Abstract: One aspect can provide a direct current (DC) feedback circuit. The DC feedback circuit can include a gain path, a first feedback capacitor coupled, in parallel, to the gain path, and an input resistor coupled to an input of the gain path and the first feedback capacitor. The gain path can include an input stage with a pair of transconductance amplifiers, a gain stage with one or more amplifiers, and an output stage with at least one negative feedback amplifier.

Abstract: An implantable phototherapy device includes a power receiver element configured to receive power from an external power transmitter, a light delivery element powered by the power receiver, and configured to deliver phototherapy to a target treatment area, and a tether element is coupled to the light delivery element and the power receiver element. The tether element is configured to deliver power between the power receiver element and the light delivery element.

Abstract: Disclosed are methods of synthesis and/or purification of certain 3,7-diamino-phenothiazin-5-ium compounds (“diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (Methylene Blue), and the resulting high purity characterized by a purity greater than 98%, and very low levels of heavy metals and organic impurities Azure A, B, C and MVB. Also disclosed are methods of treatment of a tauopathy or methemoglobinemia in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the high-purity diaminophenothiazinium compound.

Abstract: Described are methods of preparing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula: wherein: R1 and R9 are independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly useful for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.

Abstract: A method of navigating visual content includes establishing an interface template including a viewport; obtaining visual content data; identifying at least one focusable element in the visual content data; presenting a first portion of visual content in the viewport on a display device, wherein the visual content is based at least partially on the visual content data; indicating a first focusable element in the viewport with a visual indicator; and responsive to a user input, scrolling the visual content in the viewport when a second focusable element of the visual content is not present in the viewport in a navigation direction of the user input.

Abstract: Systems such as electronic device systems may be provided with components such as displays and cameras mounted in an interior region of a housing. A transparent layer may be mounted to the housing and may overlap the components. The transparent layer may have glass layers and polymer layers attached to the glass layers.

Abstract: A device for inhibiting rotational motion of an article to be processed comprises a pressure plate assembly including a generally ring-shaped guide assembly. The guide assembly has and at least two guide pins extending from a first side in a transverse direction. The guide assembly further includes at least two resilient devices positioned over a respective one of the at least two guide pins and a container guide having an aperture for receiving an open end of a container moving in a first direction and for aligning the open end with a processing device. The container guide is positioned adjacent to the first side of the pressure plate assembly. At least two resilient devices are configured to be compressed in response to movement of the container guide in a first direction and are configured to decompress in response to movement of the container guide in a second, generally opposite direction.

Abstract: Outdoor power equipment includes a frame including a handle, a prime mover mounted to the frame, a transmission coupling the prime mover to a wheel, and a user interface coupled to the transmission and including a static link rigidly coupled to the handle, a forward link coupled to a forward lever and to the static link, a reverse link coupled to a reverse lever and to the static link, and a joining link coupled between the forward link and the reverse link. The user interface is actuatable between a forward configuration and a reverse configuration.

Abstract: A system, method, server, and computer readable medium for tracking goal progression. Input is received establishing one or more clients. The one or more clients are individuals receiving treatment or assistance. Each of the one or more clients are assigned to an account. Goals are established for each of the one or more clients. Data associated with each of the one or more clients is compiled as received from one or more monitoring devices. A determination is made where the goals are being met in response to the thresholds for the compiled data. Alerts are automatically communicated in response to the compiled data varying from a threshold to become significant for one of the one or more clients.

Abstract: A joist assembly system that is structured for dynamic retrieval of components, dynamic and precise positioning and location of retrieved components, assembly of the components to form a joist, and delivery of the assembled joist. The joist assembly system has a plurality of material handling systems, a plurality of welding systems, and a rigging table system. The material handling systems are structured to load and position the components such as chords and webs onto the rigging table. The rigging table in turn supports the chords or webs. Subsequently, the plurality of welding systems weld the webs to the chords to form the joist.

Abstract: A manufacturing system includes a tape advancing through the manufacturing system and a station of the manufacturing system. The tape includes a first portion having grains of an inorganic material bound by an organic binder. The station of the manufacturing system receives the first portion of the tape and prepares the tape for sintering by chemically changing the organic binder and/or removing the organic binder from the first portion of the tape, leaving the grains of the inorganic material, to form a second portion of the tape and, at least in part, prepare the tape for sintering.

