Patents by Inventor James A. Robbins
James A. Robbins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11940254Abstract: A projectile designed to be lead-free and have a ballistic coefficient ranging from about 0.13 to about 0.80 or greater for enhanced energy/performance at extended ranges may have an elongated body formed with a jacket including a wall having an end defining an ogive portion and a cavity or recess defined within the jacket and in which a core is received. The projectile can be configured in various calibers and sizes. The projectile core may be formed from a plurality of core sections, and at least one of the plurality of core sections may include tungsten powder and a lead-free binder material pressed together to form a substantially cylindrical shape or compact. One or more of the core sections further can be sintered, and the one or more core sections may be received in an end-to-end relationship within the cavity defined by the jacket to form a stacked, sectional core.Type: GrantFiled: July 11, 2022Date of Patent: March 26, 2024Assignee: Barnes Bullets, LLCInventors: Jason Wesley Robbins, Carl Carter, Christopher Creed Crosby, Gregory S. Christensen, Mitchell Dean Kukson, Brian James Simons, Greggory Sloan, Michael Painter
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Patent number: 11622864Abstract: An expandable intervertebral implant includes a superior plate having a proximal end, an opposing distal end, and a threaded first hole. An inferior plate has a proximal end, an opposing distal end, and a first bore, the inferior plate at least partially bounding an elongated channel that communicates with the first bore. A first lift screw includes a gear wheel rotatably received within the first bore of the inferior plate and a threaded stem projecting from the gear wheel and being threaded into the first hole of the superior plate. A drive screw is rotatably disposed within the channel of the inferior plate, the drive screw having a worm that engages with the gear wheel such that rotation of the drive screw facilitates rotation of the first lift screw which in turn facilitates movement of the superior plate relative to the inferior plate.Type: GrantFiled: June 25, 2020Date of Patent: April 11, 2023Assignee: Innovasis, Inc.Inventors: Daniel E. Gerbec, James Robbins, Eric Wieser, Ronald K. Groberg, Brent A. Felix
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Publication number: 20220411792Abstract: Provided herein, in some aspects, are compositions of nucleic acids comprising an initial transcribed sequence and unique nucleic acid designs for high-yield and cost-effective production of ribonucleic acids.Type: ApplicationFiled: December 4, 2020Publication date: December 29, 2022Inventors: James Robbins ABSHIRE, Himanshu DHAMANKAR, William FARMER, Christopher GREGG
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Publication number: 20220371965Abstract: A green ceramic composition comprising (i) ceramic particles, (ii) a synthetic polymeric binder, the synthetic polymeric binder having (a) monomeric units deriving from a soft monomer, (b) monomeric units deriving from a hard non-acidic monomer, (c) monomeric units deriving from an acidic monomer, and (d) monomeric units deriving from a hydroxy-functionalized monomer, and (iii) water.Type: ApplicationFiled: September 21, 2020Publication date: November 24, 2022Inventors: Carla B. McBAIN, Carl SORRELL, James ROBBINS
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Publication number: 20220370599Abstract: In the various aspects and embodiments, this disclosure provides messenger RNA (mRNA) constructs for therapeutic delivery, as well as methods for making such mRNA constructs and pharmaceutical compositions comprising the same (including mRNA vaccine compositions). In still other aspects, the invention provides methods for treating patients by expression of therapeutic proteins, including for preventing or reducing probability of infection by, or illness involving, a virus. Exemplary viruses include coronaviruses (such as SARS-CoV-2 and variants therefore) and influenza viruses, among others.Type: ApplicationFiled: May 2, 2022Publication date: November 24, 2022Inventors: James Robbins ABSHIRE, Christopher J.H. DAVITT, Ian HILL, Lorenzo AULISA, Marcelo SAMSA, Nabanita DE, Michael HUDSON, Rachit JAIN, Himanshu DHAMANKAR, William FARMER, Christopher GREGG
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Publication number: 20220195364Abstract: The current subject matter includes methods, systems, articles, and techniques to deliver material to anucleate cells, such as red blood cells. Using a rapid deformation based microfluidic system, loading of red blood cells with macromolecules of different sizes has been shown. Although delivery to some mammalian cells, such as cancer cell lines and fibroblasts had been previously demonstrated using this technique, those designs were incompatible with RBCs that have dramatically different physical properties. Through the use of smaller constriction sizes, high speeds and different buffers successful delivery to red blood cells can be achieved. By enabling robust delivery to red blood cells in a simple, scalable manner, the current subject matter can be implemented in a diversity of applications that deliver material to study red blood cell diseases and/or use red blood cells as a therapeutic platform. Related apparatus, systems, techniques, and articles are also described.Type: ApplicationFiled: March 8, 2022Publication date: June 23, 2022Applicant: Massachusetts Institute of TechnologyInventors: Armon R. Sharei, Klavs F. Jensen, James Robbins Abshire, Jacquin Clarence Niles
