Patents by Inventor James A. Swenberg

James A. Swenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOGA polynucleotides and polypeptides and uses thereof
    Patent number: 9102719
    Abstract: The present invention relates to the identification of polynucleotides and polypeptides involved in insulin and adiponectin signaling and regulation of glucose production. The invention further relates to the use of the identified polynucleotides and polypeptides, and inhibitors of the polynucleotides and polypeptides, in the regulation of glucose production and the monitoring and treatment of metabolic disorders such as diabetes.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: August 11, 2015
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Terry P. Combs, James A. Swenberg
  • SOGA Polynucleotides and Polypeptides and Uses Thereof
    Publication number: 20140134174
    Abstract: The present invention relates to the identification of polynucleotides and polypeptides involved in insulin and adiponectin signaling and regulation of glucose production. The invention further relates to the use of the identified polynucleotides and polypeptides, and inhibitors of the polynucleotides and polypeptides, in the regulation of glucose production and the monitoring and treatment of metabolic disorders such as diabetes.
    Type: Application
    Filed: September 6, 2013
    Publication date: May 15, 2014
    Applicant: University of North Carolina at Chapel Hill
    Inventors: Terry P. Combs, James A. Swenberg
  • SOGA polynucleotides and polypeptides and uses thereof
    Patent number: 8530174
    Abstract: The present invention relates to the identification of polynucleotides and polypeptides involved in insulin and adiponectin signaling and regulation of glucose production. The invention further relates to the use of the identified polynucleotides and polypeptides, and inhibitors of the polynucleotides and polypeptides, in the regulation of glucose production and the monitoring and treatment of metabolic disorders such as diabetes.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: September 10, 2013
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Terry P. Combs, James A. Swenberg
  • SOGA Polynucleotides and Polypeptides and Uses Thereof
    Publication number: 20120174243
    Abstract: The present invention relates to the identification of polynucleotides and polypeptides involved in insulin and adiponectin signaling and regulation of glucose production. The invention further relates to the use of the identified polynucleotides and polypeptides, and inhibitors of the polynucleotides and polypeptides, in the regulation of glucose production and the monitoring and treatment of metabolic disorders such as diabetes.
    Type: Application
    Filed: June 4, 2010
    Publication date: July 5, 2012
    Inventors: Terry P. Combs, James A. Swenberg
  • METHODS FOR DETECTION OF SINGLE STRAND BREAKS IN DNA
    Publication number: 20090233307
    Abstract: Methods are provided for detecting single strand breaks in DNA sample comprising: contacting the DNA with a neutral hydroxylamine, denaturing the DNA and detecting single strand breaks in the denatured DNA. Methods are also provided for the detecting single strand breaks in DNA from a cell, the methods comprising lysing the cell, denaturing the DNA from the lysed cell, wherein the DNA is contacted with a neutral hydroxylamine prior to and/or during the denaturing step and detecting single strand breaks in the DNA from the cell. In addition, methods are provided for distinguishing between true single strand breaks and artifactual single strand breaks resulting from cleaved alkaline labile sites.
    Type: Application
    Filed: March 16, 2009
    Publication date: September 17, 2009
    Inventors: Jun Nakamura, April Luke, James Swenberg
  • Method of detecting DNA single strand breaks
    Patent number: 6913878
    Abstract: A method of detecting increased levels of DNA single strand breaks in a eukaryotic cell sample, comprising the steps of: (a) contacting a eukaryotic cell sample to a water-soluble tetrazolium salt under conditions in which said tetrazolium salt is converted to a formazan dye in said cell sample in the presence of NADH or NADPH; and then (b) detecting the presence of the formazan dye in said cell sample, with decreased levels of the formazan dye indicating increased levels of DNA single strand breaks in the eukaryotic cell sample.
    Type: Grant
    Filed: January 6, 2003
    Date of Patent: July 5, 2005
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Jun Nakamura, James A. Swenberg
  • Method of detecting DNA single strand breaks
    Publication number: 20040132004
    Abstract: A method of detecting increased levels of DNA single strand breaks in a eukaryotic cell sample, comprising the steps of: (a) contacting a eukaryotic cell sample to a water-soluble tetrazolium salt under conditions in which said tetrazolium salt is converted to a formazan dye in said cell sample in the presence of NADH or NADPH; and then (b) detecting the presence of the formazan dye in said cell sample, with decreased levels of the formazan dye indicating increased levels of DNA single strand breaks in the eukaryotic cell sample.
    Type: Application
    Filed: January 6, 2003
    Publication date: July 8, 2004
    Inventors: Jun Nakamura, James A. Swenberg