Abstract: A patient interface includes a frame assembly including connectors operatively attachable to headgear, a cushion assembly provided to the frame assembly and including a seal-forming structure structured to form a seal with the patient's nose and/or mouth, and an air delivery connector provided to the frame assembly and operatively connected to an air delivery tube for supplying the air at positive pressure along an air flow path. The cushion assembly is structured to releasably connect to the frame assembly independently of the air delivery connector. The air delivery connector is structured to releasably connect to the frame assembly independently of the cushion assembly.

Abstract: This disclosure describes techniques and mechanisms for using a domain-specific language (DSL) to express and compile serverless network functions, and optimizing the deployment location for the serverless network functions on network devices. In some examples, the serverless network functions may be expressed entirely in the DSL (e.g., via a text-based editor, a graphics-based editor, etc.), where the DSL is a computer language specialized to a particular domain, such as a network function domain. In additional examples, the serverless network functions may be expressed and compiled using a DSL in combination with a general-purpose language (GSL). Once the serverless network function have been expressed and/or compiled, the techniques of this disclosure further include determining an optimized network component on which the serverless network function is to execute, and deploying the serverless function to the optimized network component.

Abstract: Techniques for creating consent contracts for devices that indicate whether the devices consent to receiving network-based communications from other devices. Further, the techniques include enforcing the consent contracts such that network-based communications are either allowed or disallowed in the network-communications layer prior to the network communications reaching the devices. Rather than simply allowing a device to communicate with any other device over a network, the techniques described herein include building in consent for network-based communications where the consent is consulted at one or more points in a communication process to make informed decisions about network-based traffic.

Abstract: Chemically induced dimerizers (AbCIDs) have emerged as one of the most powerful tools to artificially regulate signaling pathways in cells; however, no facile method to identify or design these systems currently exists. The present invention provides a methodology to rapidly generate antibody-based chemically induced dimerizers (AbCIDs) from known small-molecule-protein complexes by selecting for synthetic antibodies that recognize the chemical epitope created by the bound small molecule. Success of this strategy is demonstrated by generating ten chemically-inducible antibodies against the BCL-xL/ABT-737 complex. Three of the antibodies are highly selective for the BCL-xL/ABT-737 complex over BCL-xL alone. Two exemplary important cellular applications of AbCIDs are demonstrated by applying them intracellularly to induce CRISPRa-mediated gene expression and extracellularly to regulate CAR T-cell activation with the small molecule, ABT-737.

Abstract: In general, the present invention is directed to a metal-organic framework (MOF) for use in removing liquid phase compounds, in particular anionic and cationic species, as well as a combination of anionic and cationic species, from a liquid or liquid stream. In addition, the present invention is directed to various methods or processes for utilizing the MOF to remove such compounds from a liquid or liquid stream, such as an industrial process stream, and for using the MOF at elevated temperatures.

Abstract: A surface cleaning head may include a fluid distributor configured to distribute a cleaning fluid, an agitator configured to absorb at least a portion of the distributed cleaning fluid and to agitate debris on the surface to be cleaned, a fluid stripper configured to remove, from the agitator, at least a portion of the distributed cleaning fluid absorbed by the agitator, a debris container, and a removable cover. The debris container may include a solid debris chamber and a fluid debris chamber. The removable cover may include a fluid catch plate configured to transfer at least a portion of the cleaning fluid removed from the agitator by the fluid stripper to the fluid debris chamber, the fluid catch plate being configured to selectively transition between an in-use position and a cleaning position when the removable cover is removed from the surface cleaning head.

Abstract: Techniques for creating consent contracts for devices that indicate whether the devices consent to receiving network-based communications from other devices. Further, the techniques include enforcing the consent contracts such that network-based communications are either allowed or disallowed in the network-communications layer prior to the network communications reaching the devices. Rather than simply allowing a device to communicate with any other device over a network, the techniques described herein include building in consent for network-based communications where the consent is consulted at one or more points in a communication process to make informed decisions about network-based traffic.

Abstract: Examples described herein include systems and methods for dynamically determining a server for enrollment with a management system. An example method can include receiving user input at an application executing on a user device, such as a portal application that provides access to and authentication for other applications through a catalogue of application icons. If the user input includes a first URL but that URL produces an error when used in conjunction with extensions associated with a management server, the application can automatically use extensions associated with an application-support server. The application can then retrieve a second URL from the application-support server and use it for performing enrollment steps at the management server. The enrollment steps can include authenticating the user at an identity service and determining the user's group ID for enrollment, for example.

Abstract: The disclosure provides antibodies that specifically bind to a cleaved CDCP1 and antigen binding fragments thereof and methods of use thereof. In some aspects, the disclosure is directed to methods of treating a cancer in a subject, comprising administering to the subject an antibody or antigen-binding fragment thereof that specifically binds to a cleaved human CDCP1.

