Patents by Inventor James A. Munro

James A. Munro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9938324
    Abstract: A modified HIV gp120 protein labeled with a fluorophore has been used herein in single-molecule imaging techniques to demonstrate the conformation states of HIV-1 Env. The introduction of small organic fluorophores at selected positions within HIV-1 envelope protein gp120 that do not affect infectivity permits the detection of changes in inter-dye distances as a measure of conformational changes. Implementation of the smFRET-based technologies disclosed herein enable conformational screening for molecules that block, induce or trap HIV-1 Env in specific conformational states. Methods for identifying anti-HIV drugs in a smFRET-based screening, and various reagents useful for implementation of such methods, are provided.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: April 10, 2018
    Assignees: CORNELL UNIVERSITY, YALE UNIVERSITY
    Inventors: Scott C. Blanchard, Walther Mothes, James Munro
  • Patent number: 9501822
    Abstract: Automatically selecting time traces from a fluorescence experiment, in one aspect, may include capturing results of the fluorescence experiment in a moving image; localizing sources of fluorescence in the moving image; producing time traces of each fluorescent source by monitoring fluorescence intensity of said localized sources in the moving image over time; removing unuseful time traces from said produced time traces; and selecting useful time traces from said produced time traces based on one or more defined criteria. FRET traces from selected time traces may be further calculated and analyzed. A unified computer-implemented platform in one aspect may include tools to locate single molecules, extract traces, classify smFRET traces according to adjustable parameters, and quantify the kinetic parameters of FRET transitions using analytical procedures such as Hidden Markov Modeling (HMM) procedures.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: November 22, 2016
    Assignee: CORNELL UNIVERSITY
    Inventors: Scott Blanchard, Daniel Terry, James Munro, Peter Geggier
  • Publication number: 20150166611
    Abstract: Single-molecule imaging techniques have been applied herein and have demonstrated the conformation states of HIV-1 Env. The introduction of small organic fluorophores at selected positions within HIV-1 Env that do not affect infectivity permits the detection of changes in inter-dye distances as a measure of conformational changes. Implementation of the smFRET-based technologies disclosed herein enable conformational screening for molecules that block, induce or trap HIV-1 Env in specific conformational states. Methods for identifying anti-HIV drugs in a smFRET-based screening, and various reagents useful for implementation of such methods, are provided.
    Type: Application
    Filed: May 22, 2013
    Publication date: June 18, 2015
    Applicants: YALE UNIVERSITY, Cornell University
    Inventors: Scott C. Blanchard, Walther Mothes, James Munro
  • Publication number: 20130308842
    Abstract: Automatically selecting time traces from a fluorescence experiment, in one aspect, may include capturing results of the fluorescence experiment in a moving image; localizing sources of fluorescence in the moving image; producing time traces of each fluorescent source by monitoring fluorescence intensity of said localized sources in the moving image over time; removing unuseful time traces from said produced time traces; and selecting useful time traces from said produced time traces based on one or more defined criteria. FRET traces from selected time traces may be further calculated and analyzed. A unified computer-implemented platform in one aspect may include tools to locate single molecules, extract traces, classify smFRET traces according to adjustable parameters, and quantify the kinetic parameters of FRET transitions using analytical procedures such as Hidden Markov Modeling (HMM) procedures.
    Type: Application
    Filed: January 27, 2012
    Publication date: November 21, 2013
    Applicant: CORNELL UNIVERSITY
    Inventors: Scott Blanchard, Daniel Terry, James Munro, Peter Geggier
  • Patent number: 7961332
    Abstract: A method and system for performing two-dimensional laser Doppler vibrometry (LDV) are disclosed. A high speed fiber optic heterodyne imaging vibrometer can be used for the imaging of high speed surface deformation and/or vibration. Images provided by the high speed fiber optic heterodyne imaging vibrometer can be representative of movement, e.g., displacement or vibration, of the surface being imaged.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: June 14, 2011
    Assignee: MetroLaser, Inc.
    Inventors: James Munro Kilpatrick, Vladimir B. Markov
  • Publication number: 20100038388
    Abstract: An adjustable clothing hanger including a pair of side members (104,106) selectively adjustable relative to a hanger body (102) and in moveable relationship with upper and lower cross bars (108, 110). The hanger may also include a lockably rotatable hook (100).
    Type: Application
    Filed: July 11, 2007
    Publication date: February 18, 2010
    Inventor: Peter James Munro
  • Patent number: 7495170
    Abstract: This invention pertains to an adjustable cover for an electrical outlet box. The cover is configured having a generally planar mounting plate with a collar surrounding an opening through this mounting plate. An extension sleeve moves within this opening and adjacent the collar. At least one fastener is located adjacent the opening and is movable between a locked position and an unlocked position. The fastener operates a locking device that engages and bias against the extension sleeve when the fastener is in the locked position and which disengage and cease biasing the extension sleeve when the fastener is in the unlocked position.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: February 24, 2009
    Assignee: Thomas & Betts International, Inc.
