Patents by Inventor James A. Sinclair

James A. Sinclair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220155070
    Abstract: The present invention provides an apparatus adapted to survey a predetermined characteristic within a body of fluid adjacent an axis that transects the body of fluid, the apparatus comprising: a survey member interposed between first and second position defining arrangements; and at least one instrumentality associated with the survey member, each instrumentality adapted to survey the predetermined characteristic of the body of fluid adjacent the axis, wherein a survey of the predetermined characteristic is conducted over a predetermined time period. The present invention provides a method of surveying a predetermined characteristic within a body of fluid adjacent an axis that transects the body of fluid, the method comprising the steps of: deploying into a body of fluid at least one apparatus according to the first aspect of the invention; and obtaining survey data of the predetermined characteristic from one or more of the instrumentalities over the predetermined time period.
    Type: Application
    Filed: March 19, 2019
    Publication date: May 19, 2022
    Inventors: Jarrod James SINCLAIR, Brent Thomas PAPESH
  • Patent number: 9801931
    Abstract: The invention is based on the discovery of the epitope in the Stx2 protein for the 11 E1O antibody. The invention features compositions containing non-full length Stx2 polypeptides that include the 11 E1O monoclonal antibody epitope. The invention also features methods of producing anti-Stx2 antibodies specific for the 11 E1O epitope of the Stx2 protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection) with a polypeptide that includes the 11 E1O epitope or with an anti-Stx2 antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stx2 in a sample using the antibodies developed using the methods of the invention.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: October 31, 2017
    Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Alison D. O'Brien, Angela Melton-Celsa, Michael Smith, James Sinclair
  • Publication number: 20160243210
    Abstract: The invention is based on the discovery of the epitope in the Stx2 protein for the 11 E1O antibody. The invention features compositions containing non-full length Stx2 polypeptides that include the 11 E1O monoclonal antibody epitope. The invention also features methods of producing anti-Stx2 antibodies specific for the 11 E1O epitope of the Stx2 protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection) with a polypeptide that includes the 11 E1O epitope or with an anti-Stx2 antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stx2 in a sample using the antibodies developed using the methods of the invention.
    Type: Application
    Filed: February 23, 2015
    Publication date: August 25, 2016
    Inventors: Alison D. O'BRIEN, Angela MELTON-CELSA, Michael SMITH, James SINCLAIR
  • Publication number: 20160132198
    Abstract: A graphical user interface having a dashboard for people recommendation to a first user, including: a first section presenting a plurality of second users one at a time and a second section presenting a plurality of people searches one at time. The first section has: a first area showing a profile image of a corresponding user in the second users; a second area showing profile text information of the corresponding user; a third area showing profile matching information between the corresponding user and the first user; and at least one first user interface element selectable to change a selection of the corresponding user from the second users. The second section has: a fourth area showing a corresponding search in the plurality of people searches; and at least one second user interface element selectable to change a selection of the corresponding search from the plurality of people searches.
    Type: Application
    Filed: November 10, 2015
    Publication date: May 12, 2016
    Inventors: James SINCLAIR, Emma SINCLAIR
  • Publication number: 20160019645
    Abstract: A computer trading system includes a quote screening function configured to accept quotes specifying a quote amount in a price where the quote amount is greater than a minimum quote amount to produce screen quote messages and to reject quotes specifying a quote amount less than the minimum quote amount. A market view generator generates market views from those quotes which specify an amount greater than or equal to the minimum quote amount. An order screening function only accepts orders specifying an amount less than a maximum transaction amount submitted in response to the market views to produce screened order messages. A transaction processor receives screened quote messages and screened order messages and matches appropriate messages with each other. The minimum quote amount is substantially equal to or greater than the maximum transaction amount whereby a screened order message can be matched entirely with one screened quote message.
    Type: Application
    Filed: August 3, 2015
    Publication date: January 21, 2016
    Inventors: Karen Ilse Setz, Snezhana Malkin, Leong Fai Mah, Steven J. Scully, Tracey Riordan, Edward R. Howorka, James Sinclair
  • Publication number: 20160012078
    Abstract: An intelligent media management system can facilitate more organized storage of media, including photos and video. The system can be a platform that sorts media into micro groups based on sets of comparable photos, where the groups can be defined by event, sequence, people, actions, context, or other criteria. The system can include back-end technology created for the intelligent recalling of specific images (algorithms and intelligent processing) and a front-end application that delivers this data to the consumer user (e.g., an application or app). The front-end application can include a search engine that enables the user to search the micro-groups to find relevant photos and video more quickly than is possible with currently-available camera applications.
