Abstract: A predicted performance metric of a candidate advertisement in an advertising slot can be received and compared to a baseline predicted performance metric for the candidate advertisement. A target bid associated with the candidate advertisement can be adjusted based upon the comparison, and the adjusted bid can be submitted to an auction for the advertising slot.

Abstract: A hydrogen fueled powerplant including an internal combustion engine that drives a motor-generator, and has a two-stage turbocharger, for an aircraft. A control system controls the operation of the motor-generator to maintain the engine at a speed selected based on controlling the engine equivalence ratio. The control system controls an afterburner, an intercooler and an aftercooler to maximize powerplant efficiency. The afterburner also adds power to the turbochargers during high-altitude restarts. The turbochargers also include motor-generators that extract excess power from the exhaust.

Abstract: A high-altitude aircraft powerplant including an engine, a two-stage turbocharger having an intercooler and an aftercooler, a cryogenic hydrogen fuel source, and a cooling system including a hydrogen heat exchanger. Aided by a ram-air cooler that cools a coolant to a near-ambient temperature, the heat exchanger is configured to heat the hydrogen using the coolant, and to cool the coolant to a temperature well below the ambient temperature during high-altitude flight. The intercooler and aftercooler use the sub-ambient temperature coolant, as does a separate sensor. The ram-air cooler includes a front portion and a rear portion. The cooling system includes three cooling loops which respectively incorporate only the front portion, only the rear portion, and both portions of the ram-air cooler.

Abstract: A method for detecting a temporally oscillating source in digital video signals includes: using an imaging device to capture a sequence of input images of a scene; generating digital video signals from the sequence of input images; and processing the digital video signals using a recursive Infinite Impulse Response (IIR) filter technique based on a differentiated version of Goertzel's Algorithm to detect a temporally oscillating source in the digital video signals. In various embodiments, the method also includes generating a visual display of the scene including one or more graphical elements at least one of which pertains to a detected temporally oscillating source.

Abstract: The invention provides combinations of an ancillary compound of the formula (0): and a compound of the formula (I?): Also provided are crystalline forms of the constituent compounds, methods for making them and their uses in treating cancers.

Abstract: The invention provides combinations comprising (or consisting essentially of) one or more ancillary compound(s) and a compound of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxyg

Abstract: The invention provides a combination comprising a cytotoxic compound, a signalling inhibitor, an ancillary agent, or two or more further anti-cancer agents, and a compound having the formula (Ib): or salts or tautomers or N-oxides or solvates thereof; wherein X is a group R1-A-NR4—; A is a bond, C?O, NRg(C?O) or O(C?O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from fluorine, hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy (e.g.

Abstract: An advertiser specifies a conversion-based bid for a conversion event associated with an ad. If a conversion event occurs for the ad, an effective conversion-based bid can be adjusted by a risk premium associated with the ad. An account associated with the advertiser can be debited based upon the adjusted effective conversion-based bid.

Abstract: A high-altitude aircraft powerplant including an engine, a two-stage turbocharger having an intercooler and an aftercooler, a cryogenic hydrogen fuel source, and a cooling system including a hydrogen heat exchanger. Aided by a ram-air cooler that cools a coolant to a near-ambient temperature, the heat exchanger is configured to heat the hydrogen using the coolant, and to cool the coolant to a temperature well below the ambient temperature during high-altitude flight. The intercooler and aftercooler use the sub-ambient temperature coolant, as does a separate sensor. The ram-air cooler includes a front portion and a rear portion. The cooling system includes three cooling loops which respectively incorporate only the front portion, only the rear portion, and both portions of the ram-air cooler.

Abstract: The invention provides combinations comprising (or consisting essentially of) one or more ancillary compound(s) and a compound of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxyg

Abstract: A predicted performance metric of a candidate advertisement in an advertising slot can be received and compared to a baseline predicted performance metric for the candidate advertisement. A target bid associated with the candidate advertisement can be adjusted based upon the comparison, and the adjusted bid can be submitted to an auction for the advertising slot.

