Abstract: The present invention relates to a method for the preparation of optionally substituted aryl and pyridyl pyrrolidines which are useful intermediates for the preparation of certain biologically active compounds.

Abstract: A series of thiazolo[5,4-d]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.

Abstract: The present application relates to a process based on the oxidative ring opening of a compound with oxindole structure for preparation of substituted 2-(triazinylcarbonyl)sulfonanilides of the formula (1-1) proceeding from N-sulfonyl-substituted 3-triazinyloxindole of the formula (2-1), and to the 2-(triazinylcarbonyl)sulfonanilides of the formula (1-1) thus prepared, and to the use thereof as intermediates for the synthesis of fine chemicals and of active ingredients in the agricultural sector. The invention also relates to a multistage process for preparation of N-alkyl-N-[2-(1,3,5-triazin-2-ylcarbonyl)phenyl]alkanesulfonamides of the formula (4-1), proceeding from a 3-(alkylsulfanyl)-1,3-dihydro-2H-indol-2-one of the formula (7-1), wherein the multistage process also comprises, as a component step, the oxidative ring opening mentioned, and to the 2-(triazinylcarbonyl)sulfonanilides of the formula (1-1) which are obtained by the oxidative ring opening and are used as intermediates in the multistage process.

Abstract: Continuous method for producing ortho-substituted anilines in a flow reactor Continuous process for preparing ortho-substituted anilines of the formula in a flow reactor in the presence of a nitrogen base not having an NH group, and multistage process for preparing herbicidal N-alkyl-N-[2-(1,3,5-triazin-2-ylcarbonyl)-phenyl]alkansulphonamides of the formula (4-1) wherein the continuous process for preparing ortho-substituted anilines of the formula (4) in a flow reactor constitutes the first process step of the multistage process for preparing the herbicidal active ingredients of the formula (4-1).

Abstract: The present invention relates to metal amides of the formula (I), to a process for preparation thereof and to the use thereof as bases for aromatics, heteroaromatics, alkenes, alkynes and other organic compounds having activated C—H bonds.

Abstract: A wheel assembly is provided with a frame adapted to be removably attached to a cooler. The wheel assembly includes a frame adapted to be removably attached to a cooler; a first wheel attached to a first end of the frame and a second wheel attached to a second end of the frame; and at least one protrusion extending from the frame, wherein the protrusion is adapted to be received by a void formed in a cooler such that the wheel assembly is moveable between a first position wherein the frame is attached to the cooler and a second position wherein the frame is unattached to the cooler.

Abstract: Process for the selective N-sulfonylation of oxindoles, in particular process for the N-sulfonylation of 3-triazinyloxindoles, and also N-sulfonyl-substituted 3-triazinyl-oxindoles and the use of N-sulfonyl-substituted oxindoles and of N-sulfonyl-substituted 3-triazinyloxindoles as intermediates for the synthesis of fine chemicals and of active ingredients in the field of pharmacy and agriculture, and also the use of these compounds as active ingredients in the field of agriculture.

Abstract: Disclosed are a series of quinoline and quinoxaline derivatives comprising a fluorinated ethyl side-chain, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: Process for the preparation of triazinyl-substituted oxindoles of formula (3) and salts thereof by reacting an oxindole (1) with a triazine (2) in the presence of a carbonate, a hydroxide, a phosphate or a mixture of two or more of the aforementioned compounds, and also the compounds of formula (3) and salts thereof (3?) and the use of both for producing crop protection agents.

Abstract: The locking V hinge tool of this invention comprises three or more pieces. The first two pieces are fundamentally identical and reversed, comprised of three main sections in optional order of, a jaw end, a common axle, and a arc-like cam, assembled together and rotate through the common axle, allowing the jaw ends to open and close. A third pin holding piece holds a pin that rides in and moves, the criss-crossing arc-like slots in the other pieces, at or near an angle aimed at the corners of a diamond like opening where the two arc-like slots intersect. Any external force exerted on the jaw ends, attempt to force the pin in the arc-like slots to rise to an upright position but are blocked by the walls.

Abstract: Process for the selective N-sulfonylation of oxindoles, in particular process for the N-sulfonylation of 3-triazinyloxindoles, and also N-sulfonyl-substituted 3-triazinyloxindoles and the use of N-sulfonyl-substituted oxindoles and of N-sulfonyl-substituted 3-triazinyloxindoles as intermediates for the synthesis of fine chemicals and of active ingredients in the field of pharmacy and agriculture, and also the use of these compounds as active ingredients in the field of agriculture.

Abstract: The present invention provides bicyclo[3.2.1]octyl amide derivatives of formula (I): wherein L, R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.

Abstract: Methods of treating a subject with cancer characterized by an impaired ability to repair oxidative DNA damage, comprising administering to the subject an effective amount of a bis(thiohydrazide amide) compound are provided.

Abstract: Process for the preparation of triazinyl-substituted oxindoles of formula (3) and salts thereof by reacting an oxindole (1) with a triazine (2) in the presence of a carbonate, a hydroxide, a phosphate or a mixture of two or more of the aforementioned compounds, and also the compounds of formula (3) and salts thereof (3?) and the use of both for producing crop protection agents.

Abstract: The present invention relates to a process for preparing dithiinetetracarboximides by reaction of succinic monoamides with thionyl chloride, with continuous performance of at least one of the process steps.

Abstract: The present invention relates to metal amides of the formula (I), to a process for preparation thereof and to the use thereof as bases for aromatics, heteroaromatics, alkenes, alkynes and other organic compounds having activated C—H bonds.

Abstract: The present application relates to a process for preparing chloroamines which can be used as precursors for syntheses of fine chemicals and active ingredients from pharmaceuticals and/or agriculture, by reaction of secondary amines of the formula (II) with chlorine gas in the presence of an aqueous alkali metal or alkaline earth metal oxide base.

Abstract: The present invention provides bicyclo[3.2.1]octyl amide derivatives of formula (I): wherein L, R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.

Abstract: A series of thiazolo[5,4-d]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.

Abstract: A series of monocyclic or bicyclic diamine-substituted thieno[2,3-d]pyrimidine and isothiazolo[5,4-d]pyrimidine derivatives are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.