Abstract: This specification describes an ion exchange membrane and a method of making it. The membrane may be used, for example, in an electrodialysis module or electrochemical cell. The membrane comprises an ion exchange polymer and inorganic particles preferably linked to the ion exchange polymer. To make a membrane, inorganic particles are mixed into an ion exchange membrane pre-cursor. A polymerization initiator or catalyst is then added and the resulting mixture is placed in a form and cured. The inorganic particles may comprise, for example, an oxidized form of graphite such as graphite oxide. The ion exchange polymer may comprise an ionic monomer, containing a quaternary ammonium group for anion exchange or a sulfonate group for cation exchange, along with a crosslinking co-monomer containing polymerizable diacrylic functionalities. The membrane is self-supporting and can be made without a supporting fabric.

Abstract: The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 (“mGluR2”). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved.

Abstract: The present disclosure is drawn to, among other things, a method of managing a memory device. In some aspects, the method includes receiving data to be stored in a storage memory, wherein the storage memory is coupled to the memory device, wherein the memory device includes a first memory type and a second memory type different from the first memory type; storing a first copy of the received data in the first memory type; storing a second copy of the received data in the second memory type; receiving indication of a power loss to the memory device; in response to receiving indication of the power loss, copying the second copy from the second memory type to the storage memory; detecting for power restoration to the memory device after the power loss; and in response to detecting power restoration to the memory device, restoring data to the first memory type by copying data from the second memory type to the first memory type.

Abstract: The present invention relates to a method of allowing users to insert themselves into movie clips, full movies, animations, music videos, commercials, sporting events and other videos. The method and computer apparatus, made up of one or more computer devices interconnected through the internet or network, allows the editing of existing videos by the creation of machine software code instruction templates to automate the editing of those videos, the method of allowing of users to record and edit their takes on those scenes and then insert their takes into the existing video using the automated template instructions that then automate the rendering of the new video composition. The present invention allows for the mass production of the new compositions to be streamed or shared as a custom video.

Abstract: The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives of formula (I) as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 (“mGluR2”) useful for the treatment of central nervous system disorders in which the mGluR2 subtype of metabotropic receptors is involved (e.g. mood disorder, schizophrenia, etc.). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for treatment of central nervous system disorders in which the mGluR2 subtype of metabotropic receptors is involved.

Abstract: An optical biometric sensor is disclosed. The optical biometric sensor includes a filter layer having a top surface and a bottom surface. The filter layer includes a light filter including a blocking material forming an array of apertures; a substrate including an electrical interconnect comprising a set of electrical conductors. The biometric sensor further includes an optical sensor including an array of sensing elements mounted to the bottom surface of the substrate, wherein sensing elements in the array of sensing elements sensors are aligned with the array of apertures and electrically connected to the electrical interconnect.

Abstract: A ventilating sill for elevating a wall partition from a floor surface in order to isolate the wall partition from moisture and humidity that can emanate from the floor surface or be present thereon. The ventilating sill includes a block having a support surface, a base surface, two opposed side surfaces and a plurality of spaced channels extending between the side surfaces forming channeled surfaces. The ventilating sill further includes a pair of slats, each slat extending from each side surface upwardly towards the wall partition at a right angle to the support surface, the slats defining a support area, and being adapted to guide the wall partition onto the support surface and at least one aperture communicating between the support area and an ambient environment for ventilating the support area and draining moisture and humidity therefrom.

Abstract: An ion exchange polymer composition is provided, which includes a primary crosslinker and a secondary crosslinker. The primary crosslinker includes a crosslinked ionic monomer including a quaternary ammonium group. A method for making the ion exchange polymer composition and materials prepared from the ion exchange polymer composition are also provided.

Abstract: An optical biometric sensor is disclosed. The optical biometric sensor includes a filter layer having a top surface and a bottom surface. The filter layer includes a light filter including a blocking material forming an array of apertures; a substrate including an electrical interconnect comprising a set of electrical conductors. The biometric sensor further includes an optical sensor including an array of sensing elements mounted to the bottom surface of the substrate, wherein sensing elements in the array of sensing elements sensors are aligned with the array of apertures and electrically connected to the electrical interconnect.

Abstract: Methods of characterizing the time-based hepatotoxicity of a test compound are provided. In some embodiments the provided methods allow prediction of the hepatotoxic potential of a test compound in a way that is improved relative to that achievable with prior art methods. In some embodiments the methods may be used to quantify the relationship between measurements or estimates of toxicity made at different, successive points in time, to provide highly meaningful tool to assess the likely in vivo hepatotoxicity of test compounds in vivo.

