Patents by Inventor James A. Nieman

James A. Nieman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12186309
    Abstract: The present disclosure provides compounds and methods for inhibiting a virus infection, such as a Baltimore Group IV RNA virus infection. Aspects of the present disclosure also include methods of treating a Baltimore Group IV RNA virus infection in a subject. The present disclosure also provides pharmaceutical compositions related to the same.
    Type: Grant
    Filed: September 22, 2022
    Date of Patent: January 7, 2025
    Assignee: The Governors of the University of Alberta
    Inventors: James A. Nieman, M. Joanne Lemieux, D. Lorne Tyrrell, Mostofa Hena, Appan Srinivas Kandadai, Alexandr Belovodskiy, Michael A. Joyce, Elena Arutyunova
  • Publication number: 20240376059
    Abstract: The present disclosure provides compounds that are amylin receptor antagonist compounds, compositions that include the subject compounds, methods for preparing and using the amylin receptor antagonists, and compositions containing the amylin receptor antagonists for treating, preventing, or ameliorating Alzheimer's disease. Aspects of the present disclosure include a method of inhibiting activity of an amylin receptor by administering to a subject in need thereof a therapeutically effective amount of an amylin receptor antagonist.
    Type: Application
    Filed: February 16, 2024
    Publication date: November 14, 2024
    Inventors: James A. Nieman, Jack Jhamandas, Bing Bai, Alexandr Belovodskiy, Wen Fu, Mostofa Hena, Michael Houghton, Appan Srinivas Kandadai, Ryoichi Kimura, Kamlesh Kumar Sahu, D. Lorne Tyrell
  • Patent number: 11939302
    Abstract: The present disclosure provides compounds that are amylin receptor antagonist compounds, compositions that include the subject compounds, methods for preparing and using the amylin receptor antagonists, and compositions containing the amylin receptor antagonists for treating, preventing, or ameliorating Alzheimer's disease. Aspects of the present disclosure include a method of inhibiting activity of an amylin receptor by administering to a subject in need thereof a therapeutically effective amount of an amylin receptor antagonist.
    Type: Grant
    Filed: October 19, 2021
    Date of Patent: March 26, 2024
    Assignee: The Governors of the University of Alberta
    Inventors: James A. Nieman, Jack Jhamandas, Bing Bai, Alexandr Belovodskiy, Wen Fu, Mostofa Hena, Michael Houghton, Appan Srinivas Kandadai, Ryoichi Kimura, Kamlesh Kumar Sahu, D. Lorne Tyrrell
  • Publication number: 20230399296
    Abstract: The present disclosure provides compounds with increased metabolic stability for inhibiting a virus infection, such as a Baltimore Group IV RNA virus infection, such as rhinovirus, coxsackievirus, norovirus and coronavirus. Aspects of the present disclosure also include methods of treating the virus infection in a subject with compounds with increased metabolic stability.
    Type: Application
    Filed: June 2, 2023
    Publication date: December 14, 2023
    Inventors: James A. Nieman, M. Joanne Lemieux, Elena Arutyunova, Michael A. Joyce, D. Lorne Tyrrell, Holly Saffran, Bing Bai, Mostofa Hena, Appan Srinivas Kandadai
  • Publication number: 20230108588
    Abstract: The present disclosure provides compounds and methods for inhibiting a virus infection, such as a Baltimore Group IV RNA virus infection. Aspects of the present disclosure also include methods of treating a Baltimore Group IV RNA virus infection in a subject. The present disclosure also provides pharmaceutical compositions related to the same.
    Type: Application
    Filed: September 22, 2022
    Publication date: April 6, 2023
    Inventors: James A. Nieman, M. Joanne Lemieux, D. Lorne Tyrrell, Mostofa Hena, Appan Srinivas Kandadai, Alexandr Belovodskiy, Michael A. Joyce, Elena Arutyunova
  • Publication number: 20220226335
    Abstract: The present disclosure provides non-peptidic heterocycle-containing amylin receptor antagonist compounds, compositions that include the subject compounds, methods for preparing and using the amylin receptor antagonists, and compositions containing the amylin receptor antagonists for treating, preventing, or ameliorating Alzheimer's disease. Aspects of the present disclosure include a method of inhibiting activity of an amylin receptor by administering to a subject in need thereof a therapeutically effective amount of an amylin receptor antagonist.
