Patents by Inventor James Abraham

James Abraham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stereoselective process for producing intermediates of cryptophycins
    Patent number: 6376230
    Abstract: This invention provides processes for preparing intermediates useful for the preparation of cryptophycin compounds.
    Type: Grant
    Filed: October 8, 1999
    Date of Patent: April 23, 2002
    Assignee: Eli Lilly and Company
    Inventors: James Abraham Aikins, Barbara Shreve Briggs, Tony Yantao Zhang, Milton Joseph Zmijewski, Jr.
  • Optical resolution of aminoisobobutyric acid
    Patent number: 6372936
    Abstract: A process for resolving amino protected racemic 3-amino-2-methylpropionic acid which comprises the steps of: (1) reacting said amino protected acid with a protected amino group with an enantiomer of a chiral amine to form diastereomeric salts; (2) recrystallizing the diastereomeric salts from ethyl acetate to separate the diastereomeric salts into crystal fractions; and (3) releasing the resolved acid from the diastereomeric salt by treating the diastereomeric salt with a basic solution is disclosed. A process for the preparation of the cryptophycin molecules is also disclosed.
    Type: Grant
    Filed: May 8, 2000
    Date of Patent: April 16, 2002
    Assignee: Eli Lilly and Company
    Inventors: James Abraham Aikins, Tony Yantao Zhang