Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: Disclosed herein are macrocyclic compounds that inhibit the binding of KRas. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the KRas inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia, lung cancer, colorectal cancer, pancreatic cancer, and other diseases or conditions dependent on KRas interaction.

Abstract: A system for cross-domain identity management (SCIM) proxy service is described. A first SCIM endpoint receives, from a first SCIM client, a first message that includes a SCIM resource. The first SCIM endpoint is associated with a customer of the SCIM proxy service. The SCIM proxy service is configured as a first SCIM service provider for the first SCIM client. The first message is validated. The first SCIM proxy service determines that a third-party application is in scope for the SCIM resource, where the SCIM proxy service is configured as a second SCIM client for the third-party application. The SCIM proxy service transforms the SCIM resource to create a transformed SCIM resource that is applicable for the third-party application. The SCIM proxy service transmits a second message to a second SCIM endpoint of the third-party application, the second message including the transformed SCIM resource.

Abstract: Systems and methods are disclosed for coordinating and executing bidirectional energy transfer events between electrified vehicles and one or more participating electrified recreational vehicles. Energy may be transferred from an electrified vehicle to one or more electrified recreational vehicles, from the one or more electrified recreational vehicles to the electrified vehicle, or both during bidirectional energy transfer events. The proposed systems and methods may further be configured to provide various charging configurations between the electrified vehicle and the one or more electrified recreational vehicles.

Abstract: A method for determining authenticity of a security device of a component in an imaging device includes receiving, by the security device, an authentication challenge including one or more commands and executing, by the security device, the one or more commands in response to receiving the authentication challenge. A magnetic field profile is generated based on current drawn by the security device from a power source while the security device is executing the one or more commands, the generated magnetic field profile indicating an authentication response of the security device to the authentication challenge for use in determining authenticity of the security device.

Abstract: An alignment aid for a golf club includes a centerline marker for marking a centerline of a shaft of a golf club, one or more alignment angle markers and an angle indicator configured to couple to the centerline marker at a first end and one of the one or more alignment angle markers at a second opposite end, wherein the angle indicator indicates a preselected club angle for a user. The centerline marker, the one or more alignment angle markers and the angle indicator can comprise one or more stickable decals.

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

Abstract: A resonator and/or MEMS device is provided with a flexible suspension mount to reduce mechanical stress and/or interference arising from other electrical components. In one illustrative embodiment, the flexible suspension mount can be configured as one or more metallic springs that provide for electrical connection as well as for specific spring and dampening coefficients. In another illustrative material, techniques can be use which change spring and/or dampening coefficients at a particular point in the manufacturing/assembly/distribution process, optionally before device characterization and/or programming.

Abstract: A marker delivery assembly for a biopsy device includes an integration module and a marker delivery module. The integration module includes a connector defining a cavity and a neck that extends outwardly from the cavity in a longitudinal direction. A transmission cover having a shaft is disposed about the neck, and further includes a spindle gear and a drum gear. A bevel drum is rotatably coupled to the drum gear and a pushrod is engaged to the bevel drum. The marker delivery module includes a marker housing releasably coupled to the integration module. A marker delivery cartridge engages the marker housing, and is rotatable between an initial position and a delivery position. The pushrod extends through the marker delivery cartridge and forces at least one marker into the biopsy device.

Abstract: A liquid lens includes a substrate, a transparent elastic membrane forming a cavity with the substrate, and a transparent fluid filling the cavity between the substrate and the membrane. The membrane has a pre-distorted, rotationally asymmetric shape in absence of the fluid in the cavity. When the cavity is filled with the fluid and the substrate is disposed vertically w.r.t. gravity at a pre-defined clocking angle, the membrane adopts a substantially rotationally symmetric shape due to elasticity of the membrane counteracting gravity exerting a downward force on the fluid in the cavity, reducing the effect of the gravity sag on optical performance of the liquid lens.

Abstract: Techniques for generating synthetic data are described. An exemplary approach includes receiving one or more requests to generate synthetic data based on a first dataset; generating the synthetic dataset is generated according to the request by choosing a set of synthetic datapoints between pairs of datapoints of the first dataset along a line connecting them while sampling a likely value of a local probability distribution; and providing the synthetic dataset as configured by the request.

Abstract: A liquid lens includes a substrate, a transparent elastic membrane forming a cavity with the substrate, and a transparent fluid filling the cavity between the substrate and the membrane. The membrane has a pre-distorted, rotationally asymmetric shape in absence of the fluid in the cavity. When the cavity is filled with the fluid and the substrate is disposed vertically w.r.t. gravity at a pre-defined clocking angle, the membrane adopts a substantially rotationally symmetric shape due to elasticity of the membrane counteracting gravity exerting a downward force on the fluid in the cavity, reducing the effect of the gravity sag on optical performance of the liquid lens.

