Patents by Inventor James Adam Hendricks

James Adam Hendricks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Photoswitchable HDAC inhibitors
    Patent number: 11596691
    Abstract: This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: March 7, 2023
    Assignee: The General Hospital Corporation
    Inventors: Ralph Mazitschek, Balaram Ghosh, James Adam Hendricks, Surya Reis, Stephen John Haggarty
  • Photoswitchable HDAC Inhibitors
    Publication number: 20210162048
    Abstract: This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same.
    Type: Application
    Filed: November 6, 2020
    Publication date: June 3, 2021
    Inventors: Ralph Mazitschek, Balaram Ghosh, James Adam Hendricks, Surya Reis, Stephen John Haggarty
  • Photoswitchable HDAC inhibitors
    Patent number: 10828367
    Abstract: This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: November 10, 2020
    Assignee: The General Hospital Corporation
    Inventors: Ralph Mazitschek, Balaram Ghosh, James Adam Hendricks, Surya Reis, Stephen John Haggarty
  • BODIPY dyes for biological imaging
    Patent number: 10696695
    Abstract: This invention relates to water-soluble mono-alkoxy and mono-alkyne BODIPY derivatives, including methods for making the same. For examples, provided herein are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: is a BODIPY ligand system; X is a halogen; L is absent or a linker; and Z is selected from the group consisting of: a group reactive with a biologically active molecule and a detectable agent.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: June 30, 2020
    Assignee: The General Hospital Corporation
    Inventors: Ralph Mazitschek, Alexandra M. Courtis, James Adam Hendricks
  • BODIPY DYES FOR BIOLOGICAL IMAGING
    Publication number: 20190127394
    Abstract: This invention relates to water-soluble mono-alkoxy and mono-alkyne BODIPY derivatives, including methods for making the same. For examples, provided herein are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: is a BODIPY ligand system; X is a halogen; L is absent or a linker; and Z is selected from the group consisting of: a group reactive with a biologically active molecule and a detectable agent.
    Type: Application
    Filed: June 25, 2018
    Publication date: May 2, 2019
    Inventors: Ralph Mazitschek, Alexandra M. Courtis, James Adam Hendricks
  • Photoswitchable HDAC Inhibitors
    Publication number: 20190070295
    Abstract: This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same.
    Type: Application
    Filed: May 1, 2018
    Publication date: March 7, 2019
    Inventors: Ralph Mazitschek, Balaram Ghosh, James Adam Hendricks, Surya Reis, Stephen John Haggarty
  • Bodipy dyes for biological imaging
    Patent number: 10005793
    Abstract: This invention relates to water-soluble mono-alkoxy and mono-alkyne BODIPY derivatives, including methods for making the same. For examples, provided herein are compounds of Formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein: (a) is a BODIPY ligand system; X is a halogen; L is absent or a linker; and Z is selected from the group consisting of: a group reactive with a biologically active molecule and a detectable agent.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: June 26, 2018
    Assignee: The General Hospital Corporation
    Inventors: Ralph Mazitschek, Alexandra M. Courtis, James Adam Hendricks
  • Photoswitchable HDAC inhibitors
    Patent number: 9981038
    Abstract: This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same. Provided herein are inhibitors of HDAC having photoswitchable modulators of protein function with short thermal relaxation kinetics. The compounds are diazo compounds including a substituted or unsubstituted aryl or heteroaryl ring, wherein at least one of the rings is substituted with one or more HDAC targeting elements.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 29, 2018
    Assignee: The General Hospital Corporation
    Inventors: Ralph Mazitschek, Balaram Ghosh, James Adam Hendricks, Surya Reis, Stephen John Haggarty
  • Photoswitchable HDAC Inhibitors
    Publication number: 20160022817
    Abstract: This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same. Provided herein are inhibitors of HDAC having photoswitchable modulators of protein function with short thermal relaxation kinetics. The compounds are diazo compounds including a substituted or unsubstituted aryl or heteroaryl ring, wherein at least one of the rings is substituted with one or more HDAC targeting elements.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 28, 2016
    Applicant: The General Hospital Corporation
    Inventors: Ralph Mazitschek, Balaram Ghosh, James Adam Hendricks, Surya Reis, Stephen John Haggarty
  • BODIPY DYES FOR BIOLOGICAL IMAGING
    Publication number: 20150252061
    Abstract: This invention relates to water-soluble mono-alkoxy and mono-alkyne BODIPY derivatives, including methods for a making the same. For examples, provided herein are compounds of Formula (I): (I) or a pharmaceutically acceptable salt thereof wherein: (a) is a BOD1PY ligand system; X is a halogen; L is absent or a linker; and Z is selected from the group consisting of: a group reactive with a biologically active molecule and a detectable agent.
    Type: Application
    Filed: October 1, 2013
    Publication date: September 10, 2015
    Applicant: The General Hospital Corporation
    Inventors: Ralph Mazitschek, Alexandra M. Courtis, James Adam Hendricks