Abstract: Materials and methods to control a nutrient feed in a cell culture process is provided. A sample is received from a bioreactor comprising a cell culture. A viable cell density and a residual nutrient measurement are determined from the received sample. A daily nutrient feeding target is calculated based on the viable cell density and the residual nutrient measurement. The nutrient is fed to the bioreactor according to the calculated daily nutrient feeding target.

Abstract: An electronic device detects a gesture input while displaying first content including a first hyperlink in a first window and a second window that includes second content. In response to detecting the gesture input, and in accordance with a determination that the gesture input corresponds to a first gesture type on the first hyperlink, the electronic device replaces display of the first content in the first window with display of third content that is associated with the first hyperlink. In response to detecting the gesture input, and in accordance with a determination that the gesture input corresponds to a second gesture type on the first hyperlink, the electronic device replaces display of the second content in the second window with display of the third content that is associated with the first hyperlink.

Abstract: An electronic device detects a gesture input while displaying first content including a first hyperlink in a first window and a second window that includes second content. In response to detecting the gesture input, and in accordance with a determination that the gesture input corresponds to a first gesture type on the first hyperlink, the electronic device replaces display of the first content in the first window with display of third content that is associated with the first hyperlink. In response to detecting the gesture input, and in accordance with a determination that the gesture input corresponds to a second gesture type on the first hyperlink, the electronic device replaces display of the second content in the second window with display of the third content that is associated with the first hyperlink.

Abstract: The communications management systems manage access to a local area network or network content by external users, applications, and devices. The systems and methods are implemented on a network appliance to manage content within the network and facilitate content transmission through a firewall that separates the network from a larger networking environment, such as the World Wide Web.

Abstract: A cerebral cooling device that uses a pressurized source to deliver a fluid that evaporates in the nasal cavity to provide cooling and has a balloon on the distal end that inflates from some of the pressure front the pressurized source. The device includes a nasal catheter having delivery ports located in the distal region and a balloon on the distal end. The proximal end of the catheter is in fluid communication with a pressurized source of a low boiling point fluid. A manifold located between the pressurized source and the catheter distributes the fluid and pressure from the pressurized source to a first lumen of the catheter to inflate the balloon and to a second lumen of the catheter through the delivery ports to cool the nasal cavity. A check valve in the manifold ensures that the fluid and pressure are first delivered to the balloon.

Abstract: An ablation device, including a catheter and an ablation element incorporating one or more balloons at the distal end of the catheter, has a continuous passageway extending through it from the proximal end of the catheter to the distal side of the expandable ablation element. The ablation device ablates tissue by subjecting it to ultrasound energy, cryogenic energy, chemical, laser beam, microwave, or radiation energy. A probe carrying electrodes is introduced through this passageway and deploys, under the influence of its own resilience, to a structure incorporating a loop which is automatically aligned with the axis of the expandable ablation device, so that minimal manipulation is required to place the probe. Pulmonary vein potential is monitored in real time via the electrodes. The probe may have an atraumatic tip with a ball formed at the leading edge. The atraumatic tip prevents any tissue damage such as perforation of heart wall.

Abstract: The communications management systems manage access to a local area network or network content by external users, applications, and devices. The systems and methods are implemented on a network appliance to manage content within the network and facilitate content transmission through a firewall that separates the network from a larger networking environment, such as the World Wide Web.

Abstract: A cerebral cooling device that uses a pressurized source to deliver a fluid that evaporates in the nasal cavity to provide cooling and has a balloon on the distal end that inflates from some of the pressure front the pressurized source. The device includes a nasal catheter having delivery ports located in the distal region and a balloon on the distal end. The proximal end of the catheter is in fluid communication with a pressurized source of a low boiling point fluid. A manifold located between the pressurized source and the catheter distributes the fluid and pressure from the pressurized source to a first lumen of the catheter to inflate the balloon and to a second lumen of the catheter through the delivery ports to cool the nasal cavity. A check valve in the manifold ensures that the fluid and pressure are first delivered to the balloon.

Abstract: The inventive communications management systems manage access to a local area network or network content by external users, applications, and devices. The systems and methods are implemented on a network appliance to manage content within the network and facilitate content transmission through a firewall that separates the network from a larger networking environment, such as the World Wide Web. Other applications operating on the network appliance are made firewall aware so that existing network appliance identity schemes can be used to also control gate access to and from the network, to and from applications that run on the network appliance, and to and from other applications that run on the local network. Because the firewall is integrated closely with other application on the network appliance, after the external user is granted access to the network, network applications can control and terminate access through the firewall as desired.

Abstract: A cerebral cooling device that uses a pressurized source to deliver a fluid that evaporates in the nasal cavity to provide cooling and has a balloon on the distal end that inflates from some of the pressure from the pressurized source. The device includes a nasal catheter having delivery ports located in the distal region and a balloon on the distal end. The proximal end of the catheter is in fluid communication with a pressurized source of a low boiling point fluid. A manifold located between the pressurized source and the catheter distributes the fluid and pressure from the pressurized source to a first lumen of the catheter to inflate the balloon and to a second lumen of the catheter through the delivery ports to cool the nasal cavity. A check valve in the manifold ensures that the fluid and pressure are first delivered to the balloon.

