Abstract: This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein L1, L2, R1, R2, R3 and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: A method includes providing audio signals of an interaction between a plurality of human speakers, the speakers speaking into electronic devices to record the audio signals. The audio signals, which are optionally combined, include agent audio and subject audio. The method further includes automatically processing the audio signals to generate a speaker separated natural language transcript of the interaction from the audio signals. For each identified question, a subject response is identified. From the agent text, it is determined whether the question asked by the at least one agent is an open question or a closed question. A decision engine is used to determine the veracity of the subject response and the subject response is flagged if the indicia of the likelihood of deception in the subject response exceeds a predetermined value.

Abstract: A computing device retrieves a stabilized weight and a weight-based item count for one or more items to be purchased. Responsive to retrieving the stabilized weight, the computing device retrieves an image-based item count and an expected weight based on the image-based item count for the one or more items to be purchased. The computing device selects between authorizing and blocking checkout of the one or more items based on the weight-based item count, the image-based item count, the stabilized weight, and the expected weight.

Abstract: A method includes providing audio signals of an interaction between a plurality of human speakers, the speakers speaking into electronic devices to record the audio signals. The audio signals, which are optionally combined, include agent audio and subject audio. The method further includes automatically processing the audio signals to generate a speaker separated natural language transcript of the interaction from the audio signals. For each identified question, a subject response is identified. From the agent text, it is determined whether the question asked by the at least one agent is an open question or a closed question. A decision engine is used to determine the veracity of the subject response and the subject response is flagged if the indicia of the likelihood of deception in the subject response exceeds a predetermined value.

Abstract: This disclosure relates to a device for applying a neural stimulus. A battery supplies electrical energy at a battery voltage and an electrode applies the electrical energy to neural tissue. A circuit measures the nervous response of the tissue and a voltage converter receives the electrical energy from the battery and controls a voltage applied to the electrode based on the measured nervous response of the tissue. This direct voltage control is energy efficient because losses across a typical current mirror are avoided. Further, the control based on the measured nervous response leads to automatic compensation of impedance variation due to in-growth or change in posture. As a result, the stimulation results in a desired neural response.

Abstract: A method includes providing audio signals of an interaction between a plurality of human speakers, the speakers speaking into electronic devices to record the audio signals. The audio signals, which are optionally combined, include agent audio and subject audio. The method further includes automatically processing the audio signals to generate a speaker separated natural language transcript of the interaction from the audio signals. For each identified question, a subject response is identified. From the agent text, it is determined whether the question asked by the at least one agent is an open question or a closed question. A decision engine is used to determine the veracity of the subject response and the subject response is flagged if the indicia of the likelihood of deception in the subject response exceeds a predetermined value.

Abstract: A drill bit (100) having a longitudinal axis (101) and to be rotated about the axis (101) in a drilling direction (102) to perform a drilling operation. The drill bit (100) comprises a body (120) having a longitudinal length with a proximal end (121) and a distal end (122). The body (120) has a diameter. A tapered tip (110) extends from the proximal end (121) and terminates in an apex (111) at an end of the drill bit (100). The drill bit (100) also comprises a plurality of flutes (140) with each flute (140) extending helically along the body (120) into the tip (110). The drill bit (100) also comprises a land (150) between each of the flutes (140) and extends to the tip (110). The drill bit (100) also comprises a plurality of tip faces (190) on the tip (110) and extends from a corresponding land (150) to the apex (111), where each of the tip faces (190) has a tip face leading edge (173) and a tip face trailing edge (174).

Abstract: This disclosure relates to a device for applying a neural stimulus. A battery supplies electrical energy at a battery voltage and an electrode applies the electrical energy to neural tissue. A circuit measures the nervous response of the tissue and a voltage converter receives the electrical energy from the battery and controls a voltage applied to the electrode based on the measured nervous response of the tissue. This direct voltage control is energy efficient because losses across a typical current mirror are avoided. Further, the control based on the measured nervous response leads to automatic compensation of impedance variation due to in-growth or change in posture. As a result, the stimulation results in a desired neural response.

Abstract: A drill bit (100) having a longitudinal axis (101) and to be rotated about the axis (101) in a drilling direction (102) to perform a drilling operation. The drill bit (100) comprises a body (120) having a longitudinal length with a proximal end (121) and a distal end (122). The body (120) has a diameter. A tapered tip (110) extends from the proximal end (121) and terminates in an apex (111) at an end of the drill bit (100). The drill bit (100) also comprises a plurality of flutes (140) with each flute (140) extending helically along the body (120) into the tip (110). The drill bit (100) also comprises a land (150) between each of the flutes (140) and extends to the tip (110). The drill bit (100) also comprises a plurality of tip faces (190) on the tip (110) and extends from a corresponding land (150) to the apex (111), where each of the tip faces (190) has a tip face leading edge (173) and a tip face trailing edge (174).

Abstract: An airtrap for a medical or physiological fluid in one embodiment includes a conical housing having a radius that increases from its top to its bottom when the housing is positioned for operation; a medical or physiological fluid inlet located at an upper portion of the conical housing; a medical or physiological fluid outlet located at a lower portion of the conical housing, the inlet and the outlet positioned and arranged so that medical or physiological fluid spirals in an increasing arc around an inside of the conical housing downwardly from the inlet to the outlet; and a gas collection area located at an upper portion of the conical housing. In another embodiment, the airtrap is shaped like a seahorse having a head section and a tail section. Any of the airtraps herein may be used for example in blood sets, peritoneal dialysis cassette tubing, and drug delivery sets.

