Abstract: A heat exchanger that comprises a plurality of small channels that are arranged around a cross-sectional perimeter such that the sides of the small channels are touching to create bigger channels running parallel to the small channels. To this end, embodiments of the present invention have a heat exchanger matrix where the structure of the large channels is entirely comprised by the structure of the smaller channels resulting in a more compact, more efficient heat exchanger.

Abstract: A heat exchanger assembly that in a preferred embodiment comprises: an inlet duct lower wall interfacing with a bypass duct; an outlet duct lower wall interfacing with a bypass duct; a heat exchanger coupled between the inlet duct lower wall and the outlet duct lower wall wherein the heat exchanger is at a compound angle with respect to an inlet duct air flow direction; and a fairing coupled to the top of the heat exchanger wherein the fairing forms the inlet duct upper wall and the outlet duct upper wall.

Abstract: This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: A system for growing plants and monitoring the growth of plants, comprising a gardening system and a server. The gardening system comprises a frame that defines a housing for receiving a tray of plants. The gardening system also has a lighting subsystem and watering subsystem to provide light and water to the plants. Sensors and cameras of the gardening system may capture data corresponding to the conditions of the gardening system and health of the plant. Based on the captured data, the server may use machine learning to determine optimal plant growing thresholds, and may send a control command to a controller of the gardening system to change one or more conditions of the gardening system. The plants grown by the system may be nutritious, and the bioavailability of the nutrients of the plants may be increased.

Abstract: An aft heat shield for a fuel nozzle tip includes: an annular shield wall; an annular shield flange extending radially outward from an aft end of the shield wall; an annular baffle flange surrounding the conical section, and disposed such that an axial gap is defined between the shield flange and the baffle flange, the baffle flange including a radially outer rim extending axially forward therefrom; and a plurality of impingement cooling holes passing through the baffle flange and oriented to as to direct air flow towards the shield wall.

Abstract: A wearable, garment-supported air-purification system has a source of filtered forced air communicating with a face mask filter for securing over a user's mouth and nose. The source of filtered forced air is supported in the garment, such as a scarf, at a location spaced from the face filter mask. The source of filtered forced air communicates with the face filter mask through a closed air channel such as a flexible hose.

Abstract: A tissue marking device enables the deployment of a hook to mark a location within a breast. The deployment is performed by inserting a needle in tissue until it arrives at a target location and pressing on the end of a rod that embeds the hook in the tissue. A thread is attached to the hook and is left exposed to facilitate locating the hook.

Abstract: Heat exchanger assemblies including turning vanes are taught herein. In preferred embodiments, the heat exchanger assembly comprises: an inlet duct; a heat exchanger coupled to the inlet duct and a plurality of turning vanes coupled to the heat exchanger and protruding into the inlet duct. The intake plane of the heat exchanger is at an angle between 0 degrees and 90 degrees to the primary flow direction of the inlet duct. The plurality of turning vanes comprise: a straight leading edge of length L that is parallel to the primary flow direction of the inlet duct; a convex lower surface that transitions a bottom of the leading edge to an upper wall of a lower channel of the heat exchanger; and a concave upper surface that transitions a distal point of the turning vane to a second channel of the heat exchanger.

Abstract: Heat exchanger designs incorporating helixes and methods for making heat exchangers incorporating helixes are provided herein. In preferred embodiments, the heat exchanger comprises a plurality of fluid A channels each formed from a tube spiraled into a helix to form a plurality of helixes wherein the plurality of helixes are arranged in a hexagonal packing arrangement in a packing plane perpendicular to the axes of rotation of the plurality of helixes and wherein the pitch of each helix in the plurality of helixes is matched to an exterior diameter of the tube such that each helix in the plurality of helixes has a sealed interior that forms a plurality of fluid B channels.

Abstract: This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.

Abstract: The present invention provides cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway along with their use in therapeutic applications as described herein.

Abstract: The present invention provides an electronic data document (EDD) and related system and method for use in a computerized clinical trial verification system. In an exemplary embodiment, the EDD is authenticated by the creator and validated by the receiver, and comprises an image of a source document (SD) that comprises a masked record of at least one interaction between a clinical trial investigator and a patient enrolled in a clinical trial, at least one revealed portion of the SD that includes evidence relevant to at least one question in a clinical trial questionnaire, and at least one annotation connecting the revealed portion to the at least one question. The present invention provides a computerized system and method for allowing a clinical trial investigator to answer questions from a clinical trial questionnaire pertinent to a clinical trial of a medical treatment using encrypted and partially masked electronic documents comprising images of original patient records.