Abstract: An ion exchange polymer composition is provided, which includes a primary crosslinker and a secondary crosslinker. The primary crosslinker includes a crosslinked ionic monomer including a quaternary ammonium group. A method for making the ion exchange polymer composition and materials prepared from the ion exchange polymer composition are also provided.

Abstract: An ion-exchange membrane is disclosed here including ion-permeable layers impregnated with an ion-exchange material and arranged in an order from one face of the membrane to the opposite face of the membrane such that opposing layers in the supporting membrane substrate provide sufficiently identical physical properties to substantially avoid irregular expansion when in a salt solution. The ion-permeable layers including at least one non-woven layer and at least one reinforcing layer.

Abstract: A self-supported ion exchange membrane including a polymerized and crosslinked monomer, where the monomer includes: a least one ionic group, a polymerized group, and a silicate group; and a polymer chemically bonded to crosslinked monomer through the silicate group.

Abstract: The present invention relates to novel 5,6-dihydro-2H-[1,4]oxazin-3-ylamine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease and dementia associated with beta-amyloid.

Abstract: A wave power converter is presented comprising an airtight compressible bag supporting a ballast and configured to be inflated with gas. The airtight compressible bag comprises flexible walls, wherein the shape and length of the bag is determined by the equilibrium between the weight of the ballast and the pressure inside the bag. A floating body is connected to the airtight compressible bag by a tube. The converter comprises one or more airtight vessels and a power conversion means for generating power from the reciprocating flow of gas between the bag and airtight vessel. The airtight compressible bag is submerged and surrounded by water on all sides wherein the heaving and/or pitching of said floating body excites the oscillation of said ballast which squeezes and expands said airtight compressible bag driving the contained gas via the tube and power conversion means into and out of the airtight vessel.

Abstract: This specification describes an ion exchange membrane and a method of making it. The membrane may be used, for example, in an electrodialysis module or electrochemical cell. The membrane comprises an ion exchange polymer and inorganic particles preferably linked to the ion exchange polymer. To make a membrane, inorganic particles are mixed into an ion exchange membrane pre-cursor. A polymerization initiator or catalyst is then added and the resulting mixture is placed in a form and cured. The inorganic particles may comprise, for example, an oxidized form of graphite such as graphite oxide. The ion exchange polymer may comprise an ionic monomer, containing a quaternary ammonium group for anion exchange or a sulfonate group for cation exchange, along with a crosslinking co-monomer containing polymerizable diacrylic functionalities. The membrane is self-supporting and can be made without a supporting fabric.

Abstract: The present invention relates to compounds that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds of the invention can be administered to a patient in need thereof to treat or prevent psychosis including, but not limited to, schizophrenia, schizophreniform disorder and schizoaffective disorder. Compounds of the present invention include those encompassed by Formula I.

Abstract: The present invention relates to methods of treating various central nervous system disorders using novel triazolo[4,3-a]pyridine derivatives of Formula (I) wherein all radicals are as defined in the claims. The compounds according to the invention are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (“mGluR2”), which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.

Abstract: An integrated and reactive music control system designed for silencing music in an operating room during critical events. The preferred system contains a music input, a hardware interface to integrate real-time patient physiologic data, a software application to process the data, a user interface, and a music output, any portion or all of which may be hardwired or wireless. Through the user interface, medical personnel may adjust pre-set limits on physiologic parameters that indicate abnormality or risk to a particular patient. To reduce ambient noise pollution and permit communication and concentration of the surgical team, volume is reduced as a patient's condition deteriorates. Resulting in additional safety to patients in the operating room, the cessation of music may capture the attention of health care professionals who suffer from alarm desensitization. The system's integration includes an anesthesia monitor, but may extend to include a hospital data server and EMR systems.

Abstract: An ion exchange membrane and a method of making it. The membrane may be used, for example, in an electrodialysis module or electrochemical cell. The membrane comprises an ion exchange polymer and inorganic particles preferably linked to the ion exchange polymer. To make a membrane, inorganic particles are mixed into an ion exchange membrane pre-cursor. A polymerization initiator or catalyst is then added and the resulting mixture is placed in a form and cured. The inorganic particles may comprise, for example, an oxidized form of graphite such as graphite oxide. The ion exchange polymer may comprise an ionic monomer, containing a quaternary ammonium group for anion exchange or a sulfonate group for cation exchange, along with a crosslinking co-monomer containing polymerizable diacrylic functionalities. The membrane is self-supporting and can be made without a supporting fabric.