Abstract: A programmable memory device includes a read only memory (ROM) block to store instructions associated with functionality of the programmable memory device. The device includes a memory array having a set of reserved pages to store updates to be performed on the ROM block. The device includes a controller coupled to the ROM block and the memory array. The controller is to execute the instructions to: execute a set features command; program, in execution of the set features command, a set of sub-feature parameters to a specified feature address of the set of reserved pages, wherein the set of sub-feature parameters are to trigger operation within a ROM-emulated memory (REM) profile mode; and program a REM-profiled page of the set of reserved pages with REM data received from a host system.

Abstract: A holographic sight comprises a unitary optical component carrier. The unitary optical component carrier may comprise a body with a first receptacle configured to receive a laser diode, a second receptacle configured to receive a mirror, a third receptacle configured to receive a collimating optic, a fourth receptacle configured to receive a grating, and a fifth receptacle configured to receive an image hologram. A laser diode may be received within opposing walls formed by the first receptacle. A mirror may be received in, and abut one or more surfaces of the second receptacle. A collimating optic may be received in, and abut one or more surfaces of the third receptacle. A grating may be received in, and abut one or more surfaces of the fourth receptacle. A hologram image may be received in, and abut one or more surfaces of the fifth receptacle.

Abstract: A linear actuator, for controlling movement of a control surface of an aircraft, includes a screw, a primary load path and secondary nut engaged with the screw, and an engagement member. The engagement member moves from an ambush position, maintained by the primary load path or the secondary nut, to an engaged position, restricting relative movement between the primary load path and the secondary nut. The restricted relative movement may occur in response to free relative axial movement of the primary load path and the secondary nut caused by a failure of the primary load path of the linear actuator. A sensor of the linear actuator is configured to sense the failure of the primary load path and the free relative axial movement of the primary load path and the secondary nut.

Abstract: Various systems, methods, and processes for optimizing the performance of a consolidated full backup of a restored virtual machine are disclosed. Changed data and metadata associated with the changed data is received from a hypervisor at a backup module. The hypervisor supports a virtual machine, and the virtual machine employs virtual disks. A confirmation is sent to the hypervisor from the backup module indicating that a full backup of the virtual disks has been created.

Abstract: Peptide-antibody complexes, including fusions and conjugates, that target or accumulate in target cells, such as tumors and diseased cells, or enhance the immune system are disclosed. In some embodiments, such complexes function as platforms for attaching and targeting one or more therapeutic agents or detectable agents, including radioisotopes, detectable labels, and/or cytotoxic agents, to target cells in the central nervous system or across the blood brain barrier, cancerous cells, or target cells recognized by the antibody in such complexes. In some complexes, the peptide serves as the targeting mechanism, while other embodiments contemplate the antibody as the targeting mechanism. Peptides and/or antibodies can be engineered to deliver various effector functions in various embodiments. Peptide-antibody complexes that function as immunotherapies and enhance a body's immune system in detecting and/or destroying diseased cells or pathogens are also disclosed.

Abstract: A connector block that permits simultaneous and continuous interconnection of the three leads of the epicardial pacing wires, the pacemaker, and the ECG monitor on clear separately labeled connectors is provided. Circuitry is provided that allows the display of epicardial signals on the telemetry unit, while still preserving the ability to pace the heart from the pacemaker. When pacing the connector block prevents excessive loading of the pacer signals by the ECG monitor and/or damage to the monitor by the high-voltage pacer signals. The connector block may be used universally on all monitors without the need for sophisticated understanding of the electrical characteristics of the ECG monitor or concern for damage or improper signal loading.

Abstract: Peptides that are stable to denaturation and degradation by reducing agents, proteases, temperature, and low pH environments are disclosed. Pharmaceutical compositions and uses for peptides, peptide-active agent conjugates, and peptide-detectable agent conjugates comprising such peptides are also disclosed. Peptide compositions, peptide conjugate compositions, and pharmaceutical compositions can be formulated for various routes of delivery, such as oral delivery, and for deliver to various compartments of the body. Peptides of this disclosure are stable and display enhanced pharmacokinetics after such delivery.

Abstract: A connector block that permits simultaneous and continuous interconnection of the three leads of the epicardial pacing wires, the pacemaker, and the ECG monitor on clear separately labeled connectors is provided. Circuitry is provided that allows the display of epicardial signals on the telemetry unit, while still preserving the ability to pace the heart from the pacemaker. When pacing the connector block prevents excessive loading of the pacer signals by the ECG monitor and/or damage to the monitor by the high-voltage pacer signals. The connector block may be used universally on all monitors without the need for sophisticated understanding of the electrical characteristics of the ECG monitor or concern for damage or improper signal loading.

