Patents by Inventor James A. Matriano
James A. Matriano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230165964Abstract: The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.Type: ApplicationFiled: November 8, 2022Publication date: June 1, 2023Inventors: Michael Sekar, Felix Theeuwes, Keith E Branham, John W Gibson, James Matriano, Whitney Moro, John Tipton, William Van Osdol, Su Il Yum
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Patent number: 11529420Abstract: The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.Type: GrantFiled: July 21, 2020Date of Patent: December 20, 2022Assignee: DURECT CORPORATIONInventors: Michael Sekar, Felix Theeuwes, Keith Edward Branham, John W Gibson, James Matriano, Whitney Moro, John Tipton, William Van Osdol, Su Il Yum
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Publication number: 20220265830Abstract: The present disclosure provides long-acting formulations and vehicles, methods of making the same and methods of using the same.Type: ApplicationFiled: July 17, 2020Publication date: August 25, 2022Applicant: DURECT CORPORATIONInventors: Susan AUTIO, Keith Edward BRANHAM, James A. FILICE, John W. GIBSON, John J. LEONARD, James MATRIANO, Whitney MORO, Michael SEKAR, Chelsea Alexandra SNYDER, Robert G. STRICKLEY, Raju SUBRAMANIAN, Felix THEEUWES, Monica TIJERINA, Jeremy C. WRIGHT, Su II YUM, Faye XU
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Publication number: 20220257619Abstract: The present disclosure provides long-acting formulations of tenofovir alafenamide, methods of making the same and methods of using the same.Type: ApplicationFiled: July 17, 2020Publication date: August 18, 2022Inventors: Susan Autio, Keith Edward Branham, James A. Filice, John W. Gibson, John J. Leonard, James Matriano, Whitney Moro, Michael Sekar, Chelsea Alexandra Snyder, Robert G. Strickley, Raju Subramanian, Felix Theeuwes, Monica Tijerina, Jeremy C. Wright, Su Il Yum, Faye Xu
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Publication number: 20210038731Abstract: The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.Type: ApplicationFiled: July 21, 2020Publication date: February 11, 2021Applicant: Durect CorporationInventors: Michael Sekar, Felix Theeuwes, Keith Edward Branham, John W. Gibson, James Matriano, Whitney Moro, John Tipton, William Van Osdol, Su Il Yum
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Patent number: 10758623Abstract: The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.Type: GrantFiled: February 2, 2018Date of Patent: September 1, 2020Assignee: DURECT CORPORATIONInventors: Michael Sekar, Felix Theeuwes, Keith E Branham, John Gibson, James Matriano, Whitney Moro, John Tipton, William Van Osdol, Su Il Yum
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Publication number: 20180256727Abstract: The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.Type: ApplicationFiled: February 2, 2018Publication date: September 13, 2018Applicant: Durect CorporationInventors: Michael Sekar, Felix Theeuwes, Keith E Branham, John Gibson, James Matriano, Whitney Moro, John Tipton, William Van Osdol, Su Il Yum
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Publication number: 20160303242Abstract: The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.Type: ApplicationFiled: December 8, 2014Publication date: October 20, 2016Applicant: Durect CorporationInventors: Michael Sekar, Felix Theeuwes, Keith E Branham, John W Gibson, James Matriano, Whitney Moro, John Tipton, William Van Osdol, Su Il Yum
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Patent number: 7798987Abstract: A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.Type: GrantFiled: March 28, 2005Date of Patent: September 21, 2010Assignee: Alza CorporationInventors: Joseph C. Trautman, Richard L. Keenan, Ahmad P. Samiee, WeiQi Lin, Michel J. N. Cormier, James A. Matriano, Peter E. Daddona
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Publication number: 20090143724Abstract: Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, and methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.Type: ApplicationFiled: February 6, 2009Publication date: June 4, 2009Applicant: Alza CorporationInventors: Michel J.N. Cormier, James A. Matriano, Peter E. Daddona, Juanita A. Johnson, Wendy A. Young
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Patent number: 7438926Abstract: This invention relates to a method for inhibiting a decrease in the transdermal flux of an agent that is being transdermally delivered or sampled over a prolonged period of time wherein the delivery or sampling involves disrupting at least the stratum corneum layer of the skin to form pathways through which the agent passes. The desired result is achieved by co-delivering or co-sampling the agent with an amount of at least one anti-healing agent wherein the amount of the anti-healing agent is effective in inhibiting a decrease in the agent transdermal flux compared to when the delivery or sampling of the agent is done under substantially identical conditions except in the absence of the anti-healing agent(s).Type: GrantFiled: September 8, 2001Date of Patent: October 21, 2008Assignee: Alza CorporationInventors: Michel Cormier, Juanita Johnson, Wei Qi Lin, James Matriano, Peter Daddona
