Abstract: A fiber optic sensing (FOS) system and method. The system may include one or more interrogator units and a proximal wavelength division multiplexer (WDM) and a distal WDM optically connectable to the one or more interrogator units, an upgoing transmission fiber, a down-going transmission fiber, and one or more downhole sensing fibers. The method may include transmitting one or more light pulses from an interrogator unit, multiplexing the one or more light pulses from the interrogator unit with a proximal WDM into an upgoing transmission fiber and a down-going transmission fiber, and receiving the one or more light pulses with a distal WDM. The method may further include multiplexing the one or more light pulses from the upgoing transmission fiber and the down-going transmission fiber into one or more downhole sensing fibers and receiving backscatter light from at least one of the one or more downhole sensing fibers.

Abstract: Aspects of the present disclosure provide technical solutions embodied in a predictive profiling platform. In example embodiments, the predictive profiling platform is configured to generate multi-dimensional system profiles and predictions thereof, provide shared visibility of system profiles between systems that are mapped together based on relationships between respective users, and enable improved cross-system functionality and operations.

Abstract: The present invention describes, in certain embodiments, a composition for detecting a tau protein comprising a modified detector molecule having two ends, a first end capable of binding the tau protein and a second end comprising a single-stranded DNA template, wherein the template is capable of being replicated by an RNA polymerase.

Abstract: The present invention provides methods and, accordingly, in vitro systems for generating stable and soluble oligomers of amyloid proteins, under physiological pH and temperature; and hence, a system for identifying and validating drugs that have the potential to prevent formation of soluble oligomers of amyloid proteins, to disaggregate soluble oligomers of amyloid proteins already formed and possibly disaggregate downstream larger insoluble aggregates of amyloid proteins.

Abstract: In some embodiments, an electromagnetic motor/generator may include a frame, an axle, first and second magnetic sections coupled to the axle, a center magnet section, and a solenoid coupled to the frame and the center magnet section, the solenoid adapted to move the center magnetic section to cause movement of the first and second magnetic sections, and thereby cause rotation of the axle.

Abstract: Described herein are compositions and methods for identifying cellular factors involved in protein agglomeration. One such factor is a nucleic acid component. Another factor is a cellular binding factor. The nucleic acid components, and methods of using them, to interact with agglomeration proteins are also disclosed herein. The nucleic acid compositions herein comprise one or more DNA or RNA molecules having affinity for at least one agglomeration protein. The nucleic acid component is a naturally or non-naturally occurring molecule with twenty or more ribonucleotide bases. For RNA, at least one nucleotide sequence portion of this RNA molecule has affinity to at least one consensus sequence present in the agglomeration RNA-binding protein. Methods disclosed herein are directed towards detecting the presence of one or more agglomeration proteins in a sample matrix using the amplibody compositions described herein.

Abstract: The present invention describes, in certain embodiments, a composition for detecting a tau protein comprising a modified detector molecule having two ends, a first end capable of binding the tau protein and a second end comprising a single-stranded DNA template, wherein the template is capable of being replicated by an RNA polymerase.

Abstract: The present invention provides nanophotovoltaic devices having sizes in a range of about 50 nm to about 5 microns, and method of their fabrication. In some embodiments, the nanophotovoltaic device includes a semiconductor core, e.g., formed of silicon, sandwiched between two metallic layers, one of which forms a Schottky barrier junction with the semiconductor core and the other forms an ohmic contact therewith. In other embodiment, the nanophotovoltaic device includes a semiconductor core comprising a p-n junction that is sandwiched between two metallic layers forming ohmic contacts with the core.

Abstract: The present invention provides means and methods for producing surface-activated semiconductor nanoparticles suitable for in vitro and in vivo applications that can fluoresce in response to light excitation. Semiconductor nanostructures can be produced by generating a porous layer in semiconductor substrate comprising a network of nanostructures. Prior or subsequent to cleavage from the substrate, the nanostructures can be activated by an activation means such as exposing their surfaces to a plasma, oxidation or ion implantation. In some embodiments, the surface activation renders the nanostructures more hydrophilic, thereby facilitating functionalization of the nanoparticles for either in vitro or in vivo use.

Abstract: In some embodiments, an electromagnetic motor/generator may include one or more of the following features: (a) a frame, (b) a magnetic section having an upper magnet, a lower magnet, and a center magnet, coupled to the frame, and (c) at least one solenoid coupled to the frame and the center magnet.

Abstract: The selection console of the present invention affords a plurality of finger-actuated push buttons which move a short distance to actuate the item-selecting mechanism of a vending machine. The console utilizes a single solenoid to unlock the selector mechanism in response to the energization of the coin accumulator and price mechanism and actuation of a selection price switch. Further, the machine permits the items in the vending machine to be priced at different values without the necessity of separate mechanisms, except for a switch to be actuated by each price bar. Once a price has been selected, the locking mechanism of the console of this invention prohibits one from changing to a different item.