    Inventors: Cong Thanh Dinh, Andrew Christopher Cole, James Munro Sanders
  • Publication number: 20090046296
    Abstract: A method and system for performing two-dimensional laser Doppler vibrometry (LDV) are disclosed. A high speed fiber optic heterodyne imaging vibrometer can be used for the imaging of high speed surface deformation and/or vibration. Images provided by the high speed fiber optic heterodyne imaging vibrometer can be representative of movement, e.g., displacement or vibration, of the surface being imaged.
    Type: Application
    Filed: June 6, 2008
    Publication date: February 19, 2009
    Inventors: James Munro Kilpatrick, Vladimir B. Markov
  • Publication number: 20080050013
    Abstract: Methods and systems for three-dimensional imaging include sampling one or more emissions which are reflected back from a target scene with one or more micro-channel plates. The one or more sampled emissions are processed in one or more frames. Within each frame a phase is extracted and a distance to the target scene and amplitude is determined on a pixel-by-pixel basis. A three dimensional image of the target scene is generated and provided based on the extracted phase and the determined distance and amplitude for the one or more frames.
    Type: Application
    Filed: August 22, 2007
    Publication date: February 28, 2008
    Inventor: James MUNRO
  • Publication number: 20070290584
    Abstract: This invention pertains to an adjustable cover for an electrical outlet box. The cover is configured having a generally planar mounting plate with a collar surrounding an opening through this mounting plate. An extension sleeve moves within this opening and adjacent the collar. At least one fastener is located adjacent the opening and is movable between a locked position and an unlocked position. The fastener operates a locking device that engages and bias against the extension sleeve when the fastener is in the locked position and which disengage and cease biasing the extension sleeve when the fastener is in the unlocked position.
    Type: Application
    Filed: March 13, 2007
    Publication date: December 20, 2007
    Inventors: Cong Thanh Dinh, Andrew Christopher Cole, James Munro Sanders
  • Publication number: 20070002452
    Abstract: A collimating sheet, for use with a backlit display and the like, that includes a substrate, a plurality of microlenses on the output side of the substrate, a specularly reflective layer on the side of the substrate opposite the microlenses, and a plurality of apertures in the reflective layer in direct correspondence to the microlenses of the lens array. The specularly reflective layer can be relatively thinner than a diffuse reflective layer, which allows light to pass through the more readily. One or more layers of dielectric can be placed on top of one or more reflective material layers to further improves overall reflectivity. Apertures are preferably made in the light-absorptive and reflective layers with a laser ablation process wherein laser light illuminates the output side of the film. The laser light is brought to a focus by the lenslets of the lens array onto the light-absorptive layer, which then ablates a hole or aperture into the light-absorptive and reflective layer.
    Type: Application
    Filed: June 29, 2006
    Publication date: January 4, 2007
    Inventor: James Munro
  • Publication number: 20070002453
    Abstract: A collimating sheet, for use with a backlit display and the like, that includes a substrate, a plurality of microlenses on the output side of the substrate, a specularly reflective layer on the side of the substrate opposite the microlenses, and a plurality of apertures in the reflective layer in direct correspondence to the microlenses of the lens array. The specularly reflective layer can be relatively thinner than a diffuse reflective layer, which allows light to pass through the more readily. One or more layers of dielectric can be placed on top of one or more reflective material layers to further improves overall reflectivity. Apertures are preferably made in the light-absorptive and reflective layers with a laser ablation process wherein laser light illuminates the output side of the film. The laser light is brought to a focus by the lenslets of the lens array onto the light-absorptive layer, which then ablates a hole or aperture into the light-absorptive and reflective layer.
    Type: Application
    Filed: June 29, 2006
    Publication date: January 4, 2007
    Inventor: James Munro
  • Publication number: 20060061861
    Abstract: A rear-projection screen and a method for forming same are provided. The screen can include a substrate including a first side and a second side, apertures disposed on the first side of the substrate, and an opaque layer disposed on the second side of the substrate. In a particular embodiment, the opaque layer includes a plurality of apertures therethrough. A surface relief diffuser can be provided in the substrate at the plurality of apertures. A bulk diffuser can be provided at the plurality of apertures to diffuse the projected image. A cover can be attached to the opaque layer, for example, with an adhesive. An overlayer can be provided on the opaque layer for providing deep apertures that can be filled with bulk diffuser to further diffuse the projected image. The overlayer disposed on the opaque layer can include a light-absorbing material in and/or on the overlayer.