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Publication number: 20080226687Abstract: A device and method are provided for percutaneous transdermal delivery of a biologically active agent. The coating formulation containing the biologically active agent and a vasoconstrictor is applied to the skin piercing elements using known coating techniques and then dried. The device is applied to the skin of a living animal, causing the microprojections to pierce the stratum corneum and to deliver an effective dose of the biologically active agent and vasoconstrictor to the animal.Type: ApplicationFiled: May 21, 2008Publication date: September 18, 2008Applicant: Alza CorporationInventors: Michel Cormier, James Matriano, WeiQi Lin, Wendy Young
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Patent number: 7419481Abstract: A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.Type: GrantFiled: March 28, 2005Date of Patent: September 2, 2008Assignee: ALZA CorporationInventors: Joseph C. Trautman, Richard L. Keenan, Ahmad P. Samiee, WeiQi Lin, Michel J. N. Cormier, James A. Matriano, Peter E. Daddona
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Patent number: 7131960Abstract: A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.Type: GrantFiled: October 12, 2001Date of Patent: November 7, 2006Assignee: Alza CorporationInventors: Joseph C. Trautman, Richard L. Keenan, Ahmad P. Samiee, WeiQi Lin, Michel J. N. Cormier, James A. Matriano, Peter E. Daddona
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Publication number: 20060142691Abstract: A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.Type: ApplicationFiled: March 28, 2005Publication date: June 29, 2006Inventors: Joseph Trautman, Richard Keenan, Ahmad Samiee, WeiQi Lin, Michel Cormier, James Matriano, Peter Daddona
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Publication number: 20060074377Abstract: Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, and methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.Type: ApplicationFiled: November 4, 2005Publication date: April 6, 2006Inventors: Michel Cormier, James Matriano, Peter Daddona, Juanita Johnson, Wendy Young
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Publication number: 20060051403Abstract: A transdermal delivery system having a microprojection array with one or more voids configured to allow an adhesive backing to attach to a user's skin and, hence, improve retention of the system thereto. Radial voids can be configured to enhance compliance of the array to conform more readily to non-flat areas of the skin.Type: ApplicationFiled: September 7, 2005Publication date: March 9, 2006Inventors: James Matriano, Michel Cormier, Peter Daddona
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Publication number: 20050234401Abstract: A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.Type: ApplicationFiled: March 28, 2005Publication date: October 20, 2005Inventors: Joseph Trautman, Richard Keenan, Ahmad Samiee, WeiQi Lin, Michael Cormier, James Matriano, Peter Daddona
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Publication number: 20050220854Abstract: An apparatus and method for transdermally delivering an immunologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers, the microprojection member having a biocompatible coating disposed thereon that includes the immunologically active agent. Preferably, the biocompatible coating is formed from a vaccine coating formulation.Type: ApplicationFiled: March 18, 2005Publication date: October 6, 2005Inventors: Yuh-Fun Maa, Scott Sellers, James Matriano, Asha Ramdas
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Publication number: 20050025778Abstract: Microprojection members (10) having a reservoir containing an antigenic agent and methods of using such members to vaccinate mammals (e.g., humans) are disclosed. The microprojection members are used to transdermally deliver an antigenic agent (e.g., a vaccine antigen) with substantially reduced skin reactions. This is achieved by delivering an induction amount and thereafter delivering one or more subsequent booster amounts. The induction amount is relatively larger than the booster amount. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy and convenience of use.Type: ApplicationFiled: July 1, 2004Publication date: February 3, 2005Inventors: Michel Cormier, James Matriano, Juanita Johnson, Wendy Young, Peter Daddona