Abstract: Described herein are systems and methods for assessing a computing network's physical robustness to node and/or link failure during operation of the computing network. In one or more examples, the systems and methods can incorporate graph modeling and analysis techniques to assess the impact of node removal from a computing network and determine the impact that such removal has on the overall physical connectivity of the network. In one or more examples, a user or other entity can provide the system with a graph representation of a computing network, as well as specify the number of nodes to be removed (i.e., to simulate failure) to test the connectivity of the network. The system using these inputs can determine a worst-case scenario operating condition based on the inputs provided by the user, and can also assess the “network merit” which can represent a user-programmable definition that can represent a plurality desired types of connectivity.

Abstract: The present disclosure relates to compounds, compositions, and methods for the inducing neurodegenerative disease pathologies. In one aspect, disclosed herein is a nucleotide sequence encoding a chimeric polypeptide, comprising: a first nucleotide sequence encoding a light-induced oligomerization domain and a second nucleotide sequence encoding a neurodegenerative disease in target protein. Disclosed herein is a method of inducing a neurodegenerative disease pathology in a cell, comprising the steps: introducing into the cell an expression vector encoding a chimeric polypeptide, comprising: a first nucleotide sequence encoding a light-induced oligomerization domain and a second nucleotide sequence encoding a low complexity domain from a neurodegenerative disease target protein, wherein the first nucleotide sequence is operably linked to a promoter; expressing the chimeric polypeptide; and inducing oligomerization of the chimeric polypeptide by stimulation with blue light.

Abstract: Methods and devices for sealing a storage vessel or other apparatus are provided. A piston moves from a first position to a second position within a body to compress a sealing element, such as a metallic ring. One or more attachment elements connect the piston to the body. A removable pipe can be used for pump-out.

Abstract: Storage systems and methods of manufacturing and using the same. A storage tank is provided with an inner vessel, an outer vessel, and a support system between the vessels. The support system may comprise a repeating pattern of openings that effectively lengthens the heat path between the inner and outer vessels.

Abstract: A laundry appliance includes a cabinet. A door is coupled to the cabinet. The door is operable between an opened position and a closed position. An audio interface is disposed on the door. The audio interface includes a microphone for receiving a voice command and a speaker for projecting an audio output. A visual interface is disposed on the door. The visual interface is configured to display a message in response to at least one of the voice command and the audio output. A microcontroller is disposed on the door. The microcontroller is operably coupled to the audio interface and the visual interface. A proximity sensor is configured to communicate sensed information to the microcontroller. The microcontroller is configured to activate at least one of the audio interface and the visual interface in response to the sensed information.

Abstract: A laundry appliance includes a cabinet. A door is coupled to the cabinet. The door is operable between an opened position and a closed position. An audio interface is disposed on the door. The audio interface includes a microphone for receiving a voice command and a speaker for projecting an audio output. A visual interface is disposed on the door. The visual interface is configured to display a message in response to at least one of the voice command and the audio output. A microcontroller is disposed on the door. The microcontroller is operably coupled to the audio interface and the visual interface. A proximity sensor is configured to communicate sensed information to the microcontroller. The microcontroller is configured to activate at least one of the audio interface and the visual interface in response to the sensed information.

Abstract: An anaerobic digestion system is provided. The system includes a biomass storage container and a cover positioned over the biomass storage container, where the cover is sealed at an outer edge of the anaerobic digester. Weights may be arranged on the surface of the cover, and the sealed edges may form a water collection region. Additional systems, including thermal management, gas processing, energy storage and recovery, and sensing can also be included.

Abstract: The present disclosure relates, in general, to: (a) solid pharmaceutical dosage forms comprising acalabrutinib maleate; (b) methods of using such pharmaceutical dosage forms to treat B-cell malignancies and/or other conditions; (c) kits comprising such pharmaceutical dosage forms and, optionally, a second pharmaceutical dosage form comprising another therapeutic agent; (d) methods for the preparation of such pharmaceutical dosage forms; and (e) pharmaceutical dosage forms prepared by such methods.

Abstract: A laundry appliance includes a cabinet. A door is coupled to the cabinet. The door is operable between a closed position and an opened position. A microphone assembly is coupled to the door. The microphone assembly is configured to receive a voice command. A microcontroller is coupled to the door. The microcontroller is operably coupled to the microphone assembly and the microcontroller. A proximity sensor is coupled to the microphone assembly. The proximity sensor defines a sensor field that extends outward from the door.

Abstract: Embodiments of dispensers for dispensing wet wipes are disclosed herein. An exemplary wipes dispenser includes a container, having an opening, a cap, and a first wipe engagement member. The first wipes engagement member includes an opening therethrough. The first wipes engagement member is configured to provide sufficient force on a wipe to prevent the wipe from falling back into the container. A second wipes engagement member is also included. The second wipes engagement member located away from the first wipes engagement member. The second wipes engagement member includes a pull through portion and a grip portion. An access point is located between the first wipes engagement member and the second wipes engagement member. The access point configured to allow a user to grip a lead edge of a wipe as the wipe is threaded through the first wipes engagement member.

