Abstract: Described herein are injectable corticosteroid-loaded microparticles, pharmaceutical composition thereof and methods for reducing inflammation or pain in a body compartment such as a joint, an epidural space, a vitreous body of an eye, a surgically created space, or a space adjacent to an implant.

Abstract: Described herein are sustained release formulations of polymer-coated local anesthetic agents, and methods for using the same to relieve or manage pain, including postsurgical pain.

Abstract: Described herein are injectable corticosteroid-loaded microparticles, pharmaceutical composition thereof and methods for reducing inflammation or pain in a body compartment such as a joint, an epidural space, a vitreous body of an eye, a surgically created space, or a space adjacent to an implant.

Abstract: Described herein are sustained release formulations of polymer-coated local anesthetic agents, and methods for using the same to relieve or manage pain, including postsurgical pain.

Abstract: Provided is an epidural device configured to inhibit or substantially or completely prevent further progression of an epidural needle upon entry of the needle into the epidural space. When the needle is inserted into the ligamentum of the patient's back, the device may be pressurized with fluid using the resistance of the dense ligament to maintain pressure. This pressurization may lock a pushing mechanism in place relative to the needle such that the pushing mechanism can be used to advance the needle. Once the epidural space is reached, the fluid (e.g., saline or air) enters the epidural space, and the release of pressure may cause the trigger mechanism to disengage from the sliding pusher, allowing the pusher to slide along the body of the construct. The device thus may provide the ability to detect the epidural space using pressure loss while preventing the needle from advancing into the dura once the space is reached.

Abstract: Provided is an epidural device configured to inhibit or substantially or completely prevent further progression of an epidural needle upon entry of the needle into the epidural space. When the needle is inserted into the ligamentum of the patient's back, the device may be pressurized with fluid using the resistance of the dense ligament to maintain pressure. This pressurization may lock a pushing mechanism in place relative to the needle such that the pushing mechanism can be used to advance the needle. Once the epidural space is reached, the fluid (e.g., saline or air) enters the epidural space, and the release of pressure may cause the trigger mechanism to disengage from the sliding pusher, allowing the pusher to slide along the body of the construct. The device thus may provide the ability to detect the epidural space using pressure loss while preventing the needle from advancing into the dura once the space is reached.

Abstract: Provided is an epidural device configured to inhibit or substantially or completely prevent further progression of an epidural needle upon entry of the needle into the epidural space. When the needle is inserted into the ligamentum of the patient's back, the device may be pressurized with fluid using the resistance of the dense ligament to maintain pressure. This pressurization may lock a pushing mechanism in place relative to the needle such that the pushing mechanism can be used to advance the needle. Once the epidural space is reached, the fluid (e.g., saline or air) enters the epidural space, and the release of pressure may cause the trigger mechanism to disengage from the sliding pusher, allowing the pusher to slide along the body of the construct. The device thus may provide the ability to detect the epidural space using pressure loss while preventing the needle from advancing into the dura once the space is reached.

Abstract: Described herein are sustained release formulations of polymer-coated local anesthetic agents, and methods for using the same to relieve or manage pain, including postsurgical pain.

Abstract: Described herein are injectable corticosteroid-loaded microparticles, pharmaceutical composition thereof and methods for reducing inflammation or pain in a body compartment such as a joint, an epidural space, a vitreous body of an eye, a surgically created space, or a space adjacent to an implant.

Abstract: Described herein are injectable corticosteroid-loaded microparticles, pharmaceutical composition thereof and methods for reducing inflammation or pain in a body compartment such as a joint, an epidural space, a vitreous body of an eye, a surgically created space, or a space adjacent to an implant.

Abstract: Described herein are sustained release formulations of polymer-coated local anesthetic agents, and methods for using the same to relieve or manage pain, including postsurgical pain.

Abstract: Described herein are injectable corticosteroid-loaded microparticles, pharmaceutical composition thereof and methods for reducing inflammation or pain in a body compartment such as a joint, an epidural space, a vitreous body of an eye, a surgically created space, or a space adjacent to an implant.

Abstract: Described herein are injectable corticosteroid-loaded microparticles, pharmaceutical composition thereof and methods for reducing inflammation or pain in a body compartment such as a joint, an epidural space, a vitreous body of an eye, a surgically created space, or a space adjacent to an implant.

Abstract: Described herein are injectable corticosteroid-loaded microparticles, pharmaceutical composition thereof and methods for reducing inflammation or pain in a body compartment such as a joint, an epidural space, a vitreous body of an eye, a surgically created space, or a space adjacent to an implant.

Abstract: Described herein are injectable corticosteroid-loaded microparticles, pharmaceutical composition thereof and methods for reducing inflammation or pain in a body compartment such as a joint, an epidural space, a vitreous body of an eye, a surgically created space, or a space adjacent to an implant.

Abstract: Described herein are extended release composite film comprising a drug-loaded membrane coated with porous coatings that is capable of localized release of drug (e.g., antibiotics) for surgical prophylaxis.

Abstract: Described herein are injectable drug-loaded microparticles, pharmaceutical composition thereof and methods for using the same in a body compartment or for systemic administration.

Abstract: A syringe is provided having a hub with an orifice, first and second barrels having an interior surface to form respective lumens, a valve, and a test indicator. The first and second barrels slideably receive respective first and second plungers for movement therein. The valve is operable to provide a fluidly communicative path between the orifice of the hub and the first and second barrel lumens. The test indicator is responsive to at least one characteristic of a bodily fluid, the test indicator positioned to be exposed to any bodily fluid drawn into the first barrel lumen and visible from an exterior of the first barrel.

Abstract: Described herein are injectable corticosteroid-loaded microparticles, pharmaceutical composition thereof and methods for reducing inflammation or pain in a body compartment such as a joint, an epidural space, a vitreous body of an eye, a surgically created space, or a space adjacent to an implant.