Abstract: This invention relates to compounds that can be used to treat viral infections. The compounds are papain-like protease (PLpro) inhibitors.

Abstract: Inverted contact-aided rolling element mechanisms and devices are discussed herein. In various embodiments, the contact-aided compliant mechanism includes a first rigid component, a second rigid component, a first flexible component, a second flexible component, each of the first and second flexible components comprising a first end, a second end, and a third end, and the first and second flexible components disposed between the first and second rigid components.

Abstract: Minimally invasive compliant devices for spinal disc replacement are discussed herein. In various embodiments, the device comprises a contact-aided compliant mechanism comprising a first rigid component, a second rigid component, a third rigid component, a first flexible component, a second flexible component. Additionally, the first flexible component can be disposed between the first rigid component and the second rigid component while the second flexible components disposed between the second rigid component and the third rigid component. In many embodiments, the rigid components can include a bearing surface, wherein the bearing surface selectively engages another bearing surface of another rigid component.

Abstract: Methods and systems for classification and recovery of certain solids from streams, such as liquid waste streams. Methods including classification with at least one solid bowl centrifuge, followed by a valorization procedure. The valorization procedure may be a flotation procedure, which may include a single-step or two-step procedure.

Abstract: A method of operating a HVAC system is provided. The method includes removing heat from a working fluid using an evaporator and a blower that moves airflow across the evaporator. The method includes measuring at least one gas property value of a fluid surrounding the evaporator using a leak detection sensor. The method includes determining a control setpoint for a maximum allowable concentration of working fluid in the fluid surrounding the evaporator, where the control setpoint corresponds to a gas property value associated with a threshold percentage of a lower flammability limit of the first refrigerant in air at the operating temperature. The method includes determining that the at least one gas property value of the working fluid exceeds the control setpoint. If exceeded, the method includes closing a value that regulates the flow of working fluid to the evaporator and initiating the blower to move airflow across the evaporator.

Abstract: A cognate specification system manages and enforces digital, canonical representations of entities that are added to and in the system by creating a composite entity key (“EntityKey”) that uniquely and immutably identifies each entity within the system, and that is created based upon the attributes of the entity rather than being arbitrarily assigned. Entities may be organized into various types or cognates, each associated with distinct sets of attributes. A physical or digital referent may be added to the system as an entity by specifying attributes. In such a system, any entity, whether a physical or digital referent, a process, or other type, is uniquely and verifiably identifiable, and may be linked to or associated with other entities, allowing users of the system to produce and access specification granularity beyond traditional approaches focused on systems interoperability.

Abstract: A cognate specification system manages and enforces digital, canonical representations of entities that are added to and in the system by creating a composite entity key (“EntityKey”) that uniquely and immutably identifies each entity within the system, and that is created based upon the attributes of the entity rather than being arbitrarily assigned. Entities may be organized into various types or cognates, each associated with distinct sets of attributes. A physical or digital referent may be added to the system as an entity by specifying attributes. In such a system, any entity, whether a physical or digital referent, a process, or other type, is uniquely and verifiably identifiable, and may be linked to or associated with other entities, allowing users of the system to produce and access specification granularity beyond traditional approaches focused on systems interoperability.

Abstract: An ion generating device can include a housing having an opening, an anode and a cathode disposed within the housing and having a space between them in fluid communication with the opening, a power source having a negative terminal and a positive terminal with a first connection between the negative terminal and the anode and a second connection between the positive terminal and the cathode, and an air mover disposed to direct an air flow through the space and out of the opening.

Abstract: A cognate specification system manages and enforces digital, canonical representations of entities that are added to and in the system by creating a composite entity key (“EntityKey”) that uniquely and immutably identifies each entity within the system, and that is created based upon the attributes of the entity rather than being arbitrarily assigned. Entities may be organized into various types or cognates, each associated with distinct sets of attributes. A physical or digital referent may be added to the system as an entity by specifying attributes. In such a system, any entity, whether a physical or digital referent, a process, or other type, is uniquely and verifiably identifiable, and may be linked to or associated with other entities, allowing users of the system to produce and access specification granularity beyond traditional approaches focused on systems interoperability.