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Patent number: 11330746Abstract: A system and method for reworking a flip chip includes use of a mill to remove an old flip chip, and a pick-and-place device for putting a new flip chip in place at the same location. The process may be automated, with the removal and the placement occurring sequentially without need for operator intervention. Other devices and processes may be part of the system/machine and process, for example cleaning following the milling, fluxing prior to the placement, and heating to cause solder reflow, to secure the new flip chip in place. Underfill may be employed to make for a more mechanically robust mounting of the new flip chip.Type: GrantFiled: February 27, 2019Date of Patent: May 10, 2022Assignee: Raytheon CompanyInventors: James A. Robbins, Jeffrey A. Shubrooks
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Patent number: 11299698Abstract: The current subject matter includes methods, systems, articles, and techniques to deliver material to anucleate cells, such as red blood cells. Using a rapid deformation based microfluidic system, loading of red blood cells with macromolecules of different sizes has been shown. Although delivery to some mammalian cells, such as cancer cell lines and fibroblasts had been previously demonstrated using this technique, those designs were incompatible with RBCs that have dramatically different physical properties. Through the use of smaller constriction sizes, high speeds and different buffers successful delivery to red blood cells can be achieved. By enabling robust delivery to red blood cells in a simple, scalable manner, the current subject matter can be implemented in a diversity of applications that deliver material to study red blood cell diseases and/or use red blood cells as a therapeutic platform. Related apparatus, systems, techniques, and articles are also described.Type: GrantFiled: January 9, 2018Date of Patent: April 12, 2022Assignee: Massachusetts Institute of TechnologyInventors: Armon R. Sharei, Klavs F. Jensen, James Robbins Abshire, Jacquin Clarence Niles
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Publication number: 20220096525Abstract: Provided herein, are compositions based on retroviruses (e.g., lentiviruses) comprising one or more nucleic acid molecules encoding retroviral Pol polyprotein components and a nucleic acid molecule comprising one or more transgene sequences flanked by long terminal repeat sequences, for delivery of the one or more transgenes to a target cell ex vivo or in vivo. The compositions are useful for delivering to a target cell (e.g., hematopoietic stem cells (HSCs), liver cells, ocular cells, muscle cells, epithelial cells, T cells, etc.) and/or stably expressing any transgene (e.g., beta-globin, Factor VIII, RP GTPase regulator (RPGR), dystrophin, cystic fibrosis transmembrane conductance regulator (CFTR), a chimeric antigen receptor, etc.) with a biological effect to treat and/or ameliorate the symptoms associated with any disorder related to gene expression (e.g., sickle cell disease, beta-thalassemia, haemophilia B, retinitis pigmentosa, Duchenne muscular dystrophy, cystic fibrosis, cancer, etc.).Type: ApplicationFiled: July 16, 2021Publication date: March 31, 2022Inventors: Christian Matranga, James Robbins Abshire, Andrey Jury Zarur, Kelsey A. Haugh, Katherine J. Williams
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Publication number: 20220064688Abstract: Provided herein, in some aspects, are methods and compositions for cell-free production of ribonucleic acid.Type: ApplicationFiled: March 15, 2021Publication date: March 3, 2022Applicant: GreenLight Biosciences, Inc.Inventors: William Jeremy Blake, Drew S. Cunningham, Daniel MacEachran, Mehak Gupta, James Robbins Abshire
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Publication number: 20210309691Abstract: Provided herein, in some embodiments, are methods and composition for the production of nucleoside triphosphates and ribonucleic acids.Type: ApplicationFiled: November 10, 2020Publication date: October 7, 2021Applicant: GreenLight Biosciences, Inc.Inventors: Drew S. Cunningham, Daniel MacEachran, James Robbins Abshire, Himanshu Dhamankar, Ifeyinwa Iwuchukwu, Mehak Gupta, Matthew Eduardo Moura, Naveen Sudharsan, Nicholas Skizim, Rachit Jain, Karthikeyan Ramachandriya
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Patent number: 10954541Abstract: Provided herein, in some aspects, are methods and compositions for cell-free production of ribonucleic acid.Type: GrantFiled: April 6, 2017Date of Patent: March 23, 2021Assignee: GreenLight Biosciences, Inc.Inventors: William Jeremy Blake, Drew S. Cunningham, Daniel MacEachran, Mehak Gupta, James Robbins Abshire
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Publication number: 20200405499Abstract: An expandable intervertebral implant includes a superior plate having a proximal end, an opposing distal end, and a threaded first hole. An inferior plate has a proximal end, an opposing distal end, and a first bore, the inferior plate at least partially bounding an elongated channel that communicates with the first bore. A first lift screw includes a gear wheel rotatably received within the first bore of the inferior plate and a threaded stem projecting from the gear wheel and being threaded into the first hole of the superior plate. A drive screw is rotatably disposed within the channel of the inferior plate, the drive screw having a worm that engages with the gear wheel such that rotation of the drive screw facilitates rotation of the first lift screw which in turn facilitates movement of the superior plate relative to the inferior plate.Type: ApplicationFiled: June 25, 2020Publication date: December 31, 2020Inventors: Daniel E. Gerbec, James Robbins, Eric Wieser, Ronald K. Groberg, Brent A. Felix