Abstract: Provided is a casing washout perforating gun assembly for use in a wellbore. The casing washout perforating gun assembly, in one example, includes a carrier gun body, an uphole plurality of charges supported within the carrier gun body, and a downhole plurality of charges supported within the carrier gun body. According to this example, the uphole plurality of charges have an uphole size or uphole explosive design to perforate uphole openings having uphole opening areas within a wellbore casing, and the downhole plurality of charges have a different downhole size or different downhole explosive design to perforate downhole openings having downhole opening areas within the wellbore casing, and furthermore the downhole opening areas are at least 20 percent less than the uphole opening areas.

Abstract: A duct system for an air intake system for a vehicle, the duct system including a first duct having a first duct wall that defines a first duct opening and forms a conduit configured for conveying fluid through the first duct opening in an axial direction of the first duct opening, and a rim fixed with the first duct wall and extending from the first duct in the axial direction of the first duct opening, and disposed around the first duct opening, with a first rim portion and a second rim portion disposed along opposite sides of the first duct opening in a lateral direction of the first duct opening perpendicular to the axial direction of the first duct opening. The duct system also includes a second duct including a second duct wall that defines a second duct opening in fluid communication with the first duct opening.

Abstract: The present disclosure provides cell culture chambers for use in automated cell engineering systems, and in particular, cell culture chambers that provide increased cell yield. A cell culture chamber may include a first body forming a first portion of the cell culture chamber. A cell culture chamber may include a second body forming a second portion of the cell culture chamber, the first body and the second body configured to couple together, forming an enclosed volume, wherein a first non-porous, gas-permeable material is disposed on the first body; and wherein the first non-porous, gas-permeable material and the first body are formed together. A second non-porous, gas-permeable material may be disposed on the second body, and the second non-porous, gas-permeable material and the second body may be formed together. The cell culture chamber may further include at least one bubble trap integrally formed with the first body and/or the second body.

Abstract: Provided herein are pharmaceutical compositions for administration to a suprachoroidal space of an eye of a subject. The pharmaceutical compositions can include a recombinant adeno-associated virus (AAV) encoding a transgene. Also provided herein are methods for treating or preventing a disease in a subject by administering a therapeutically effective amount of the pharmaceutical compositions to the subject in need.

Abstract: Provided herein are pharmaceutical compositions for administration to a suprachoroidal space of an eye of a subject. The pharmaceutical compositions can include a recombinant adeno-associated virus (AAV) encoding a transgene. Also provided herein are methods for treating or preventing a disease in a subject by administering a therapeutically effective amount of the pharmaceutical compositions to the subject in need.

Abstract: A walk behind lawn mower including a frame including a handle, an engine mounted to the frame, a transmission coupling the engine to a plurality of wheels, and a user interface coupled to the transmission and including a static link rigidly coupled to the handle, a forward link coupled to a forward lever and to the static link, a reverse link coupled to a reverse lever and to the static link, and a joining link coupled between the forward link and the reverse link. The user interface is actuatable between a forward configuration and a reverse configuration using a single hand.

Abstract: Provided herein are pharmaceutical compositions for administration to a suprachoroidal space of an eye of a subject. The pharmaceutical compositions can include a recombinant adeno-associated virus (AAV) encoding a transgene. Also provided herein are methods for treating or preventing a disease in a subject by administering a therapeutically effective amount of the pharmaceutical compositions to the subject in need.

Abstract: A vehicle fender assembly includes a fender including a body having an outer surface and an inner surface opposite the outer surface. The body defines a body opening. A stiffener is mounted to the body inner surface and is located at the body opening. The stiffener includes stiffener holes sized to receive associated fasteners. A charge port assembly includes a bracket mounted to the stiffener. The bracket includes bracket holes sized to receive the associated fasteners. The bracket holes are over-sized relative to the associated fasteners to allow for positional movement of the charge port assembly on the associated fasteners relative to the body opening. The stiffener includes at least one stiffener locating feature and the bracket includes at least one bracket locating feature adapted to mate with the at least one stiffener feature to ensure proper placement of the bracket on the stiffener relative to the body opening.

Abstract: A duct system for an air intake system for a vehicle, the duct system including a first duct having a first duct wall that defines a first duct opening and forms a conduit configured for conveying fluid through the first duct opening in an axial direction of the first duct opening, and a rim fixed with the first duct wall and extending from the first duct in the axial direction of the first duct opening, and disposed around the first duct opening, with a first rim portion and a second rim portion disposed along opposite sides of the first duct opening in a lateral direction of the first duct opening perpendicular to the axial direction of the first duct opening. The duct system also includes a second duct including a second duct wall that defines a second duct opening in fluid communication with the first duct opening.