Abstract: The disclosure relates to radioimmunotherapy for bladder cancer using an antibody or antibody fragment that specifically binds CUB domain-containing protein 1 (CDCP1). The disclosure also relates to use of a diagnostic radioisotope-labeled anti-CDCP1 antibody or CDCP1-binding fragment thereof for radionuclide imaging of CDCP1 expression in vivo in bladder cancer patients.

Abstract: The disclosure relates to radioimmunotherapy for prostate cancer using an antibody or antibody fragment that specifically binds CUB domain-containing protein 1 (CDCP1). The disclosure further related to use of a diagnostic radioisotope-labeled anti-CDCP1 antibody or CDCP1-binding fragment thereof for radionuclide imaging of CDCP1 expression in vivo. in prostate cancer patients.

Abstract: Techniques for NAT-based steering of traffic in cloud-based networks. The techniques may include establishing, by a frontend node of a network, a connection with a client device. The frontend node may receive, via the connection, a packet including an indication of an identity of a service hosted on a backend node of the network. Based at least in part on the indication, the frontend node may establish a second connection with the backend node. Additionally, the frontend node may store a mapping indicating that packets received from the client device are to be sent to the backend node. The techniques may also include receiving another packet at the frontend node or another frontend node of the network. Based at least in part on the mapping, the frontend node or other frontend node may alter one or more network addresses of the other packet and forward it to the backend node.

Abstract: Anti-CD94 antibodies and their use are described.

Abstract: Circuitry for processing an analyte signal obtained from an electrochemical cell, the circuitry comprising: measurement circuitry having a first measurement input coupled to a first electrode of the electrochemical cell, the measurement circuitry configured to convert the analyte signal at the first measurement input to a first analog output signal; an analog-to-digital converter (ADC) having an first ADC input for receiving the first analog output signal, the ADC configured to convert the first analog output signal to a first digital output signal at an ADC output; compensation circuitry configured in a measurement mode to: apply a first compensation to the first digital output signal to obtain a first compensated digital output signal, the first compensation to compensate for non-linearity in the ADC; and apply a second compensation to the first compensated digital output signal to obtain a second compensated digital output signal, the second compensation to compensate for non-linearity in the measurement c

Abstract: Techniques for Network Address Translation (NAT)-based steering of traffic in cloud-based networks. The techniques may include establishing, by a frontend node of a network, a connection with a client device. The frontend node may receive, via the connection, a packet including an indication of an identity of a service hosted on a backend node of the network. Based at least in part on the indication, the frontend node may establish a second connection with the backend node. Additionally, the frontend node may store a mapping indicating that packets received from the client device are to be sent to the backend node. The techniques may also include receiving another packet at the frontend node or another frontend node of the network. Based at least in part on the mapping, the frontend node or other frontend node may alter one or more network addresses of the other packet and forward it to the backend node.

Abstract: Circuitry for processing an analyte signal obtained from an electrochemical cell, the circuitry comprising: a first signal path between a first electrode of the electrochemical cell and a first input of an analog-to-digital converter (ADC) circuit, the first signal path comprising a first gain stage configured to convert the analyte signal to a first analog signal; a second signal path between the first electrode and a second input of the ADC circuit, the second signal path comprising a second gain stage configured to convert the analyte signal to a second analog signal; and switching circuitry configured to selectively couple the first electrode to the first input of the ADC circuit.

Abstract: Circuitry for processing a response from an electrochemical cell to a stimulus, the circuitry comprising: sense circuitry configured to measure the response of the electrochemical cell to the stimulus; and processing circuitry configured to: sample the measured response to obtain a plurality of samples; and output the plurality of samples, wherein the processing circuitry is operable in: a continuous sampling mode in which the processing circuitry is configured to periodically sample the measured response at a fixed sampling rate; a discontinuous sampling mode in which the processing circuitry is configured to periodically sample the measured response during macro periods separated by macro intervals during which sampling of the measured response is disabled.

Abstract: Techniques and mechanisms to reduce double encryption of packets that are transmitted using encrypted tunnels. The techniques described herein include determining that portions of the packets are already encrypted, identifying portions of the packets that are unencrypted, and selectively encrypting the portions of the packets that are unencrypted prior to transmission through the encrypted tunnel. In this way, potentially private or sensitive data in the packets that is unencrypted, such as information in the packet headers, will be encrypted using the encryption protocol of the encrypted tunnel, but the data of the packets that is already encrypted, such as the payload, may avoid unnecessary double encryption. By reducing (or eliminating) the amount of data in data packets that is double encrypted, the amount of time taken by computing devices, and computing resources consumed, to encrypted traffic for encrypted tunnels may be reduced.

Abstract: A functional screen to rapidly identify antibodies that can activate NK cells is provided as well as antibodies identified in the screen and their use.

Abstract: Techniques for creating consent contracts for devices that indicate whether the devices consent to receiving network-based communications from other devices. Further, the techniques include enforcing the consent contracts such that network-based communications are either allowed or disallowed in the network-communications layer prior to the network communications reaching the devices. Rather than simply allowing a device to communicate with any other device over a network, the techniques described herein include building in consent for network-based communications where the consent is consulted at one or more points in a communication process to make informed decisions about network-based traffic.