Abstract: The present disclosure is directed at systems and methods for detecting ransomware infection in filesystems. These systems and methods may enable a computer user to detect a ransomware infection within a filesystem utilizing a snapshot image-based backup. According to some embodiments, the disclosed systems and methods analyze metadata describing the contents of an examined filesystem embodied in a Master File Table (MFT). Also according to some embodiments, the disclosed systems and methods compute an entropy associated with an extracted sample of files to distinguish between infected and uninfected file systems. Relative to other techniques, the disclosed systems/methods can decrease the time and/or computational resources required to detect ransomware, while also decreasing false positives and false negatives.

Abstract: This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: A method includes: initializing a list of token embeddings, each of the token embeddings corresponding to a tokenized word from text in a corpus of text; generating a graph for a group of consecutive words s from the text, said graph including binary relations between pairs of tokenized words of the group of consecutive words; selecting the token embeddings representing the words of the group of consecutive words from the list of token embeddings; computing a tensor of binary relations as the product between a matrix of the selected token embeddings and a tensor representing discourse relations, the computed tensor representing the binary relations between the pairs of tokenized words; computing a loss using the computed tensor; optimizing the list of token embeddings using the computed loss. The above may be repeated until the computed loss is within a predetermined range.

Abstract: The present invention provides an electronic data document (EDD) and related system and method for use in a computerized clinical trial verification system. In an exemplary embodiment, the EDD is authenticated by the creator and validated by the receiver, and comprises an image of a source document (SD) that comprises a masked record of at least one interaction between a clinical trial investigator and a patient enrolled in a clinical trial, at least one revealed portion of the SD that includes evidence relevant to at least one question in a clinical trial questionnaire, and at least one annotation connecting the revealed portion to the at least one question. The present invention provides a computerized system and method for allowing a clinical trial investigator to answer questions from a clinical trial questionnaire pertinent to a clinical trial of a medical treatment using encrypted and partially masked electronic documents comprising images of original patient records.

Abstract: The present invention provides an electronic data document (EDD) and related system and method for use in a computerized clinical trial verification system. In an exemplary embodiment, the EDD is authenticated by the creator and validated by the receiver, and comprises an image of a source document (SD) that comprises a masked record of at least one interaction between a clinical trial investigator and a patient enrolled in a clinical trial, at least one revealed portion of the SD that includes evidence relevant to at least one question in a clinical trial questionnaire, and at least one annotation connecting the revealed portion to the at least one question. The present invention provides a computerized system and method for allowing a clinical trial investigator to answer questions from a clinical trial questionnaire pertinent to a clinical trial of a medical treatment using encrypted and partially masked electronic documents comprising images of original patient records.

Abstract: Systems and techniques for self service delivery of content stored on removable media. A self service terminal stores a plurality of titles in a repository, and copies of titles are stored to removable media devices maintained in the self service terminal. In response to a user selection of an available title made during a transaction, a removable media device storing a copy of the selected title is delivered to the user. Anticipated demand is estimated and titles are stored to removable devices as needed to maintain an inventory to meet the estimated demand, including overwriting existing titles already stored on removable media, and overwriting returned media as needed.

Abstract: A device may identify a plurality of sources for outputs that the device is configured to provide. The plurality of sources may include at least one of a particular application in the device, an operating system of the device, a particular area within a display of the device, or a particular graphical user interface object. The device may also assign a set of distinct voices to respective sources of the plurality of sources. The device may also receive a request for speech output. The device may also select a particular source that is associated with the requested speech output. The device may also generate speech having particular voice characteristics of a particular voice assigned to the particular source.

Abstract: This invention relates to the biosynthetic production of macrocyclic molecules from linear precursor peptides that contain highly truncated C terminal recognition sequences of 10 or fewer residues using prolyl oligopeptidase (POP) macrocyclases. This may be useful for example in the biosynthetic production of macrocyclic molecules. Methods and kits for the production of macrocyclic molecules, as well as libraries and methods of screening, are provided.