Abstract: A window assembly for attachment to a frame of a vehicle includes a window having a top, a bottom, sides, an outer surface, and an inner surface. A height of the window extends from the top to the bottom of the window. A width of the window extends between the sides of the window. A thickness of the window extends between the outer and inner surfaces. The window defines a plurality of slots. A clamp is securable to the frame of the vehicle for mounting the window assembly to the vehicle. A bolt is extendable through the clamp and window to couple the window to the clamp and frame. A fastener is engageable with the bolt to secure the window assembly to the frame.

Abstract: A performance metrics of a receiver is obtained using frames of an application hosted by a server that are received via a network. The one or more performance metrics include information indicative of a current occupancy of a frame buffer corresponding to the receiver and information indicative of a target occupancy of the frame buffer corresponding to the receiver. The frame buffer of the receiver is used to queue frames of the application for display. A frame rate associated with rendering at least one next frame of the application is adjusted using the one or more performance metrics of the receiver to control population of the frame buffer. Subsequent frames of the application hosted by the server are rendered using the adjusted frame rate. Upon rendering the subsequent frames, the server sends the subsequent frames to the receiver for display.

Abstract: A glass ceramic article including a lithium disilicate crystalline phase, a petalite crystalline phased, and a residual glass phase. The glass ceramic article has a warp (?m)<(3.65×10?9/?m×diagonal2) where diagonal is a diagonal measurement of the glass ceramic article in ?m, a stress of less than 30 nm of retardation per mm of glass ceramic article thickness, a haze (%)<0.0994t+0.12 where t is the thickness of the glass ceramic article in mm, and an optical transmission (%)>0.91×10(2-0.03t) of electromagnetic radiation wavelengths from 450 nm to 800 nm, where t is the thickness of the glass ceramic article in mm.

Abstract: Techniques for identifying and triaging issues associated with a vehicle in order to resolve the issues are described. The techniques may include receiving log data associated with a vehicle and generating an event timeline based at least in part on the log data. The event timeline may comprise a time-ordered record of events associated with operations of the vehicle. The techniques may also include identifying, based at least in part on an event included in the event timeline, a first occurrence of an issue associated with the vehicle. In some instances, a correlation may be determined between the first occurrence of the issue and a second occurrence of the issue, and a cause of the issue may also be determined based at least in part on the correlation. In some examples, the second occurrence of the issue may appear in the event timeline or another event timeline.

Abstract: Methods and systems for detecting dynamic objects using a mesh network of nodes coupled to cameras are disclosed. The system can receive sequences of frames captured by a first capture device having a first pose and a second capture device having a second pose, and track objects over time across the first sequence of frames and the second sequence of frames. The system can map the objects to three-dimensional (3D) positions in a 3D coordinate space based on correspondences between the indications of the objects. The system can determine a 3D displacement of a subset of the 3D points, and generate a 3D volume surrounding the subset. The system can use the 3D volume to classify and predict a trajectory for the dynamic object, as well as determine a risk the dynamic object poses to a protected volume in the 3D coordinate space.

Abstract: Disclosed are antiviral coatings comprising silver nanoparticles, methods of their preparation and uses thereof. The antiviral coatings include silver nanoparticles bound to polyurethane polymers, acrylic polymers, and polyols bound to via the respective functional groups. The antiviral coatings have a very low silver leach rate. The silver nanoparticles are formed by reduction of silver ions by the functional groups. Further, the silver nanoparticles are stabilised by the interactions with the functional groups.

Abstract: Methods and apparatus for a map tool displaying a three-dimensional view of a map based on a three-dimensional model of the surrounding environment. The three-dimensional map view of a map may be based on a model constructed from multiple data sets, where the multiple data sets include mapping information for an overlapping area of the map displayed in the map view. For example, one data set may include two-dimensional data including object footprints, where the object footprints may be extruded into a three-dimensional object based on data from a data set composed of three-dimensional data. In this example, the three-dimensional data may include height information that corresponds to the two-dimensional object, where the height may be obtained by correlating the location of the two-dimensional object within the three-dimensional data.

Abstract: A server transmits to a third-party application a request for a resource that is received from a client. The server receives an authentication request from the client device that has been generated by the third-party application. The server transmits an identity provider selection page to the client device that allows the client device to select an identity provider. The server causes the client device to transmit a second authentication request to a selected identity provider. The server receives an authentication response that was generated by the identity provider that includes the identity of the user. The server enforces access rule(s) including identity-based rule(s) and/or non-identity based rule(s). If the user is permitted to access the third-party application, the server causes an authentication response to be transmitted from the client device to the third-party application that indicates the user has successfully authenticated.