    Type: Application
    Filed: July 14, 2015
    Publication date: January 14, 2016
    Inventors: Ephraim Gabriel Kutner, Rena Rachel Kutner, Aaron David Kutner, Gershon Yarmush, Andrew Michael Moeck, James Sinclair
  • Patent number: 9054863
    Abstract: Aspects of the present invention provide machines, systems, and methods in which industrial control systems may be secured from compromise and/or disruption via authentication and firewall. In particular, an industrial controller may: randomly generate an exchange key and send the exchange key to a client device in response to a transaction request originating from the client device; combine the exchange key with a locally stored pass key to produce an authentication code; and compare a challenge key received from the client device to the authentication code to determine a match between the challenge key and the authentication code. A successful match between the challenge key and the authentication code may allow the client device to further access the industrial controller using a common industrial protocol (CIP), and a failed match between the challenge key and the authentication code may prevent the client device from further access to the industrial controller.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: June 9, 2015
    Assignee: Rockwell Automation Asia Pacific Business Center PTE. LTD.
    Inventors: Ng Pei Sin, James A. Sinclair, Taryl Jasper
  • Patent number: 8969529
    Abstract: The invention is based on the discovery of the epitope in the Stx2 protein for the 11 E1O antibody. The invention features compositions containing non-full length Stx2 polypeptides that include the 11 E1O monoclonal antibody epitope. The invention also features methods of producing anti-Stx2 antibodies specific for the 11 E1O epitope of the Stx2 protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection) with a polypeptide that includes the 11 E1O epitope or with an anti-Stx2 antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stx2 in a sample using the antibodies developed using the methods of the invention.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: March 3, 2015
    Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Alison O'Brien, Angela Melton-Celsa, Michael Smith, James Sinclair
  • Patent number: 8890696
    Abstract: A fire detector includes a sensor (4) for, in use, detecting electromagnetic radiation emitted by a flame and generating an electronic signal corresponding to the detected electromagnetic radiation. The detector further includes a processing device (2) configured to select a portion of the electronic signal corresponding to a first time period and compare the selected signal portion with at least one parameter to determine an initial presence or absence of a flame, the processing device being further configured, upon determining the initial presence of the flame, to select a further portion of the electronic signal corresponding to a further time period and comparing the further selected signal portion with at least one parameter to determine a definite presence or absence of the flame.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: November 18, 2014
    Inventor: James Sinclair Popper
  • Patent number: 8823477
    Abstract: A shielded magnetic attachment apparatus is provided, having engaged and disengaged configurations, and comprising: at least one magnet; a first casing comprising ferromagnetic material attached to one side of the at least one magnet; a second casing comprising ferromagnetic material operably magnetically attachable to the at least one magnet; and a release mechanism attached to either the first or second casing for transitioning the shielded magnetic attachment apparatus from the engaged to the disengaged configuration; wherein the shielded magnetic attachment apparatus is in the engaged configuration when the at least one magnet provides a magnetic force which acts to keep the shielded magnetic attachment apparatus in the engaged configuration, and the shielded magnetic attachment apparatus is in the disengaged configuration when not in the engaged position.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: September 2, 2014
    Assignee: They Innovate Inc.
    Inventors: Danilo Dmitro Malanczyj, Jeffrey Nathan Mclarty, Thiago Ike Avila, Michael William James Sinclair
  • Patent number: 8775297
    Abstract: A computer trading system includes a quote screening function configured to accept quotes specifying a quote amount in a price where the quote amount is greater than a minimum quote amount to produce screen quote messages and to reject quotes specifying a quote amount less than the minimum quote amount. A market view generator generates market views from those quotes which specify an amount greater than or equal to the minimum quote amount. An order screening function only-accepts orders specifying an amount less than a maximum transaction amount submitted in response to the market views to produce screened order messages. A transaction processor receives screened quote messages and screened order messages and matches appropriate messages with each other. The minimum quote amount is substantially equal to or greater than the maximum transaction amount whereby a screened order message can be matched entirely with one screened quote message.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: July 8, 2014
    Assignee: EBS Group Limited
    Inventors: Karen Ilse Setz, Snezhana Malkin, Leong Fai Mah, Steven J. Scully, Tracey Riordan, Edward R. Howorka, James Sinclair
  • Patent number: 8763559
    Abstract: Systems and methods for monitoring laboratory animals includes a tag comprising an inductive element and a capacitive element attached to a portion of a laboratory animal. The position of the portion is detected by monitoring the effect of the tag on a time-varying magnetic field having different frequencies, one near tag resonance, and one away from tag resonance.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: July 1, 2014
    Assignee: Vertex Pharmaceuticals, Incorporated
    Inventors: Philip Salzmann, Trang Nguyen, James Sinclair
  • Publication number: 20140064482
    Abstract: Aspects of the present invention provide machines, systems, and methods in which industrial control systems may be secured from compromise and/or disruption via authentication and firewall. In particular, an industrial controller may: randomly generate an exchange key and send the exchange key to a client device in response to a transaction request originating from the client device; combine the exchange key with a locally stored pass key to produce an authentication code; and compare a challenge key received from the client device to the authentication code to determine a match between the challenge key and the authentication code. A successful match between the challenge key and the authentication code may allow the client device to further access the industrial controller using a common industrial protocol (CIP), and a failed match between the challenge key and the authentication code may prevent the client device from further access to the industrial controller.