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Patent number: 10858385Abstract: Provided herein, in some embodiments, are methods and composition for the production of nucleoside triphosphates and ribonucleic acids.Type: GrantFiled: November 20, 2018Date of Patent: December 8, 2020Assignee: GreenLight Biosciences, Inc.Inventors: Drew S. Cunningham, Daniel MacEachran, James Robbins Abshire, Himanshu Dhamankar, Ifeyinwa Iwuchukwu, Mehak Gupta, Matthew Eduardo Moura, Naveen Sudharsan, Nicholas Skizim, Rachit Jain, Karthikeyan Ramachandriya
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Publication number: 20200001508Abstract: Two shot injection molding processes are disclosed for making thermoplastic parts of two different compositions, the second shot composition having a higher thermal conductivity than the first, and the mold cavity surface temperature is greater than 70° C., preferably 70-100° C. In embodiments, the cavity surface temperature is within 20° C. of the Vicat temperature for the composition being injected, the cavity pressure is between 20 and 150 MPa, and the melt temperature of the second shot material is 200-400° C., or 250-340° C. The resulting molded part provides for improved thermal conductivity between the two molded compositions.Type: ApplicationFiled: March 7, 2017Publication date: January 2, 2020Inventors: James LORENZO, James ROBBINS, Jessee MCCANNA, Terry DAVIS
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Patent number: 10464274Abstract: A thermoforming trim press has one or more connecting arms for driving a movable platen, each arm having a pivotal connection between two adjacent sections of each connecting arm which is normally locked during normal press operation whereby the movable platen is able to move further back from a normal retracted position to increase the available clearance when changing or maintaining tools mounted on the movable platen. The pivoting ability of the connecting arm sections also simplifies adjusting the stroke of the press. A counterweight may be driven by the crank pins to match the press stroke adjustments and to thereby correspond the movement of the counterweight to the movement of the movable platen.Type: GrantFiled: December 7, 2015Date of Patent: November 5, 2019Inventors: James Martin, Doug Harvey, James Robbins, Kevin John Daley
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Publication number: 20190269050Abstract: A system and method for reworking a flip chip includes use of a mill to remove an old flip chip, and a pick-and-place device for putting a new flip chip in place at the same location. The process may be automated, with the removal and the placement occurring sequentially without need for operator intervention. Other devices and processes may be part of the system/machine and process, for example cleaning following the milling, fluxing prior to the placement, and heating to cause solder reflow, to secure the new flip chip in place. Underfill may be employed to make for a more mechanically robust mounting of the new flip chip.Type: ApplicationFiled: February 27, 2019Publication date: August 29, 2019Inventors: James A. Robbins, Jeffrey A. Shubrooks
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Publication number: 20190144489Abstract: Provided herein, in some embodiments, are methods and composition for the production of nucleoside triphosphates and ribonucleic acids.Type: ApplicationFiled: November 20, 2018Publication date: May 16, 2019Applicant: GreenLight Biosciences, Inc.Inventors: Drew S. Cunningham, Daniel MacEachran, James Robbins Abshire, Himanshu Dhamankar, Ifeyinwa Iwuchukwu, Mehak Gupta, Matthew Eduardo Moura, Naveen Sudharsan, Nicholas Skizim, Rachit Jain, Karthikeyan Ramachandriya
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Patent number: 10039563Abstract: A suturer may include a base mechanism. The base mechanism may include a first arm having a first driving member. The base mechanism may include a second arm having a second driving member. The suturer may be configured to selectively pass a needle from an enclosed position within the first arm to an enclosed position within the second arm.Type: GrantFiled: March 14, 2014Date of Patent: August 7, 2018Assignee: INVICTUS MEDICAL INNOVATIONS, LLCInventors: Bryan C. Tagge, Adam Liberatore, Daniel Gerbec, James Robbins
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Publication number: 20180201889Abstract: The current subject matter includes methods, systems, articles, and techniques to deliver material to anucleate cells, such as red blood cells. Using a rapid deformation based microfluidic system, loading of red blood cells with macromolecules of different sizes has been shown. Although delivery to some mammalian cells, such as cancer cell lines and fibroblasts had been previously demonstrated using this technique, those designs were incompatible with RBCs that have dramatically different physical properties. Through the use of smaller constriction sizes, high speeds and different buffers successful delivery to red blood cells can be achieved. By enabling robust delivery to red blood cells in a simple, scalable manner, the current subject matter can be implemented in a diversity of applications that deliver material to study red blood cell diseases and/or use red blood cells as a therapeutic platform. Related apparatus, systems, techniques, and articles are also described.Type: ApplicationFiled: January 9, 2018Publication date: July 19, 2018Inventors: Armon R. Sharei, Klavs F. Jensen, James Robbins Abshire, Jacquin Clarence Niles