Abstract: A cardiac ablation device treats atrial fibrillation by directing and focusing ultrasonic waves into a ring-like ablation region (A). The device desirably is steerable and can be moved between a normal disposition, in which the ablation region lies parallel to the wall of the heart for ablating a loop-like lesion, and a canted disposition, in which the ring-like focal region is tilted relative to the wall of the heart, to ablate only a short, substantially linear lesion. The ablation device desirably includes a balloon reflector structure (18, 1310) and an ultrasonic emitter assembly (23, 1326), and can be steered and positioned without reference to engagement between the device and the pulmonary vein or ostium. A contrast medium (C) can be injected through the ablation device to facilitate imaging, so that the device can be positioned based on observation of the images.

Abstract: A cerebral cooling device that uses a pressurized source to deliver a fluid that evaporates in the nasal cavity to provide cooling and has a balloon on the distal end that inflates from some of the pressure from the pressurized source. The device includes a nasal catheter having delivery ports located in the distal region and a balloon on the distal end. The proximal end of the catheter is in fluid communication with a pressurized source of a low boiling point fluid. A manifold located between the pressurized source and the catheter distributes the fluid and pressure from the pressurized source to a first lumen of the catheter to inflate the balloon and to a second lumen of the catheter through the delivery ports to cool the nasal cavity. A check valve in the manifold ensures that the fluid and pressure are first delivered to the balloon.

Abstract: A cardiac ablation device treats atrial fibrillation by directing and focusing ultrasonic waves into a ring-like ablation region (A). The device desirably is steerable and can be moved between a normal disposition, in which the ablation region lies parallel to the wall of the heart for ablating a loop-like lesion, and a canted disposition, in which the ring-like focal region is tilted relative to the wall of the heart, to ablate only a short, substantially linear lesion. The ablation device desirably includes a balloon reflector structure (18, 1310) and an ultrasonic emitter assembly (23, 1326), and can be steered and positioned without reference to engagement between the device and the pulmonary vein or ostium. A contrast medium (C) can be injected through the ablation device to facilitate imaging, so that the device can be positioned based on observation of the images.

Abstract: An ablation device, including a catheter and an ablation element incorporating one or more balloons at the distal end of the catheter, has a continuous passageway extending through it from the proximal end of the catheter to the distal side of the expandable ablation element. The ablation device ablates tissue by subjecting it to ultrasound energy, cryogenic energy, chemical, laser beam, microwave, or radiation energy. A probe carrying electrodes is introduced through this passageway and deploys, under the influence of its own resilience, to a structure incorporating a loop which is automatically aligned with the axis of the expandable ablation device, so that minimal manipulation is required to place the probe. Pulmonary vein potential is monitored in real time via the electrodes. The probe may have an atraumatic tip with a ball formed at the leading edge. The atraumatic tip prevents any tissue damage such as perforation of heart wall.

Abstract: A synchronization system schedules the reporting of synchronization states between a synchronization client computing device and a synchronization server appliance device, based on relevant events in the synchronization process. A file system hierarchy is built by a scanning module based on recursive scanning of the file system on the synchronization client computing device. Events are detected by a file system watcher function and announced to the scanning module via an event queue. If a file state change is detected, the scanning module creates a synchronization report describing the file state change and schedules transmission of the synchronization report to the synchronization server appliance device, dependent on a prior action (e.g., a last file state change for the file, the last synchronization or upload time, the last reporting time, etc.).

Abstract: An ultrasonic transducer of the type containing a cylindrical piezoelectric active element mounted on a supporting tube is provided with a backing component made of an electrically and thermally insulating material forming a sleeve which extends between the piezoelectric element and the supporting tube. An insulating material is selected for the backing component which includes a substantial amount of entrained air. Preferably, the backing component is made of expanded polytetrafluoroethylene (EPTFE).

Abstract: A steerable catheter has a steering portion incorporating a spear cut junction of catheter material, thereby providing for a gradual change in flexibility in the steering portion. A guide tube and spring may be located inside a pull wire lumen of the catheter, with the spring distal to the guide tube so that the spring is disposed at least partially within steering section. A steering mechanism moves the pull wire linearly in order to steer the catheter.

Abstract: A steerable catheter has a steering portion incorporating a spear cut junction of catheter material, thereby providing for a gradual change in flexibility in the steering portion. A guide tube and spring may be located inside a pull wire lumen of the catheter, with the spring distal to the guide tube so that the spring is disposed at least partially within steering section. A steering mechanism moves the pull wire linearly in order to steer the catheter.

Abstract: A communication system may include a network, a server, and one or more clients. The server may verify that a communication among two or more of the clients should occur. The server may facilitate key agreement among the clients. The clients may authenticate using a key obtained via the key agreement. The communication may comprise content distribution, content synchronization, or another type of communication.