize a drug treatment.

Abstract: The present invention is directed to an intraluminal guiding device having an expandable guiding member so as to facilitate and overcome the difficulties associated with obtaining contra-lateral leg access of a bifurcated stent or a bifurcated stent graft with a second guidewire and a method for treating abdominal aortic aneurysms with such a device. The guiding device comprises a pre-loaded second wire positioned within the contra-lateral leg which facilitates access to said leg in accordance with the present invention.

Abstract: The present invention is directed to an intraluminal guiding device having an expandable guiding member so as to facilitate and overcome the difficulties associated with obtaining contra-lateral leg access of a bifurcated stent or a bifurcated stent graft with a second guidewire and a method for treating abdominal aortic aneurysms with such a device. The guiding device comprises a pre-loaded second wire positioned within the contra-lateral leg which facilitates access to said leg in accordance with the present invention.

Abstract: The present invention is directed to an intraluminal guiding device having an expandable guiding member so as to facilitate and overcome the difficulties associated with obtaining contra-lateral leg access of a bifurcated stent or a bifurcated stent graft with a second guidewire and a method for treating abdominal aortic aneurysms with such a device. The guiding device comprises a pre-loaded second wire positioned within the contra-lateral leg which facilitates access to said leg in accordance with the present invention.

Abstract: The present invention is directed to an intraluminal guiding device having an expandable guiding member so as to facilitate and overcome the difficulties associated with obtaining contra-lateral leg access of a bifurcated stent or a bifurcated stent graft with a second guidewire and a method for treating abdominal aortic aneurysms with such a device. The guiding device comprises a pre-loaded second wire positioned within the contra-lateral leg which facilitates access to said leg in accordance with the present invention.

Abstract: A medical filter retrieval system for retrieval of a medial filter from placement inside a body passage of a patient has a medical filter with a ferromagnetic head at one end thereof and a retrieval catheter. Located coaxially within the retrieval catheter are an elongated central probe having a ferromagnetic end. The medical filter is retrieved from the body passage by bringing the magnetic end of the central probe into proximity of the filter head which attracts and aligns the probe end to the filter head and magnetically attaches the probe end and head. Optionally, a snare device can be coaxially located within the retrieval catheter to engage the filter after the probe has been aligned with the filter head.

Abstract: A medical filter intended for placement inside a tubular body passage such as a blood vessel of a patient, the medical filter having an end member at one end of the longitudinal axis of the filter. The end member supports a retrieval element and a plurality of struts defining a first filter cone proximate to the end member and a second filter cone distal from the end member.

Abstract: A medical filter for placement in a tubular body passage. The filter has a main structure with a plurality of arms extending radially outwardly from the main structure to stand off the main structure from the wall of the tubular body passage. The filter is removed by first rotating the filter about its longitudinal axis to remove the stand-off arms from any endothelium attachments.

Abstract: A medical filter intended for placement inside a tubular body passage such as a blood vessel of a patient, the medical filter having a plurality of truncated baskets positioned along a spine. Each of the baskets is rotated about the axis of the spine to be out of alignment with adjacent baskets and the spine carrying a retrieval element such as a hook.

Abstract: A retrievable medical filter which can be placed in a blood vessel or other body passage. The filter has improved structural features for enhancing its filter effectiveness and to facilitate its retrieval from the body passage. The filter has a longitudinal spine with struts extending from each longitudinal to form filter baskets. The ends of the spine to which the struts are attached may be rings with serpentine cuts in the rings to make them expandable. The struts can extend circumferentially as well as radially outwardly to provide a structure which can be radially compressed without bending the struts in a tight radius.

Abstract: A medical filter intended for placement inside a tubular body passage of a patient has a generally longitudinally extending central spine with a retrieval element at one end; and a plurality of filter sections attached to and spaced along the spine, each of the filter sections having a plurality of radial arms attached to the spine and extending radially outwardly with parallel end segments extending axially generally parallel to the longitudinal axis, each of the end segments ending in a tip which extends radially inwardly. Each filter section may also have a graft band attached to the parallel end segments of the radial arms.

Abstract: A medical filter intended for placement inside a tubular body passage of a patient has a filter frame with a cell growth inhibiting sheet attached to the struts of the frame to prevent or minimize growth of cells over the frame after it has been implanted in a vessel or body passage of a patient.

Abstract: A medical filter intended for placement inside a tubular body passage such as a blood vessel of a patient, the medical filter having a plurality of arms radiating from an elongated spine in a helical pattern.

Abstract: A stent includes a lattice of interconnecting elements defining a substantially cylindrical configuration having a first open end and a second open end. The lattice has a closed configuration and an open configuration. The lattice includes a plurality of adjacent hoops, wherein at least two hoops are movable to one or more discrete locked positions as the open configuration and at least one hoop interlocks with another hoop at the one or more discrete locked positions. Moreover, the stent can be made from a biodegradable or bioabsorbable material.

Abstract: A locking stent has a lattice of interconnecting elements defining a substantially cylindrical configuration having a first open end and a second open end. The lattice has a closed configuration and an open configuration. The lattice also has a plurality of adjacent hoops wherein each hoop is separated from another hoop in the closed configuration. Each hoop mateably connects with or interlocks with an adjacent hoop in the open configuration.