Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: Methods and compositions for treating cholangiocarcinoma.

Abstract: Compositions and methods for fetal or in utero delivery of active agents are provided. The compositions are most typically administered intravenously via the vitelline vein, umbilical vein, or directly into the amniotic cavity of a pregnant mother. Fibroblast growth factor is to correct structural defects of neural tissue.

Abstract: A lacrosse head removal and installation tool includes a generally cuboid body and a handle joined to the body. The body has a first end and a second end, sidewalls, and a c-shaped channel formed longitudinally through the body. The handle in joined to one of the sidewalls of the body midway between the first end and the second end.

Abstract: A marine survey system and method for ultrahigh resolution (UHR) mapping of a marine bottom (B) below a body of water (W) by means of a frame (20) towed as a whole by one or more towing cables (12) at a distance (Xf) behind a marine vessel (10) moving over the water (W) in a movement direction (V). The frame (20) comprises a rigid framework (23) and a plurality of independent acoustic sources (21), wherein each acoustic source (21) is independently controlled to emit a separate acoustic wave (A) propagating through the water (W) and reflecting off bottom regions of the marine bottom (B) for the mapping thereof. The acoustic sources (21) are kept fixated by the rigid framework (23) at a source-to-source distance (Ys) less than four meters in a transverse direction (Y) perpendicular to the movement direction (V) of the vessel (10) to distinguish the bottom regions with an ultrahigh resolution (Ry) of less than two meters at least in the transverse direction (Y).

Abstract: Methods and systems for pressure application are provided. A pressure application system comprises a base assembly having an upper profile and a lower profile, a chassis coupled to the base assembly, a ratchet, a handle coupled with the ratchet, and at least on strap retention mechanism coupled to the chassis. The ratchet extends through the chassis and least partially in the base assembly. The handle is coupled with the ratchet such that a movement of the handle moves the ratchet. The at least one strap retention mechanism is configured to receive a strap retention mechanism.

Abstract: A marine survey system and method for ultrahigh resolution (UHR) mapping of a marine bottom (B) below a body of water (W) by means of a frame (20) towed as a whole by one or more towing cables (12) at a distance (Xf) behind a marine vessel (10) moving over the water (W) in a movement direction (V). The frame (20) comprises a rigid framework (23) and a plurality of independent acoustic sources (21), wherein each acoustic source (21) is independently controlled to emit a separate acoustic wave (A) propagating through the water (W) and reflecting off bottom regions of the marine bottom (B) for the mapping thereof. The acoustic sources (21) are kept fixated by the rigid framework (23) at a source-to-source distance (Ys) less than four meters in a transverse direction (Y) perpendicular to the movement direction (V) of the vessel (10) to distinguish the bottom regions with an ultrahigh resolution (Ry) of less than two meters at least in the transverse direction (Y).

Abstract: Disclosed are techniques for traffic flow control. In an aspect, an on-board computer (OBC) of a vehicle of a secondary traffic flow determines that a primary traffic flow is passing through an intersection associated with a traffic light, wherein the determination that the primary traffic flow is passing through the intersection is based on sensor data from one or more sensors of the vehicle, vehicle-to-vehicle (V2V) communication, vehicle-to-everything (V2X) communication, or any combination thereof, and reduces a speed of the vehicle to prevent the vehicle from tripping a traffic light sensor associated with the traffic light until after the primary traffic flow has passed through the intersection.

Abstract: Novel RET fusion molecules and uses are disclosed.

Abstract: A system of object detection for a trailer. In one example, the system includes a camera configured to capture images of the trailer, where the images include an object other than the trailer. The system also includes a sensor configured to capture sensor data, a display configured to display images from the perspective of the camera, and a controller on the vehicle. The controller includes an electronic processor configured to receive the image data from the camera, receive the sensor data from the sensor, determine a blind spot, analyze the sensor data for radar data associated with the object, calculate the position of the object relative to the blind spot and the trailer, determine that the object is within the blind spot using an object detection algorithm, and in response to the determining that the object is within the blind spot, generate an augmented image.

Abstract: An improved computing tool performs an improved computing tool function to identify sensitive data risks in cloud-based deployments. A knowledge graph is built based on data schema information for a cloud-based computing environment, a set of parsed infrastructure logs, and a set of captured application queries. A set of sensitive flows in the knowledge graph are identified representing paths from a sensitive data element to an endpoint in the knowledge graph. The set of sensitive flows are scored based on a scoring algorithm and an alert is issued to an administrator in response to a score of a sensitive flow within the set of sensitive flows exceeding a threshold.

Abstract: A printed circuit board assembly comprises: a printed circuit board (PCB); an integrated circuit (IC) package that is mounted on the PCB and includes a first surface and a bare IC die disposed on the first surface; and a vapor chamber coupled to the first surface of the IC package.

Abstract: An apparatus for removably attaching manual equipment, which includes one wheel, to a power tow vehicle. The apparatus includes a cradle clamp head assembly; a vertical body assembly having a first end and an opposing second end, the cradle clamp head assembly configured to be attached to the vertical body assembly closer to the first end than the second end of the vertical body assembly; and a hitch receiver adapter configured to be attached to the vertical body assembly, while the cradle clamp head assembly is attached to the vertical body assembly, such that the hitch receiver adapter is further from the first end of the vertical body assembly than the cradle clamp head assembly.

Abstract: A method for detecting a marker in a body, comprising receiving an input signal from a probe, where the input signal is generated by a probe in response to detecting a marker signal from the marker; determining a marker proximity value based on the input signal, the marker proximity value corresponds to a distance between the probe and the marker; generating a feedback signal for output by a user interface device based on the marker proximity value, and outputting feedback signal, wherein range of the marker proximity value is divided into predetermined distance bands; and wherein at least one parameter of the feedback signal, or a rate of change of the at least one parameter of the feedback signal in relation to marker proximity value, is varied discontinuously at a boundary between at least two adjacent bands. The feedback signal may be an audio signal and/or a haptic signal.

Abstract: A method of analyzing a sample imaged by electron backscatter diffraction. The method comprises identifying a plurality of Kikuchi bands in an electron backscatter diffraction image of a position on the sample. The method further comprises forming, for each identified Kikuchi band, a respective vector representation of said Kikuchi band based at least in part on an estimate of the position on the sample. A configuration of the sample is determined by identifying a particular set of expected vector representations from a plurality of sets of expected vector representations as matching the vector representations of the plurality of identified Kikuchi bands.

Abstract: The present disclosure relates to techniques for segmenting tumors with positron emission tomography (PET) using deep convolutional neural networks for image and lesion metabolism analysis.

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

Abstract: A system and method for operating a rotatable knob module with adjustable tactile feedback. The rotatable knob module includes a knob configured to continuously rotate about a center axis and an electronic processor. The electronic processor is configured to determine a current trailer angle, define a virtual center position of the knob based on the current trailer angle, and adjust a rotational torque of the knob when the knob is rotated from a first rotational position to a second rotational position based on a relative virtual rotational distance of the second rotational position from the virtual center position.