    Type: Application
    Filed: September 23, 2004
    Publication date: March 23, 2006
    Applicant: Reflexite Corporation
    Inventors: James Munro, Patrick Mullen
  • Publication number: 20020089549
    Abstract: A method, apparatus, and system in which a viewer displays and manipulates a bitmap image within a window in a network system. The bitmap image has a hierarchal system of folders associated with the bitmap image.
    Type: Application
    Filed: January 9, 2001
    Publication date: July 11, 2002
    Inventors: James A. Munro, Haishan Wang
  • Publication number: 20020033837
    Abstract: A method, apparatus, and system in which a multiple-image viewer concurrently displays and manipulates multiple images within a single window in a network system. One or more of the display images are a raster graphic file. Each of the display images has a separate data file.
    Type: Application
    Filed: January 9, 2001
    Publication date: March 21, 2002
    Inventor: James A. Munro
  • Patent number: 6113744
    Abstract: A water distillation apparatus includes a degasification chamber having a top and a bottom. A liquid inlet is positioned adjacent to the bottom. A gas outlet is positioned adjacent to the top. A liquid outlet is positioned intermediate the top and the bottom. A float/valve assembly is provided for controlling the level of liquid within the chamber. A boiling chamber is provided having a top and a bottom. A liquid inlet is positioned intermediate the top and the bottom connected by a first transfer conduit to the liquid outlet of the degasification chamber. A steam outlet is positioned adjacent the top. A heating element is disposed within the boiling chamber whereby liquids within the boiling chamber are heated to the boiling point with the resulting steam passing out through the steam outlet. A condensation chamber is provided having a steam inlet and a liquid outlet. The steam inlet is connected by a second transfer conduit to the steam outlet of the boiling chamber.
    Type: Grant
    Filed: July 13, 1998
    Date of Patent: September 5, 2000
    Inventor: James Munro
  • Patent number: 5341522
    Abstract: A water conservation device for use in toilet tanks which have a valve movable between an open and a closed position. The valve is connected to a flush linkage which draws the valve to the open position upon activation of a flushing lever. The water conservation device consists of an elongate body having a first end and a second end. The first end of the elongate body is indirectly linked to the valve. The second end of the elongate body is indirectly suspended within the toilet tank, such that the elongate body is disposed at an angle to the valve. As the elongate body pivots, the weight of the elongate body pulls the valve into the closed position.
    Type: Grant
    Filed: May 28, 1993
    Date of Patent: August 30, 1994
    Assignee: The Enviro Shop Corp.
    Inventor: James Munro
  • Patent number: 4420177
    Abstract: The invention relates to knotters for tying knots and has particular, but not exclusive, application to agricultural balers. In known baler knotters, twine for tying the bales is cut by a fixed or movable knife in such a way that substantially the same portion of the knife edge is used for cutting with the result that early blunting occurs which can give rise to only partially cut twine which adversely affects the knotter. In accordance with the invention a knotter (24) comprises a twine holder (63) operable to hold, during a knot-tying operation, a primary and a secondary portion (20,43) of twine in which the knot is to be tied, and rotary knife means (130) operable to cut at least one of said twine portions at a predetermined point in the operational cycle of the knotter and as said at least one twine portion is held by the twine holder.
    Type: Grant
    Filed: June 20, 1980
    Date of Patent: December 13, 1983
    Assignee: Sperry Corporation
    Inventors: James A. Munro, Marc G. Vansteelant
  • Patent number: 4370924
    Abstract: A baler for baling crop material, comprising a feed mechanism including two relatively slidable elongate support members (6, 10) carrying a plurality of depending feed fingers (7, 9, 18), a feed area (1) within which the feed fingers are movable, a bale chamber communicating with one end of the feed area (1) and a bale plunger (25) reciprocable within the bale chamber, the two support members (6, 10) being constrained to move in continuous loop-like paths during a lower run of which one of the support members (6) leads and the other (10) trails as the feed fingers (7, 9, 18) engage the crop material within the feed area (1) and transfer the crop material towards, respectively into the bale chamber, at least one of the feed fingers (18) being mounted on the trailing support member (10) to ensure that crop material disposed at the other end of the feed area (1) is moved towards the bale chamber, thereby preventing an accumulation of crop material at the other end of the feed area.
    Type: Grant
    Filed: July 28, 1980
    Date of Patent: February 1, 1983
    Assignee: Sperry Corporation
    Inventor: James A. Munro
  • Patent number: D852884
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: July 2, 2019
    Assignee: AMERICAN ASSOCIATION OF GYNECOLOGICAL LAPAROSCOPISTS, INC.
    Inventors: Malcolm Munro, James Messerschmidt, Ted Anderson, Joseph Hudgens