Patents by Inventor James A. S. Nightingale

James A. S. Nightingale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid pharmaceutical dispersions with enhanced bioavailability
    Patent number: 8337899
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: December 25, 2012
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • SOLID PHARMACEUTICAL DISPERSIONS WITH ENHANCED BIOAVAILABILITY
    Publication number: 20120292797
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
    Type: Application
    Filed: July 27, 2012
    Publication date: November 22, 2012
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • Pharmaceutical Compositions of Dispersions of Amorphous Drugs Mixed with Polymers
    Publication number: 20120295988
    Abstract: A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
    Type: Application
    Filed: July 31, 2012
    Publication date: November 22, 2012
    Inventors: Walter C. Babcock, William J. Curatolo, Dwayne T. Friesen, Rodney J. Ketner, Julian B. Lo, James A. S. Nightingale, Ravi M. Shanker, James B. West
  • SOLID PHARMACEUTICAL DISPERSIONS WITH ENHANCED BIOAVAILABILITY
    Publication number: 20120288542
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
    Type: Application
    Filed: July 20, 2012
    Publication date: November 15, 2012
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • PHARMACEUTICAL COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS
    Publication number: 20120277315
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Application
    Filed: June 12, 2012
    Publication date: November 1, 2012
    Inventors: Marshall D. Crew, William J. Curatolo, Dwayne T. Friesen, Michael Jon Gumkowski, Dougles A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • PHARMACEUTICAL COMPOSITIONS PROVIDING ENHANCED DRUG CONCENTRATIONS
    Publication number: 20120259022
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Application
    Filed: June 19, 2012
    Publication date: October 11, 2012
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
  • Solid pharmaceutical dispersions with enhanced bioavailability
    Patent number: 8263128
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: September 11, 2012
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • Solid pharmaceutical dispersions with enhanced bioavailability
    Patent number: 8257741
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: September 4, 2012
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers
    Patent number: 8236328
    Abstract: A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
    Type: Grant
    Filed: July 8, 2008
    Date of Patent: August 7, 2012
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, William J. Curatolo, Dwayne T. Friesen, Rodney J. Ketner, Julian B. Lo, James A. S. Nightingale, Ravi M. Shanker, James B. West
  • Pharmaceutical compositions providing enhanced drug concentrations
    Patent number: 8202912
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: June 19, 2012
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
  • Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
    Patent number: 8197848
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: June 12, 2012
    Assignee: Bend Research, Inc.
    Inventors: Marshall D. Crew, William J. Curatolo, Dwayne T. Friesen, Michael J. Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • PHARMACEUTICAL COMPOSITIONS PROVIDING ENHANCED DRUG CONCENTRATIONS
    Publication number: 20110294902
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Application
    Filed: August 11, 2011
    Publication date: December 1, 2011
    Inventors: William J. CURATOLO, Ravi M. Shanker, Walter C. Babccck, Dwayne T. Friesen, James A.S. Nightingale, Douglas A. Lorenz
  • Pharmaceutical compositions of cholesteryl ester transfer protein inhibitor
    Patent number: 8048452
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: November 1, 2011
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Dwayne T. Friesen, Michael J. Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • Pharmaceutical compositions providing enhanced drug concentrations
    Patent number: 8026286
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: September 27, 2011
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
  • PHARMACEUTICAL SOLID DISPERSIONS
    Publication number: 20100256110
    Abstract: A composition comprises a solid dispersion comprising a low-solubility drug and at least one polymer. At least a major portion of the drug in the dispersion is amorphous. The polymer has a glass transition temperature of at least 100° C. measured at a relative humidity of fifty percent. Another aspect of the invention comprises the same composition except that the dispersion has a glass transition temperature of at least 50° C. at a relative humidity of fifty percent. In another aspect of the invention, a composition comprises a solid dispersion comprising a low-solubility drug and a stabilizing polymer. At least a major portion of the drug in the dispersion is amorphous. The composition also includes a concentration-enhancing polymer that increases the concentration of the drug in a use environment. The stabilizing polymer has a glass transition temperature that is greater than the glass transition temperature of the concentration-enhancing polymer at a relative humidity of 50%.
    Type: Application
    Filed: May 25, 2010
    Publication date: October 7, 2010
    Inventors: Walter C. Babcock, Dwayne T. Friesen, James A.S. Nightingale, Ravi M. Shanker
  • Controlled release by extrusion of solid amorphous dispersions of drugs
    Patent number: 7550158
    Abstract: Controlled release dosage forms for low solubility drugs are disclosed wherein an amorphous solid dispersion of the drug is coated with a non-dissolving and non-eroding coating that controls the influx of water to the core so as to cause extrusion of a portion of the core, as well as a method of treating a disease or disorder comprising administering such dosage form to a person.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: June 23, 2009
    Assignee: Bend Research, Inc.
    Inventors: Leah E. Appel, William J. Curatolo, Scott M. Herbig, James A. S. Nightingale, Avinash G. Thombre
  • Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers
    Publication number: 20090011024
    Abstract: A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
    Type: Application
    Filed: July 8, 2008
    Publication date: January 8, 2009
    Inventors: Walter C. Babcock, William J. Curatolo, Dwayne T. Friesen, Rodney J. Ketner, Julian B. Lo, James A.S. Nightingale, Ravi M. Shanker, James B. West
  • Pharmaceutical compositions of a sparingly soluble glycogen phosphorylase inhibitor
    Patent number: 7235260
    Abstract: Pharmaceutical compositions of a particularly effective sparingly soluble glycogen phosphorylase inhibitor are disclosed, as well as methods of making such compositions and dosage forms from such compositions.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: June 26, 2007
    Assignee: Pfizer Inc
    Inventors: Marshall D. Crew, Dwayne T. Friesen, Bruno C. Hancock, Chris Macri, James A. S. Nightingale, Ravi M. Shankar
  • Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
    Patent number: 7235259
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: June 26, 2007
    Assignee: Pfizer Inc
    Inventors: Marshall D. Crew, William J. Curatolo, Dwayne T. Friesen, Michael Jon Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
    Patent number: 7115279
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: October 3, 2006
    Inventors: William J. Curatolo, Dwayne T. Friesen, Michael J. Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker