Abstract: The present disclosure generally relates to methods and systems for engineering antibodies, and antigen-binding fragments thereof, to have altered characteristics. The present disclosure also provides a high-throughput method useful for identifying the engineered antibodies, or antigen-binding fragments thereof, that acquired the altered characteristics having performed the methods. These methods and systems have implications, for example, in the rapid development of biotherapeutics having desired and/or improved, e.g., affinity, specificity and/or activity-related, characteristics.

Abstract: A biodegradable and recyclable barrier paper laminate comprising an inorganic barrier layer against permeation.

Abstract: Methods for producing biodegradable and recyclable barrier paper laminate comprising an inorganic barrier layer against permeation.

Abstract: A reusable container system and method for reducing the use of plastic is disclosed herein. In one embodiment, a reusable container includes: a reusable bottle; a lid attachable to the reusable bottle that enables access removing and inserting single-use replaceable sealed bag or pouch; an inner single-use replaceable sealed bag or pouch that holds a liquid, viscous, or gel material inside the reusable bottle; a sprayer or pump attachable to the reusable bottle; and a dip tube with a leading edge that pierces the inner bag upon assembly of the above listed components. The liquid material is accessed for dispensing through the dip tube without contaminating the reusable bottle.

Abstract: A method of preventing or treating respiratory virus infections is provided. The method includes administering to a subject an effective amount of a composition comprising a homogeneous hypohalous acid solution that is free of hypochlorite in HOCL solutions and free of hypobromite in HOBr solutions. The hypohalous acid modifies surface receptor binding domains of virus surface proteins and inhibits their capacity to interact with host cell receptors.

Abstract: A styling device for hair, comprising protrusions, wherein the protrusions comprise a blend of a high molecular weight polyethylene oxide and a water insoluble polymer.

Abstract: Patterned fibrous substrates having a plurality of individual fibers, a first region, and a second region are provided. The first region is visually discernable from the second region. The first region has a first region fluid permeability score (PS1), and the second region has a second region fluid permeability score (PS2). The first region fluid permeability score (PS1) is different than the second region fluid permeability score (PS2). The first region fluid permeability score (PS1) and the second region fluid permeability score (PS2) are both greater than 5 Darcy.

Abstract: Patterned fibrous substrates having a plurality of individual fibers, a first region, and a second region are provided. The patterned fibrous substrates have a plurality of individual fibers of the first region having a first diameter and a plurality of individual fibers of the second region have a second diameter, wherein the first diameter is less than the second diameter. The individual fibers of the first region and the individual fibers of the second region are substantially free of bonds, other than primary bonds. The first region has a first C.I.E. L* score, and the second region has a second C.I.E. L* score, according to the Color Test Method. The first C.I.E. L* score is different than the second C.I.E. L* score.

Abstract: Patterned fibrous substrates having a plurality of individual fibers, a first region, and a second region are provided. The plurality of individual fibers comprise a functional surface additive. A plurality of individual fibers of the first region have a first diameter, and a plurality of individual fibers of the second region have a second diameter. The first diameter is less than the second diameter. The first region has a first C.I.E. L* score, and the second region has a second C.I.E. L* score. The first C.I.E. L* score is different than the second C.I.E. L* score.

Abstract: A hair cleaning implement in the form of a laminate with surface properties specifically tailored to improve sebum removal from hair. The implement includes a nonwoven material joined to a film to form a laminate and a plurality of discrete protrusions extending from the surface of the nonwoven material. The protrusions are configured to provide the desired surface properties to the implement.

Abstract: A method of neutralizing adverse biological effects of Interleukin 6 (IL-6) and other pro-inflammatory Interleukins in vivo is disclosed using homogeneous solutions of hypohalous acids to modify binding sites on cytokines and chemokines that are responsible for activation of cell surface receptors, and the initiation of harmful inflammatory processes or the growth of cytokine-dependent malignancies or of malignancies dependent on other chemical growth factors.

Abstract: The present disclosure provides methods and compositions of hypobromous acid for use in the treatment and prevention of inflammatory conditions, acute or chronic, of infectious or noninfectious origin, such as those attributable to hypersensitivity mechanisms or trauma in human subjects and animals. The disclosure in various embodiments provides compositions prepared at the time of need for such applications so as to contain pure hypobromous acid formed from stable precursor formulations containing oxidative chlorine in the form of hypochlorous acid, hypochlorite, or other forms of aqueous oxidative chlorine.

Abstract: A biodegradable and recyclable barrier paper laminate comprising an inorganic barrier layer against permeation.

Abstract: Methods for producing biodegradable and recyclable barrier paper laminate comprising an inorganic barrier layer against permeation.

Abstract: The computer case wireless charging apparatus enables charging wirelessly-chargeable external devices using a laptop battery, and includes a computer housing having a notebook computer, a notebook computer battery and USB ports; and a charging pad device connected to the computer housing. The charging pad device includes a charging pad housing enclosing an inductive charging coil. A small PCB is operably connected to the inductive charging coil, the notebook computer battery and the USB ports of the notebook computer. An optional soft outer protective sleeve may retain the computer housing. Portions of the apparatus may be made of materials including plastic, polylactic acid (PLA), silicon and combinations thereof. The inductive charging coil may be made of copper. The charging pad housing includes at least one charging surface for charging wirelessly-chargeable devices. The notebook computer housing may include a charging area constructed and arranged for receiving and retaining the charging pad housing.

Abstract: A reusable container system and method for reducing the use of plastic is disclosed herein. In one embodiment, a reusable container includes: a reusable bottle; a lid attachable to the reusable bottle that enables access removing and inserting single-use replaceable sealed bag or pouch; an inner single-use replaceable sealed bag or pouch that holds a liquid, viscous, or gel material inside the reusable bottle; a sprayer or pump attachable to the reusable bottle; and a dip tube with a leading edge that pierces the inner bag upon assembly of the above listed components. The liquid material is accessed for dispensing through the dip tube without contaminating the reusable bottle.

Abstract: Methods for true sterilization of an object, methods for inactivating an infectious protein, and methods for inactivating a microbial pathogen using a bufferless, electrolyzed, hypohalous acid composition.

Abstract: A hair cleaning implement in the form of a laminate with surface properties specifically tailored to improve sebum removal from hair. The implement includes a nonwoven material joined to a film to form a laminate and a plurality of discrete protrusions extending from the surface of the nonwoven material. The protrusions are configured to provide the desired surface properties to the implement.

Abstract: Methods for the inactivation of highly resistant infectious agents, on inanimate or epithelial surfaces or in suspension, upon exposure to aqueous solutions or gels containing hypohalous acids, and the use of these preparations in the treatment, prevention, and interruption of transmission of contagious diseases, particularly infections of oral and genital mucosal and mucocutaneous epithelial surfaces.

Abstract: A method of forming deformations in a nonwoven web includes the steps of: a) providing a precursor nonwoven web; b) providing a pair of forming members which include: a first forming member having a surface comprising a plurality of discrete, spaced apart male forming elements; and a second forming member having a surface comprising a plurality of recesses in the second forming member, wherein the recesses are aligned and configured to receive the male forming elements therein, wherein the recesses have a plan view periphery that is larger than, and may completely surround, the plan view periphery of the male elements; and c) mechanically deforming the precursor nonwoven web with the forming members by placing the precursor nonwoven web between the forming members. The method forms a nonwoven web having a generally planar first region and a plurality of discrete deformations.