Patents by Inventor James A. Henshilwood

James A. Henshilwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLINE FORMS OF (R)-8-CHLORO-1-METHYL- 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE
    Publication number: 20160009654
    Abstract: The present invention is directed to crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, compositions containing the same and uses thereof.
    Type: Application
    Filed: March 2, 2015
    Publication date: January 14, 2016
    Inventors: Rajesh Kumar Agarwal, William L. Betts, III, James A. Henshilwood, Yuan-Hon Kiang, Noah Post
  • Crystalline forms of ()-8-chloro-1-methyl-2,3,4,5-tetrahydro-1-3-benzazepine hydrochloride
    Patent number: 8980881
    Abstract: The present invention is directed to crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, compositions containing the same and uses thereof.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: March 17, 2015
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: Rajesh K. Agarwal, William L. Betts, III, James A. Henshilwood, Yuan-Hon Kiang, Noah Post
  • Crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-thtrahydro-1H-3-benzazepine hydrochloride
    Patent number: 8697686
    Abstract: The present invention is directed to crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, compositions containing the same and uses thereof.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: April 15, 2014
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: Rajesh K. Agarwal, William L. Betts, III, James A. Henshilwood, Yuan-Hon Kiang, Noah Post
  • CRYSTALLINE FORMS OF (R)-8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE
    Publication number: 20140051684
    Abstract: The present invention is directed to crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, compositions containing the same and uses thereof.
    Type: Application
    Filed: September 14, 2012
    Publication date: February 20, 2014
    Inventors: Rajesh K. Agarwal, William L. Betts, III, James A. Henshilwood, Yuan-Hon Kiang, Noah Post
  • CRYSTALLINE FORMS OF (R)-8-CHLORO-1-METHYL-2,3,4,5-THTRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE
    Publication number: 20120264743
    Abstract: The present invention is directed to crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, compositions containing the same and uses thereof.
    Type: Application
    Filed: March 21, 2012
    Publication date: October 18, 2012
    Inventors: Rajesh K. Agarwal, William L. Betts, III, James A. Henshilwood, Yuan-Hon Kiang, Noah Post
  • Crystalline forms of ()-8-chloro-1-methyl-2,3,4,5-tetrahydro-1-3-benzazepine hydrochloride
    Patent number: 8168624
    Abstract: The present invention is directed to crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, compositions containing the same, preparations, and uses thereof.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: May 1, 2012
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: Rajesh K. Agarwal, William L. Betts, III, James A. Henshilwood, Yuan-Hon Kiang, Noah Post
  • Crystalline Forms Of (R)-8-Chloro-1-Methyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine Hydrochloride
    Publication number: 20100004223
    Abstract: The present invention is directed to crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, compositions containing the same, preparations, and uses thereof.
    Type: Application
    Filed: December 20, 2005
    Publication date: January 7, 2010
    Applicant: Arena Phamaceuticals, Inc.
    Inventors: Rajesh K. Agarwal, William l. Betts, James A. Henshilwood, Yuan-Hon Kiang, Noah Post
  • Oxidative process and products thereof
    Patent number: 6271371
    Abstract: The subject invention concerns a process for the preparation of a compound of formula (2), which comprises phenolic oxidation of a compound of formula (1) wherein X1 and X2 are independently selected from H or a protecting group for the phenolic function, e.g. acyl or trialkylsilyl; groups A1, A2, B1, B2 and Y are selected so as to render the nitrogen atom non-basic; Z is a blocking group, e.g. Br or t-butyl; and R is H, alkyl, aryl, or arylalkyl, and wherein the process is carried out in a two-phase liquid system comprising an aqueous base and an organic solvent having a dielectric constant below 4.8.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: August 7, 2001
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: James Henshilwood, Nicholas Bernard Johnson
  • Oxidative process for preparing narwedine derivatives
    Patent number: 6084094
    Abstract: The subject invention concerns a process for the preparation of a compound of formula (2), which comprises phenolic oxidation of a compound of formula (1) wherein X.sup.1 and X.sup.2 are independently selected from H or a protecting group for the phenolic function, e.g. acyl or trialkylsilyl; groups A.sup.1, A.sup.2, B.sup.1, B.sup.2 and Y are selected so as to render the nitrogen atom non-basic; Z is a blocking group, e.g. Br or t-butyl; and R is H, C.sub.1-20 alkyl, C.sub.3-20 aryl, C.sub.4-20 arylalkyl, and wherein the process is carried out in a two-phase liquid system comprising an aqueous base and an organic solvent having a dielectric constant below 4.8.
    Type: Grant
    Filed: July 16, 1997
    Date of Patent: July 4, 2000
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: James Henshilwood, Nicholas Bernard Johnson