Abstract: An ion generating device can include a housing having an opening, an anode and a cathode disposed within the housing and having a space between them in fluid communication with the opening, a power source having a negative terminal and a positive terminal with a first connection between the negative terminal and the anode and a second connection between the positive terminal and the cathode, and an air mover disposed to direct an air flow through the space and out of the opening.

Abstract: A cognate specification system manages and enforces digital, canonical representations of entities that are added to and in the system by creating a composite entity key (“EntityKey”) that uniquely and immutably identifies each entity within the system, and that is created based upon the attributes of the entity rather than being arbitrarily assigned. Entities may be organized into various types or cognates, each associated with distinct sets of attributes. A physical or digital referent may be added to the system as an entity by specifying attributes. In such a system, any entity, whether a physical or digital referent, a process, or other type, is uniquely and verifiably identifiable, and may be linked to or associated with other entities, allowing users of the system to produce and access specification granularity beyond traditional approaches focused on systems interoperability.

Abstract: A multifunction blowout preventer has a housing formed from a single piece of material, which has a central bore, a bottom connection, a gate valve section, an integrated ram assembly/flow tee section, and a top connection. The blowout preventer optionally includes a gas lift/electrical ports section. The components of the blowout preventer are radially offset and/or staggered from one another about the periphery of the housing to help minimize the height of the blowout preventer.

Abstract: An ion generating device can include a housing having an opening, an anode and a cathode disposed within the housing and having a space between them in fluid communication with the opening, a power source having a negative terminal and a positive terminal with a first connection between the negative terminal and the anode and a second connection between the positive terminal and the cathode, and an air mover disposed to direct an air flow through the space and out of the opening.

Abstract: An adjustable blowout preventer may be configured to be adjustable, such that a central bore of the blowout preventer may be adjusted or repositioned. The blowout preventer may include one or more adjustment mechanisms for adjusting an angle of tilt of the central bore and/or an offset distance of the central bore. The adjustment mechanisms may be arranged between a stack of the blowout preventer and a wellhead. The adjustment mechanisms may generally be tubular structures having angled and/or laterally offset bores therein. The adjustment mechanisms may be configured to be rotatable, such that rotation of the mechanisms may change an angle of tilt and/or lateral offset of the blowout preventer central bore, or portions thereof.

Abstract: A blowout preventer (BOP) and a seal anti-extrusion apparatus is provided for well control about a tubular such as a polish rod. Each of opposing ram blocks support a semi-circular primary seal and at least one downstream backup ring. An extrusion gap is formed between the ram block and the rod. The backup ring has profile that is axially compressible by the primary seal when activated, causing an inner diameter diminish, and closing the extrusion gap for improved sealing integrity of the primary seal.

Abstract: Apparatus and methodologies are provided for modifying the wellhead structure of a production well to seal the production well before subterranean fracturing operations. The apparatus includes an enclosure tubular and adapter 5 for sealingly engaging the polish rod extending from the wellhead structure, while maintaining the entire rod string in tension in a manner to ensure that the string and its connection with the downhole pump are not compromised. More specifically, the present preparations involve retaining the rod string in tension while removing at least the stuffing box from the wellhead structure, and 10 temporarily installing the enclosure tubular and adapter to seal the wellhead, preventing wellbore blowouts.

Abstract: An ion generating device can include a housing having an opening, an anode and a cathode disposed within the housing and having a space between them in fluid communication with the opening, a power source having a negative terminal and a positive terminal with a first connection between the negative terminal and the anode and a second connection between the positive terminal and the cathode, and an air mover disposed to direct an air flow through the space and out of the opening.

Abstract: A multifunction blowout preventer has a housing formed from a single piece of material, which has a central bore, a bottom connection, a gate valve section, an integrated ram assembly/flow tee section, and a top connection. The blowout preventer optionally includes a gas lift/electrical ports section. The components of the blowout preventer are radially offset and/or staggered from one another about the periphery of the housing to help minimize the height of the blowout preventer.