Abstract: A safety apparatus (10) includes a weight pan (18) removably receiving a plurality of weights (W) pivotably mounted about a pan axis (A) between frame sides (12). Wheels are rotatably mounted to the first ends of the frame sides (12). An I-shaped main frame (40) is pivotably mounted to the frame about a first frame axis (J) generally perpendicular to the pan axis (A) and also a second frame axis (E) generally parallel to the pan axis (A). By pivoting the main frame (40) about the first frame axis (J), a steering function is provided to the frame. By pivoting the main frame (40) about the second frame axis (E), the frame is pivoted between an actuated position with the weight pan (18) resting upon a surface and a transport position with the weight pan (18) spaced from the surface and with the frame moveable on the surface (102).

Abstract: Peptides that home, migrate to, distribute to, accumulate in, are directed to, and/or bind to tumors, cancerous tissues and cells thereof are disclosed. Pharmaceutical compositions and uses for peptides, peptide-active agent complexes comprising such peptides, or peptide-detectable agent complexes comprising such peptides are additionally disclosed. Such compositions can be formulated for targeted or untargeted delivery of a drug to a target region, tissue, structure or cell. Targeted compositions of the disclosure can deliver peptide, peptide-active agent complexes, or peptide-detectable agent complexes to target regions, tissues, structures or cells targeted by the peptide.

Abstract: Groups of bi-specific binding domain constructs (BS-BDC) to treat cancer are described. Each BS-BDC in a group targets a cancer antigen epitope and an immune cell activating epitope that is different from the cancer antigen epitope and immune cell activating epitope targeted by another BS-BDC in the group. The different cancer antigen epitopes can be on the same cancer antigen.

Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in amd/or binds to the cartilage of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of a drug to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures or cells targeted by the peptide.

Abstract: A debris disposal chute includes a plurality of tubes having rectangular cross sections of a decreasing size attached together. Flaccid members are connected between hangers pivotably mounted to a casing and the first tube and between the flaccid members of the upper tube and the next lower tube. The casing is pivotably mounted to a receptacle about an axis perpendicular to the hanger axis and the center line of the chute. A header is removably connected to the receptacle by attachment bars and includes a surface inclined towards the open entry. Weight basins are removably connected to the header by leverage connectors on opposite sides of the open entry and the attachment bars.

Abstract: Methods and systems for producing fusion proteins and peptides are disclosed. Fusion proteins and peptides created using the methods are also provided. Also provided are methods of using the fusion proteins and peptides produced according to the present disclosure.

Abstract: Peptides that home, distribute to, target, are directed to, or accumulate in tumors, cancers, or diseased cells are disclosed. Peptides that cross the blood brain barrier and home, distribute to, target, are directed to, or accumulate in the brain and in a specific region of the brain are also disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are additionally disclosed. Such compositions can be formulated for targeted or untargeted delivery of a drug to a target region, tissue, structure or cell. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures or cells targeted by the peptide.

Abstract: Methods and systems for producing fusion proteins and peptides are disclosed. Fusion proteins and peptides created using the methods are also provided. Also provided are methods of using the fusion proteins and peptides produced according to the present disclosure.

Abstract: A linear actuator, for controlling movement of a control surface of an aircraft, includes a screw, a primary load path and secondary nut engaged with the screw, and an engagement member. The engagement member moves from an ambush position, maintained by the primary load path or the secondary nut, to an engaged position, restricting relative movement between the primary load path and the secondary nut. The restricted relative movement may occur in response to free relative axial movement of the primary load path and the secondary nut caused by a failure of the primary load path of the linear actuator. A sensor of the linear actuator is configured to sense the failure of the primary load path and the free relative axial movement of the primary load path and the secondary nut.

Abstract: Provided is a wedge-shaped multilayer interlayer and a glass laminate containing such interlayer, wherein the interlayer is based on the combination of (a) an integrated multilayer interlayer sheet having an overall substantially consistent thickness and a substantially consistent thickness of an interior layer, and (b) a separate wedge-shaped film.

Abstract: A connector block that permits simultaneous and continuous interconnection of the three leads of the epicardial pacing wires, the pacemaker, and the ECG monitor on clear separately labeled connectors is provided. Circuitry is provided that allows the display of epicardial signals on the telemetry unit, while still preserving the ability to pace the heart from the pacemaker. When pacing the connector block prevents excessive loading of the pacer signals by the ECG monitor and/or damage to the monitor by the high-voltage pacer signals. The connector block may be used universally on all monitors without the need for sophisticated understanding of the electrical characteristics of the ECG monitor or concern for damage or improper signal loading.

Abstract: A safety apparatus (10) includes a weight pan (18) removably receiving a plurality of weights (W) pivotably mounted about a pan axis (A) between frame sides (12). Wheels are rotatably mounted to the first ends of the frame sides (12). An I-shaped main frame (40) is pivotably mounted to the frame about a first frame axis (J) generally perpendicular to the pan axis (A) and also a second frame axis (E) generally parallel to the pan axis (A). By pivoting the main frame (40) about the first frame axis (J), a steering function is provided to the frame. By pivoting the main frame (40) about the second frame axis (E), the frame is pivoted between an actuated position with the weight pan (18) resting upon a surface and a transport position with the weight pan (18) spaced from the surface and with the frame moveable on the surface (102).