    Type: Application
    Filed: April 23, 2020
    Publication date: July 21, 2022
    Inventors: Jack Jhamandas, Wen Fu, Ryoichi Kimura, D. Lorne Tyrrell, Ana Clementin, Kamlesh Sahu, Alexandr Belovodskiy, Mostofa Hena, Bing Bai, Appan Srinivas Kandadai, James A. Nieman, Michael Houghton
  • Publication number: 20220204476
    Abstract: The present disclosure provides compounds and methods for inhibiting a virus infection, such as a Baltimore Group IV RNA virus infection, such as rhinovirus, coxsackievirus, norovirus and coronavirus. Aspects of the present disclosure also include methods of treating a virus infection in a subject.
    Type: Application
    Filed: December 20, 2021
    Publication date: June 30, 2022
    Inventors: James A. Nieman, M. Joanne Lemieux, D. Lorne Tyrrell, Bing Bai, Alexandr Belovodskiy, Mostofa Hena, Appan Srinivas Kandadai, Michael A. Joyce
  • Publication number: 20220119356
    Abstract: The present disclosure provides compounds that are amylin receptor antagonist compounds, compositions that include the subject compounds, methods for preparing and using the amylin receptor antagonists, and compositions containing the amylin receptor antagonists for treating, preventing, or ameliorating Alzheimer's disease. Aspects of the present disclosure include a method of inhibiting activity of an amylin receptor by administering to a subject in need thereof a therapeutically effective amount of an amylin receptor antagonist.
    Type: Application
    Filed: October 19, 2021
    Publication date: April 21, 2022
    Inventors: James A. Nieman, Jack Jhamandas, Bing Bai, Alexandr Belovodskiy, Wen Fu, Mostofa Hena, Michael Houghton, Appan Srinivas Kandadai, Ryoichi Kimura, Kamlesh Kumar Sahu, D. Lorne Tyrrell
  • Patent number: 10533021
    Abstract: This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: January 14, 2020
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Stephen J. Baker, Vincent S. Hernandez, Rashmi Sharma, James A. Nieman, Tsutomu Akama, Yong-Kang Zhang, Jacob J. Plattner, Michael Richard Kevin Alley, Rajeshwar Singh, Fernando Rock
  • Publication number: 20180016285
    Abstract: This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 18, 2018
    Inventors: Stephen J. Baker, Vincent S. Hernandez, Rashmi Sharma, James A. Nieman, Tsutomu Akama, Yong-Kang Zhang, Jacob J. Plattner, Michael Richard Kevin Alley, Rajeshwar Singh, Fernando Rock
  • Patent number: 9796735
    Abstract: The compounds are of the class of 3,7 substituted benzoxaboroles, useful for killing and/or inhibiting the growth of microorganisms.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: October 24, 2017
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Stephen J. Baker, Vincent S. Hernandez, Rashmi Sharma, James A. Nieman, Tsutomu Akama, Yong-Kang Zhang, Jacob J. Plattner, Michael Richard Kevin Alley, Rajeshwar Singh, Fernando Rock
  • Publication number: 20160287563
    Abstract: Novel cysteine prodrugs and their use in the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of the Central Nervous System (CNS), including but not limited to schizophrenia, drug craving, drug addiction, bipolar disorder, anxiety, depression, Parkinson's disease, Alzheimer's disease, cognitive dysfunction, multiple sclerosis, Amyotrophic lateral sclerosis (ALS), ischemic stroke, HIV dementia, and Huntington's disease.
    Type: Application
    Filed: June 6, 2016
    Publication date: October 6, 2016
    Applicant: Promentis Pharmaceuticals, Inc.