Abstract: An airtrap for a medical or physiological fluid in one embodiment includes a conical housing having a radius that increases from its top to its bottom when the housing is positioned for operation; a medical or physiological fluid inlet located at an upper portion of the conical housing; a medical or physiological fluid outlet located at a lower portion of the conical housing, the inlet and the outlet positioned and arranged so that medical or physiological fluid spirals in an increasing arc around an inside of the conical housing downwardly from the inlet to the outlet; and a gas collection area located at an upper portion of the conical housing. In another embodiment, the airtrap is shaped like a seahorse having a head section and a tail section. Any of the airtraps herein may be used for example in blood sets, peritoneal dialysis cassette tubing, and drug delivery sets.

Abstract: An electric vehicle system includes a battery management system that optimizes the performance and useful life of vehicle batteries by selecting the optimal batteries in an inventory for each electric vehicle mission based on the mission energy requirements, the energy storage capacities of batteries, and the predicted performance degradation of batteries.

Abstract: An airtrap for a medical or physiological fluid in one embodiment includes a conical housing having a radius that increases from its top to its bottom when the housing is positioned for operation; a medical or physiological fluid inlet located at an upper portion of the conical housing; a medical or physiological fluid outlet located at a lower portion of the conical housing, the inlet and the outlet positioned and arranged so that medical or physiological fluid spirals in an increasing arc around an inside of the conical housing downwardly from the inlet to the outlet; and a gas collection area located at an upper portion of the conical housing. In another embodiment, the airtrap is shaped like a seahorse having a head section and a tail section. Any of the airtraps herein may be used for example in blood sets, peritoneal dialysis cassette tubing, and drug delivery sets.

Abstract: A weight determining system is for use with a non-singulated and non-spaced arrangement of items on a conveyor. The system includes an array of load cells, a scanning apparatus, and processors. Each of the items bears upon one or more of the load cells. Each of the load cells bears one or more of the items, and generates load data associated with them. The scanning apparatus generates scan data for the arrangement of the items on the conveyor. Based on the scan data, the processors: apportion the load data from each load cell to the items bearing on it; allocate to each item the load data apportioned from the various load cells; and determine a weight for each item. Also disclosed are a corresponding weight determining method, as well as a computer readable medium containing executable instructions to encode the processors to perform as aforesaid.

Abstract: An adjustable speed control system includes a reader, databases, processors and a conveyor controller. The databases store data concerning conveyor stops and failed attempts by the reader to identify conveyed items. Based on the failed attempts and the conveyor stops, the processors calculate an optimal speed of the conveyor. The controller adjusts the conveyor speed towards the optimal speed to increase the conveyed items successfully identified by the reader. Also disclosed are a corresponding method and computer readable medium on which is stored instructions to, upon execution, adjustably control the conveyor speed.

Abstract: An adjustable speed control system includes a reader, databases, processors and a conveyor controller. The databases store data concerning conveyor stops and failed attempts by the reader to identify conveyed items. Based on the failed attempts and the conveyor stops, the processors calculate an optimal speed of the conveyor. The controller adjusts the conveyor speed towards the optimal speed to increase the conveyed items successfully identified by the reader. Also disclosed are a corresponding method and computer readable medium on which is stored instructions to, upon execution, adjustably control the conveyor speed.

Abstract: An adjustable speed control system includes a reader, databases, processors and a conveyor controller. The databases store data concerning conveyor stops and failed attempts by the reader to identify conveyed items. Based on the failed attempts and the conveyor stops, the processors calculate an optimal speed of the conveyor. The controller adjusts the conveyor speed towards the optimal speed to increase the conveyed items successfully identified by the reader. Also disclosed are a corresponding method and computer readable medium on which is stored instructions to, upon execution, adjustably control the conveyor speed.

Abstract: A system includes a sender application transmitting sender data for delivery items. A portable device carried by a courier transmits courier data for the items. Courier processors automatically generate a manifest which reconciles the sender data and courier data for each item. A courier database electronically stores the manifest. The system and included portable device, along with a corresponding method and computer readable medium, facilitate cost recovery for the items delivered by the courier.

Abstract: An adjustable speed control system includes a reader, databases, processors and a conveyor controller. The databases store data concerning conveyor stops and failed attempts by the reader to identify conveyed items. Based on the failed attempts and the conveyor stops, the processors calculate an optimal speed of the conveyor. The controller adjusts the conveyor speed towards the optimal speed to increase the conveyed items successfully identified by the reader. Also disclosed are a corresponding method and computer readable medium on which is stored instructions to, upon execution, adjustably control the conveyor speed.

Abstract: A cart moves items within a facility, each having an identification tag. The cart includes a carriage, a scale, a reader, and processors. The scale measures a cumulative weight of the items on the carriage. The reader reads the tags of the items. The processors determine a weight for each item by a change in the cumulative weight after its transfer to or from the carriage. The weight is stored in a database in association with each item. There is also disclosed a related system and method. Preferably, the cart is located, and its location is applied to each item carried thereby to track the items within the facility.