Patents by Inventor James A. Wilkie

James A. Wilkie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240189495
    Abstract: The present disclosure provides methods of preparing an extracorporeal circuit for circulating blood. The methods of preparation include ascertaining the adsorptive potential of an anticoagulant to a filter membrane material and adjusting priming of the circuit in accordance.
    Type: Application
    Filed: April 8, 2022
    Publication date: June 13, 2024
    Inventors: James A. Wilkie, Lakhmir Chawla
  • Publication number: 20210369665
    Abstract: The present disclosure provides methods of treating a viral infection comprising administering a protease inhibitor, optionally conjointly with an anticoagulant therapy and/or antiviral agent.
    Type: Application
    Filed: May 25, 2021
    Publication date: December 2, 2021
    Inventors: James A. Wilkie, Lakhmir Chawla, Peter Jordan, Elaine C. Liong, Michelle M. Merrigan, Martha C. Farmer
  • Publication number: 20210353301
    Abstract: One aspect of the present invention provides a method for the treatment of lithiasis, which mitigates the risk of damage to surrounding body tissue when removing a calculi (e.g., biological concretions, such as urinary, biliary, and pancreatic stones) that obstructs or may otherwise be present within a body's anatomical lumen. In one embodiment, the instant invention provides a method of using a polymer plug to occlude a lumen distal to a calculi, whereby calculi fragments resulting from lithotripsy are prevented from traveling up the lumen. In certain embodiments, a dual lumen catheter is utilized to inject two solutions proximal to the calculi, the mixing of said solutions causing a polymer plug to form.
    Type: Application
    Filed: February 26, 2021
    Publication date: November 18, 2021
    Inventors: Jean-Marie Vogel, James A. Wilkie
  • Publication number: 20180117211
    Abstract: Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney. In certain embodiments, return of blood flow may be accelerated by cooling the kidney. The compositions, methods and kits for perfusive organ hemostasis can also be used to simplify or to enable other organ surgeries or interventional procedures, including liver surgery, prostate surgery, brain surgery, surgery of the uterus, spleen surgery and any surgery on any highly vascularized organs.
    Type: Application
    Filed: June 13, 2017
    Publication date: May 3, 2018
    Inventors: Jean-Marie Vogel, James A. Wilkie, Peter N. Madras
  • Publication number: 20170238938
    Abstract: One aspect of the present invention provides a method for the treatment of lithiasis, which mitigates the risk of damage to surrounding body tissue when removing a calculi (e.g., biological concretions, such as urinary, biliary, and pancreatic stones) that obstructs or may otherwise be present within a body's anatomical lumen. In one embodiment, the instant invention provides a method of using a polymer plug to occlude a lumen distal to a calculi, whereby calculi fragments resulting from lithotripsy are prevented from traveling up the lumen. In certain embodiments, a dual lumen catheter is utilized to inject two solutions proximal to the calculi, the mixing of said solutions causing a polymer plug to form.
    Type: Application
    Filed: September 30, 2016
    Publication date: August 24, 2017
    Inventors: Jean-Marie Vogel, James A. Wilkie
  • Publication number: 20170043050
    Abstract: Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney. In certain embodiments, return of blood flow may be accelerated by cooling the kidney. The compositions, methods and kits for perfusive organ hemostasis can also be used to simplify or to enable other organ surgeries or interventional procedures, including liver surgery, prostate surgery, brain surgery, surgery of the uterus, spleen surgery and any surgery on any highly vascularized organs.
    Type: Application
    Filed: March 18, 2016
    Publication date: February 16, 2017
    Inventors: Jean-Marie Vogel, James A. Wilkie, Peter N. Madras
  • Publication number: 20150018872
    Abstract: One aspect of the present invention relates to a method to control biological fluid flow at a site in a mammal by use of an in situ formed polymer plug. In certain embodiments, the present invention relates to a method to control bleeding following a catheterization procedure, a method to control leakage of cerebral spinal fluid following a lumbar puncture, a method to seal a fistula, or a method to control the flow of serous fluid after a lymphadenectomy. In certain embodiments, the polymer plug is generated in situ by temperature changes, pH changes or ionic interactions. In certain embodiments, the polymer plug comprises at least one optionally purified reverse thermosensitive polymer.
    Type: Application
    Filed: October 2, 2014
    Publication date: January 15, 2015
    Inventor: James A. Wilkie
  • Publication number: 20140205542
    Abstract: Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney. In certain embodiments, return of blood flow may be accelerated by cooling the kidney. The compositions, methods and kits for perfusive organ hemostasis can also be used to simplify or to enable other organ surgeries or interventional procedures, including liver surgery, prostate surgery, brain surgery, surgery of the uterus, spleen surgery and any surgery on any highly vascularized organs.
    Type: Application
    Filed: March 25, 2014
    Publication date: July 24, 2014
    Applicants: Lahey Clinic, Inc., Genzyme Corporation
    Inventors: Jean-Marie Vogel, James A. Wilkie, Peter N. Madras
  • Publication number: 20080208163
    Abstract: One aspect of the present invention relates to a method to control biological fluid flow at a site in a mammal by use of an in situ formed polymer plug. In certain embodiments, the present invention relates to a method to control bleeding following a catheterization procedure, a method to control leakage of cerebral spinal fluid following a lumbar puncture, a method to seal a fistula, or a method to control the flow of serous fluid after a lymphadenectomy. In certain embodiments, the polymer plug is generated in situ by temperature changes, pH changes or ionic interactions. In certain embodiments, the polymer plug comprises at least one optionally purified reverse thermosensitive polymer.
    Type: Application
    Filed: February 22, 2008
    Publication date: August 28, 2008
    Applicant: Pluromed, Inc.
    Inventor: James A. Wilkie
  • Publication number: 20080181952
    Abstract: Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney. In certain embodiments, return of blood flow may be accelerated by cooling the kidney. The compositions, methods and kits for perfusive organ hemostasis can also be used to simplify or to enable other organ surgeries or interventional procedures, including liver surgery, prostate surgery, brain surgery, surgery of the uterus, spleen surgery and any surgery on any highly vascularized organs.
    Type: Application
    Filed: December 11, 2007
    Publication date: July 31, 2008
    Applicants: Pluromed, Inc., Lahey Clinic, Inc.
    Inventors: Jean-Marie Vogel, James A. Wilkie, Peter N. Madras
  • Patent number: 6368300
    Abstract: An apparatus and method apply a hemostatic agent onto a tissue. The apparatus includes a tube having a first end and a second end. A lumen of the tube is tapered from the first end to the second end. A hemostatic agent source is within the tube. A plunger is included for directing the hemostatic agent from the tapered tube through an opening at the second end. The hemostatic agent can be directed from the tube through the opening of the second end onto the tissue.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: April 9, 2002
    Assignee: C. R. Bard, Inc.
    Inventors: Timothy J. Fallon, John G. Maresh, James A. Wilkie
  • Patent number: 6027471
    Abstract: An apparatus and method apply a hemostatic agent onto a tissue. The apparatus includes a tube having a first end and a second end. A lumen of the tube is tapered from the first end to the second end. A hemostatic agent source is within the tube. A plunger is included for directing the hemostatic agent from the tapered tube through an opening at the second end. The hemostatic agent can be directed from the tube through the opening of the second end onto the tissue.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: February 22, 2000
    Inventors: Timothy J. Fallon, John G. Maresh, James A. Wilkie