    Inventors: Daniel Lawton, Michael Neary, James A. Nieman
  • Patent number: 9457014
    Abstract: Novel cysteine prodrugs and their use in the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of the Central Nervous System (CNS), including but not limited to schizophrenia, drug craving, drug addiction, bipolar disorder, anxiety, depression, Parkinson's disease, Alzheimer's disease, cognitive dysfunction, multiple sclerosis, Amyotrophic lateral sclerosis (ALS), ischemic stroke, HIV dementia, and Huntington's disease.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: October 4, 2016
    Assignee: Promentis Pharmaceuticals, Inc.
    Inventors: Daniel Lawton, Michael Neary, James A. Nieman
  • Publication number: 20160081987
    Abstract: Novel cysteine prodrugs and their use in the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of the Central Nervous System (CNS), including but not limited to schizophrenia, drug craving, drug addiction, bipolar disorder, anxiety, depression, Parkinson's disease, Alzheimer's disease, cognitive dysfunction, multiple sclerosis, Amyotrophic lateral sclerosis (ALS), ischemic stroke, HIV dementia, and Huntington's disease.
    Type: Application
    Filed: July 30, 2012
    Publication date: March 24, 2016
    Applicant: PROMENTIS PHARMACEUTICALS, INC.
    Inventors: Daniel Lawton, Michael Neary, James A. Nieman
  • Publication number: 20150133402
    Abstract: This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
    Type: Application
    Filed: November 7, 2014
    Publication date: May 14, 2015
    Inventors: STEPHEN J. BAKER, VINCENT S. HERNANDEZ, RASHMI SHARMA, JAMES A. NIEMAN, TSUTOMU AKAMA, YONG-KANG ZHANG, JACOB J. PLATTNER, MICHAEL RICHARD KEVIN ALLEY, RAJESHWAR SINGH, FERNANDO ROCK
  • Patent number: 8895534
    Abstract: Novel monosubstituted and disubstutituted oxaboroles and pharmaceutical compositions containing such oxaboroles are provided, which are useful for treating bacterial infections, as well as combinations of these oxaboroles with at least one additional therapeutically effective agent.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: November 25, 2014
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Stephen J. Baker, Vincent S. Hernandez, Rashmi Sharma, James A. Nieman, Tsutomu Akama, Yong-Kang Zhang, Jacob J. Plattner, Michael Richard Kevin Alley, Rajeshwar Singh, Fernando Rock
  • Publication number: 20140011768
    Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
    Type: Application
    Filed: June 11, 2013
    Publication date: January 9, 2014
    Inventors: Tsutomu Akama, Yong-Kang Zhang, Charles Z. Ding, Jacob J. Plattner, Kirk R. Maples, Yvonne Freund, Virginia Sanders, Yi Xia, Stephen J. Baker, James A. Nieman, Xiaosong Lu, Marcelo Sales, Rashmi Sharma, Rajeshwar Singh, Robert Jacobs, Daitao Chen, Michael Richard Kevin Alley
  • Patent number: 8461135
    Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: June 11, 2013
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Tsutomu Akama, Yong-Kang Zhang, Charles Z. Ding, Jacob J. Plattner, Kirk R. Maples, Yvonne Freund, Virginia Sanders, Yi Xia, Stephen J. Baker, James A. Nieman, Xiaosong Lu, Marcelo Sales, Rashmi Sharma, Rajeshwar Singh, Robert T. Jacobs, Daitao Chen, Michael Richard Kevin Alley
  • Patent number: 8461134
    Abstract: This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: June 11, 2013
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Vincent S. Hernandez, Xianfeng Li, Suoming Zhang, Tsutomu Akama, Yanchen Zhang, Yang Liu, Jacob J. Plattner, Michael Richard Kevin Alley, Yasheen Zhou, James A. Nieman
  • Publication number: 20120214765
    Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
    Type: Application
    Filed: September 19, 2011
    Publication date: August 23, 2012
    Applicant: Anacor Pharmaceuticals, Inc.
    Inventors: Tsutomu Akama, Yong-Kang Zhang, Charles Z. Ding, Jacob J. Plattner, Kirk R. Maples, Yvonne Freund, Virginia Sanders, Yi Xia, Stephen J. Baker, James A. Nieman, Xiaosong Lu, Marcelo Sales, Rashmi Sharma, Rajeshwar Singh, Robert T. Jacobs, Daitao Chen, Michael Richard Kevin Alley