Abstract: A hydrogen fueled powerplant including an internal combustion engine that drives a motor-generator, and has a two-stage turbocharger, for an aircraft. A control system controls the operation of the motor-generator to maintain the engine at a speed selected based on controlling the engine equivalence ratio. The control system controls an afterburner, an intercooler and an aftercooler to maximize powerplant efficiency. The afterburner also adds power to the turbochargers during high-altitude restarts. The turbochargers also include motor-generators that extract excess power from the exhaust.

Abstract: The invention provides combinations comprising (or consisting essentially of) one or more ancillary compound(s) and a compound of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxyg

Abstract: The invention provides combinations of an ancillary compound and a compound which is a salt of 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea selected from the lactate and citrate salts and mixtures thereof. Also provided are crystalline forms of the salts, methods for making the salts and their uses in treating cancers. The invention further provides combinations of an ancillary compound and a compound of the formula (I) as defined in PCT/GB2004/002824 (WO 2005/002552) or a compound of the formula (I?) or a salt, solvate, tautomer or N-oxide thereof, wherein R1, E, A and M are as defined in the claims.

Abstract: A combination comprising (a) a compound of formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein X is R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C?O, NR9(C?O) or 0(C?O) wherein R9 is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1 to 3 carbon atoms; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or an optionally substituted C1-8 hydrocarbyl group wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy; or a C1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C1-4 alkoxy; R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C1-4 alkoxy; and (b) a compound of formul

Abstract: The use of a compound for the manufacture of a medicament for the prophylaxis or treatment of: A. a disease state or condition mediated by a kinase which is BCR-abl, VEGFR, PDGFR, EGFR, Flt3, JAK (e.g. JAK2 or JAK3), C-abl, PDK1, Chk (e.g. Cbk1 or Chk2), FGFR (e.g. FGFR3), Ret, Eph (e.g. EphB2 or EphB4), or Src (e.g. cSrc); or B. a cancer in which the cancer cells thereof contain a drug resistant kinase mutation which is: (a) a threonine gatekeeper mutation; or (b) a drug-resistant gatekeeper mutation; or (c) an imatinib resistant mutation; or (d) a nilotinib resistant mutation; or (e) a dasatinib resistant mutation; or (f) a T670I mutation in KIT; or (g) a T674I mutation in PDGFR; or (h) T790M mutation in EGFR; or (i) a T315I mutation in abl; or C. a cancer which expresses a mutated molecular target which is a mutated form of BCRabl, c-kit, PDGF, EGF receptor or ErbB2; or D.

Abstract: A media gateway to distribute network services and content throughout a home or residence is described. Generally, the media gateway includes a structured wiring panel, a services switch mounted within the structured wiring panel to receive network services from one or more network service providers, and to distribute the network services to a number of data outlets located at the residence. The media gateway may also include one or more patch panels mounted within the structured wiring panel to provide connectivity between the services switch and the data outlets, and an uninterruptable power supply (UPS) mounted within the structured wiring panel to supply backup electrical power to the services switch and/or one or more of the plurality of data outlets in the event of a main power failure.

Abstract: A data network to manage the distribution of network services and content throughout a home or residence is described. Generally, the data network includes a media gateway to receive, manage, and distribute services and content throughout the residence. The media gateway may include a structured wiring panel, a services switch to manage the network, and a communications module to provide an interface between the services switch and the residence.

Abstract: A communications management system includes a cabinet, a chassis, and a panel for mounting optical circuits. In one implementation, the chassis is coupled to the cabinet and slides outward from the cabinet and the panel is coupled to the chassis and pivots about an axis that is perpendicular to the direction that the chassis slides. A communications management system my include a cabinet with substantially parallel first and second surfaces. In one implementation, one of the surfaces contains a provision for attaching the cabinet to a second cabinet and a feature for passing a communications fiber from the cabinet to the second cabinet. A second communications management system includes panel for mounting optical circuits. In one implementation, the panel includes a feed adapter for terminating optical fibers that are in use and a parking lot for terminating optical fiber that are not in use.

Abstract: The invention provides a combination comprising an ancillary compound and a compound having the formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C?O, NR9(C?O) or 0(C?O) wherein R9 is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen, hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy; or a C1-4 hydrocarbyl group optionally substituted by