Abstract: Systems and methods for storing materials, such as cryogenic materials, with inner and outer vessels of a storage tank that mutually support each other. An inner vessel may also have a webbing, such as a rope lattice, that provides additional support for the storage tank.

Abstract: Exemplary embodiments of wipes dispensers are disclosed herein. An exemplary wipes dispenser having a nozzle with a wear indicator includes a container, a plurality of wipes contained within the container, a fluid for wetting the plurality of wipes, a receiving member connected to the container, and an outlet nozzle housing for holding an elastomeric outlet nozzle. The elastomeric outlet nozzle includes a wear indictor that provides a visual indication that the nozzle should be replaced.

Abstract: A laundry appliance includes a cabinet. A door is coupled to the cabinet. The door is operable between an opened position and a closed position. An audio interface is disposed on the door. The audio interface includes a microphone for receiving a voice command and a speaker for projecting an audio output. A visual interface is disposed on the door. The visual interface is configured to display a message in response to at least one of the voice command and the audio output. A microcontroller is disposed on the door. The microcontroller is operably coupled to the audio interface and the visual interface. A proximity sensor is configured to communicate sensed information to the microcontroller. The microcontroller is configured to activate at least one of the audio interface and the visual interface in response to the sensed information.

Abstract: A laundry appliance includes a cabinet. A door is coupled to the cabinet. The door is operable between an opened position and a closed position. An audio interface is disposed on the door. The audio interface includes a microphone for receiving a voice command and a speaker for projecting an audio output. A visual interface is disposed on the door. The visual interface is configured to display a message in response to at least one of the voice command and the audio output. A microcontroller is disposed on the door. The microcontroller is operably coupled to the audio interface and the visual interface. A proximity sensor is configured to communicate sensed information to the microcontroller. The microcontroller is configured to activate at least one of the audio interface and the visual interface in response to the sensed information.

Abstract: Exemplary embodiments of wipes dispensers are disclosed herein. An exemplary wipes dispenser includes a container, a plurality of wipes contained within the container, a fluid for wetting the plurality of wipes and a self-orientating outlet nozzle. The self-orientating outlet nozzle includes a moveable outlet opening. The moveable outlet opening aligns with the direction of pull of the wipe when the wipe is pulled out of the dispenser at an angle that is not substantially vertical.

Abstract: A laundry appliance includes a cabinet. A door is coupled to the cabinet. The door is operable between an opened position and a closed position. An audio interface is disposed on the door. The audio interface includes a microphone for receiving a voice command and a speaker for projecting an audio output. A visual interface is disposed on the door. The visual interface is configured to display a message in response to at least one of the voice command and the audio output. A microcontroller is disposed on the door. The microcontroller is operably coupled to the audio interface and the visual interface. A proximity sensor is configured to communicate sensed information to the microcontroller. The microcontroller is configured to activate at least one of the audio interface and the visual interface in response to the sensed information.

Abstract: A laundry appliance includes a cabinet. A door is coupled to the cabinet. The door is operable between a closed position and an opened position. A microphone assembly is coupled to the door. The microphone assembly is configured to receive a voice command. A microcontroller is coupled to the door. The microcontroller is operably coupled to the microphone assembly and the microcontroller. A proximity sensor is coupled to the microphone assembly. The proximity sensor defines a sensor field that extends outward from the door.

Abstract: Embodiments of dispensers for dispensing wet wipes are disclosed herein. An exemplary wipes dispenser includes a container, having an opening, a cap, and a first wipe engagement member. The first wipes engagement member includes an opening therethrough. The first wipes engagement member is configured to provide sufficient force on a wipe to prevent the wipe from falling back into the container. A second wipes engagement member is also included. The second wipes engagement member located away from the first wipes engagement member. The second wipes engagement member includes a pull through portion and a grip portion. An access point is located between the first wipes engagement member and the second wipes engagement member. The access point configured to allow a user to grip a lead edge of a wipe as the wipe is threaded through the first wipes engagement member.

Abstract: Exemplary embodiments of wipes dispensers are disclosed herein. An exemplary wipes dispenser having a nozzle with a wear indicator includes a container, a plurality of wipes contained within the container, a fluid for wetting the plurality of wipes, a receiving member connected to the container, and an outlet nozzle housing for holding an elastomeric outlet nozzle. The elastomeric outlet nozzle includes a wear indictor that provides a visual indication that the nozzle should be replaced.

Abstract: Processes for producing sheet metal products by machining a solid metal body with a cutting tool in a single step to continuously produce a continuous bulk form from material obtained from the solid metal body, and without performing a hot rolling operation thereon, cold rolling the continuous bulk form to produce a sheet metal product. The machining step is a large-strain machining process capable of being directly performed on an as-cast ingot or other solid body to produce a continuous intermediate product that can be directly cold rolled without any intervening hot rolling operation, and optionally without homogenization or annealing.