    Type: Application
    Filed: September 4, 2012
    Publication date: March 6, 2014
    Inventors: Ng Pei Sin, James A. Sinclair, Taryl Jasper
  • Publication number: 20140040103
    Abstract: An anonymous trading system includes a prime broker facility that allows a third party to trade on behalf of an institution. A deal is executed between the third party and a counter-party and a further deal is then executed between the third party and the party on whose behalf it has traded. The second deal may be for the same amount as the first deal or may be altered to include the third party's fee for conducting the first deal. Clients of the third party have prices available to them for trades made via the third party which are displayed at their trader terminals. The client sees that a better price is available though the third party than by dealing direct and selects to conduct a deal through the third party.
    Type: Application
    Filed: October 3, 2013
    Publication date: February 6, 2014
    Applicant: EBS Group Ltd.
    Inventors: James Sinclair, James A. O'Hagan, Edward R. Howorka, Neena Jain
  • Patent number: 8577784
    Abstract: An anonymous trading system includes a prime broker facility that allows a third party to trade on behalf of an institution. A deal is executed between the third party and a counter-party and a further deal is then executed between the third party and the party on whose behalf it has traded. The second deal may be for the same amount as the first deal or may be altered to include the third party's fee for conducting the first deal. Clients of the third party have prices available to them for trades made via the third party which are displayed at their trader terminals. The client sees that a better price is available though the third party than by dealing direct and selects to conduct a deal through the third party.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: November 5, 2013
    Assignee: EBS Group Limited
    Inventors: James Sinclair, James A. O'Hagan, Edward R. Howorka, Neena Jain
  • Patent number: 8516995
    Abstract: A method and apparatus for controlling a fuel pump assembly comprising a plurality of pump elements, each pump element comprising a cam-driven plunger to perform at least one pumping event per engine revolution and a control valve. Each pumping event corresponds to an associated cam lobe of the associated cam. The method comprises, for each pumping event of each pump element, controlling the control valve of said pump element in response to an output control signal derived from at least one previous pumping event. Fuel pressure is measured within a rail volume and compared with a demanded rail pressure value to derive a rail pressure error. A proportional term and an integral term for the rail pressure error are derived and combined to derive the output control signal. Monitoring of the integral term for each pumping event provides a means for identifying and diagnosing a fault condition.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: August 27, 2013
    Assignee: Delphi Technologies Holding S.arl
    Inventor: James Sinclair
  • Publication number: 20130207807
    Abstract: A fire detector includes a sensor (4) for, in use, detecting electromagnetic radiation emitted by a flame and generating an electronic signal corresponding to the detected electromagnetic radiation. The detector further includes a processing device (2) configured to select a portion of the electronic signal corresponding to a first time period and compare the selected signal portion with at least one parameter to determine an initial presence or absence of a flame, the processing device being further configured, upon determining the initial presence of the flame, to select a further portion of the electronic signal corresponding to a further time period and comparing the further selected signal portion with at least one parameter to determine a definite presence or absence of the flame.
    Type: Application
    Filed: May 10, 2011
    Publication date: August 15, 2013
    Inventor: James Sinclair Popper
  • Patent number: 8468975
    Abstract: Systems and methods for monitoring laboratory animals includes a tag comprising an inductive element and a capacitive element attached to a portion of a laboratory animal. The position of the portion is detected by monitoring the effect of the tag on a time-varying magnetic field having different frequencies, one near tag resonance, and one away from tag resonance.
    Type: Grant
    Filed: October 12, 2009
    Date of Patent: June 25, 2013
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Philip Salzmann, Trang Nguyen, James Sinclair
  • Patent number: 8397592
    Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: March 19, 2013
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: James Sinclair, B. Albert Griffin, Minh Vuong
  • Patent number: 8353969
    Abstract: Methods and devices for controlled evaporation of solvent from a solution are provided. In one embodiment, a method for controlled evaporation of solvent from at least one solution includes filling a selected first set of wells in a multi-well plate with a first solution comprising at least one first solvent. The method also includes attaching an inlet manifold to the plate, the inlet manifold comprising an inlet port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method further includes attaching an exhaust manifold to the plate, the exhaust manifold comprising an exhaust port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method also includes introducing a gas into the inlet port and removing solvent vapor from the selected first set of wells.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: January 15, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jack Barger, James Sinclair, Michael P. Emery