Abstract: Systems and methods for delivering targeted neurostimulation therapies to the nervous system of a subject are provided. A set of electrodes can be strategically distributed around a target nerve, and the nerve can be activated though the electrodes using a channel-hopping interleaved pulse scheduling (CHIPS) stimulation strategy. The systems and methods can leverage the spatiotemporal summation of short, sub-threshold current pulses interleaved across two or more independent stimulation channels (hopping from channel to channel) and delivered across electrodes strategically placed in an interfering configuration around the target neural tissue.

Abstract: Systems and methods for delivering targeted neurostimulation therapies to the nervous system of a subject are provided. A set of electrodes can be strategically distributed around a target nerve, and the nerve can be activated though the electrodes using a channel-hopping interleaved pulse scheduling (CHIPS) stimulation strategy. The systems and methods can leverage the spatiotemporal summation of short, sub-threshold current pulses interleaved across two or more independent stimulation channels (hopping from channel to channel) and delivered across electrodes strategically placed in an interfering configuration around the target neural tissue.

Abstract: Disclosed herein is a non-invasive intraoral neurostimulation device and method for treating obstructive sleep apnea (OSA) while improving adherence, effectiveness, and outcomes. The intraoral neurostimulation device includes a mouthpiece, at least one electrode pair having a reference electrode and a stimulating electrode supported by the mouthpiece, and a substrate positioned between a tongue of a user and the stimulating electrode. The intraoral neurostimulation device is configured to deliver non-invasive electrical neurostimulation to the motor neurons of at least one genioglossus muscle to induce a muscle contraction of the tongue, thereby eliminating the blockage and returning normal airflow to the user. In certain embodiments, the intraoral neurostimulation device is paired with a respiratory sensor to deliver stimulation synchronized with the respiratory rhythm of the user or deliver stimulation only during apneic episodes, reducing the total amount of stimulation time.

Abstract: Devices, systems, and methods for recording action potential (AP) from a nerve are provided. A device can include a cuff or a microchannel to be used to record an AP from a nerve. A recording electrode can be included within a channel of the cuff or microchannel, and the recording electrode can be offset or off-center such that it is not located mid-channel within the recording cuff or microchannel.

Abstract: Systems and methods for providing orientation data to a user during a medical procedure performed on a subject are provided. The system can include a medical device, an electrical component and a display device. The medical device is configured to engage a portion the subject and includes a handle. The electrical component is disposed within the handle and is configured to generate data related to an orientation of the medical device during the medical procedure. The display device is physically separate from the medical device and in communication the electrical component. The display device also includes a processor configured to receive and process the data related to the orientation of the medical device, and display information related to the orientation of the medical device to the user based on the data.

Abstract: Devices, systems, and methods for recording action potential (AP) from a nerve are provided. A device can include a cuff or a microchannel to be used to record an AP from a nerve. A recording electrode can be included within a channel of the cuff or microchannel, and the recording electrode can be offset or off-center such that it is not located mid-channel within the recording cuff or microchannel.

Abstract: Embodiments of a resistive microcracked pressure sensor having a metal stack with a metallic conductor encapsulated within an elastomer substrate and related method of manufacture are disclosed. During manufacture, the metallic conductor forms a plurality of microcracks that increase the overall resistance of the metallic conductor. The microcracks in the metallic conductor allow greater magnitudes of normal and shear forces to be applied to the pressure sensor without fracturing metallic conductor.

Abstract: A device and methods for performing a closed-chain exercise for the lower extremities of a human subject and, in particular, the legs, using stimulation. The device may include a sled for receiving the subject and for translating to and fro between a first, lower position in which the legs are at least partially bent and a second, higher position in which the legs are less bent than in the first position. A stimulator is provided for facilitating the performance of the closed-chain leg exercise by the subject to move the sled between the first and second positions, either by way of electrical signals provided directly to the applicable muscles or by way of sensory (e.g., visual) stimulation, with or without electro-muscular stimulation. In another aspect, adaptive feed-forward control may also be used to enhance the exercise regimen performed using the device.