Abstract: The present invention is directed to viral vectors and methods of their production and use.

Abstract: A pharmaceutical delivery device, comprising a cylindrical body formed from a plurality of concentrically arranged layers, each layer being formed from a biodegradable material and incorporating at least one active pharmaceutical agent. Optionally, the device comprises an outer layer, and inner layer and one or more intermediate layers, wherein at least one of the one or more intermediate layers is formed from a material having a greater rate of degradation that the inner and outer layers such that the inner and outer layers separate in use.

Abstract: The present disclosure provides methods for treating, preventing, or inhibiting diseases in patients having one or more mutations in complement factor H (CFH), complement component 3 (C3), and complement factor B (CFB) by administering to the patients a recombinant adeno-associated virus (rAAV) vector encoding a CFH polypeptide or biologically active fragment and/or variant thereof.

Abstract: The present disclosure provides methods for treating, preventing, or inhibiting diseases in patients having one or more mutations in complement factor H (CFH), complement component 3 (C3), and complement factor B (CFB). Also provided are combination therapies comprising a CFH protein and a VEGF antagonist for treating neovascularization-associated ocular diseases.

Abstract: The present disclosure provides methods for treating, preventing, or inhibiting diseases in patients having one or more CFI mutations.

Abstract: A lateral flow immunoassay device includes a porous test strip, a sampling channel having an inlet at a first end to receive a biomarker and an outlet at a second end, opposite the first end, the outlet communicating with the test strip. The sampling channel has an air vent opening at or adjacent the second end thereof, and a diluent reservoir having an outlet communicating with the test strip. The outlet of the sampling channel and the outlet of the diluent reservoir are sealed by a common removable seal to prevent communication between the sampling channel and the test strip, and the diluent reservoir and the test strip, until the seal is removed.

Abstract: A handle assembly is provided for an outlet valve of a tank car wherein the outlet valve has a valve stem rotatable about an axis and is operative to open and close the outlet valve. The handle assembly includes a valve handle for manually opening the outlet valve, a rotatable shaft coupled to the handle, and a coupling coupled to the outlet valve and selectively coupleable to the shaft. A valve rotation control structure includes a first movement control component on one of the coupling and the shaft. The valve rotation control structure is configured to permit the coupling or shaft to move parallel to the axis of the valve stem between a first locked position and a second rotatable position and to rotate about the axis of the valve stem between a first valve closed position and a second valve open position at the second rotatable position.

Abstract: An external transmitter apparatus for a transcutaneous energy transfer (TET) system for supplying power for use in energising an implantable medical device is disclosed, the apparatus comprising an external transmitter apparatus comprising a plurality of transmitter coils for delivering power transcutaneously to one of a plurality of receiver coils of an implantable receiver apparatus of the TET system when located in proximity thereto. The external transmitter apparatus is provided with power by a pulsed power supply. The coils of the external transmitter apparatus and the implantable receiver apparatus may be printed on flexible substrates. Also disclosed are methods of operating such a system, an external transmitter apparatus for use in such a system, an external transmitter apparatus and an implantable receiver apparatus including flexible coils.

Abstract: The present disclosure provides compositions and methods for treating, preventing, or inhibiting diseases of the eye. In one aspect, the disclosure provides recombinant CF1 adeno-associated virus (rAAV) vectors comprising a complement system gene.

Abstract: The present disclosure provides compositions and methods for treating, preventing, or inhibiting diseases of the eye. In one aspect, the disclosure provides recombinant CFH FHL-1 adeno-associated virus (rAAV) vectors comprising a complement system gene.

Abstract: The present disclosure provides compositions and methods for treating, preventing, or inhibiting diseases of the eye. In one aspect, the disclosure provides HTRA1 ASO agents and methods of using the same.

Abstract: The present disclosure provides compositions and methods for treating, preventing, or inhibiting diseases of the eye. In one aspect, the disclosure provides compositions comprising HTRA1 guide RNA sequences and uses thereof.

Abstract: A handle assembly is provided for an outlet valve of a tank car wherein the outlet valve has a valve stem rotatable about an axis and is operative to open and close the outlet valve. The handle assembly includes a valve handle for manually opening the outlet valve, a rotatable shaft coupled to the handle, and a coupling coupled to the outlet valve and selectively coupleable to the shaft. A valve rotation control structure includes a first movement control component on one of the coupling and the shaft. The valve rotation control structure is configured to permit the coupling or shaft to move parallel to the axis of the valve stem between a first locked position and a second rotatable position and to rotate about the axis of the valve stem between a first valve closed position and a second valve open position at the second rotatable position.

Abstract: A handle assembly is provided for an outlet valve of a tank car wherein the outlet valve has a valve stem rotatable about an axis and is operative to open and close the outlet valve. The handle assembly includes a valve handle for manually opening the outlet valve, a rotatable shaft coupled to the handle, and a coupling coupled to the outlet valve and selectively coupleable to the shaft. A valve rotation control structure includes a first movement control component on one of the coupling and the shaft. The valve rotation control structure is configured to permit the coupling or shaft to move parallel to the axis of the valve stem between a first locked position and a second rotatable position and to rotate about the axis of the valve stem between a first valve closed position and a second valve open position at the second rotatable position.

Abstract: The present disclosure provides compositions and methods for treating, preventing, or inhibiting diseases of the eye. In one aspect, the disclosure provides HTRA1 RNAi agents and methods of using the same.

Abstract: A system for charging a battery from various three phase or single phase grid supply voltages includes a full wave bridge rectifier for receiving the AC supply voltage, two DC to DC converters for receiving unregulated DC output voltage from the rectifier, a first switch connected to a first input line of a first one of the two converters and a second switch connected to a first input line of a second one of the two converters, wherein each of the switches is set to a first position when the supply voltage is at a lower one of the varying voltage levels and to a second position when the supply voltage is at a higher one of the varying voltage levels.