Patents by Inventor James Alfano

James Alfano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080083523
    Abstract: A temperature control device is disclosed for a metering head of a paper machine. The control device includes a metering head fabrication, the fabrication defining an internal cavity. In use of the metering head, the cavity is filled with a liquid. A displacement tube is disposed within and extends along the cavity for optimizing a flow of the liquid along the boundaries of the cavity for permitting accurate temperature control of the metering head.
    Type: Application
    Filed: May 7, 2007
    Publication date: April 10, 2008
    Inventors: James Alfano, Brian George
  • Publication number: 20080028487
    Abstract: The bacterial plant pathogen Pseudomonas syringae injects effector proteins into host cells via a type III protein secretion system to cause disease. The invention relates to the discovery that the type III effector HopU1 is a mono-ADP-ribosyltransferase (ADP-RT) and suppresses plant innate immunity. The HopU1 substrates in Arabidopsis thaliana extracts were RNA-binding proteins that possess RNA-recognition motifs (RRMs). A. thaliana knock-out lines defective in the glycine-rich RNA-binding protein AtGRP7, a HopU1 substrate, were more susceptible than wild type plants to P. syringae. The ADP-ribosylation of AtGRP7 by HopU1 required two arginines within the RRM. The invention provides novel methods for the modulation of the innate immune response of a plant to a biotic stress, including methods for enhancing or suppressing the innate immune response of the plant.
    Type: Application
    Filed: June 6, 2007
    Publication date: January 31, 2008
    Applicant: THE UNIVERSITY OF NEBRASKA-LINCOLN
    Inventors: JAMES ALFANO, ZHENG QING FU, THOMAS ELTHON
  • Publication number: 20070214984
    Abstract: A rod holder device is disclosed for holding a rod in a metering head of a size press. The rod holder device includes an elongate rod holder having a tending side and a back side and a front and a back face, the rod holder defining a cavity for the removable reception therein of the rod, the cavity extending between the sides of the rod holder. The rod holder defines an extension which extends between the sides of the rod holder. The extension has a proximal and a distal end and a first and a second surface, the distal end of the extension defining a plurality of spaced notches. A clamping plate has a first and a second extremity and a first and a second edge and a first a and a second face, the clamping plate being secured to the metering head. The clamping plate defines a plurality of spaced recesses.
    Type: Application
    Filed: March 20, 2007
    Publication date: September 20, 2007
    Inventors: James Alfano, Roger Goecks
  • Publication number: 20070162994
    Abstract: One aspect of the present invention relates to isolated nucleic acid molecules encoding avirulence proteins or polypeptides of Pseudomonas syringae pv. syringae DC 3000, or nucleic acid molecules which are complementary thereto. Expression vectors, host cells, and transgenic plants which include the DNA molecules of the present invention are also disclosed. Another aspect relates to the isolated proteins or polypeptides and compositions containing the same. The various nucleic acid molecules and proteins of the present invention can be used to impart disease resistance to a plant, make a plant hypersusceptible to colonization by nonpathogenic bacteria, modify a metabolic pathway in a cell, cause eukaryotic cell death and treat a cancerous condition, as well as inhibit programmed cell death.
    Type: Application
    Filed: December 27, 2006
    Publication date: July 12, 2007
    Inventors: Alan Collmer, James Alfano, Samuel Cartinhour, David Schneider, Xiaoyan Tang
  • Publication number: 20050039232
    Abstract: One aspect of the present invention relates to isolated nucleic acid molecules (i) encoding proteins or polypeptides of Pseudomonas CEL and EEL genomic regions, (ii) nucleic acid molecules which hybridize thereto under stringent conditions, or (iii) nucleic acid molecules that include a nucleotide sequence which is complementary to the nucleic acid molecules of (i) and (ii). Expression vectors, host cells, and transgenic plants which include the DNA molecules of the present invention are also disclosed. Another aspect relates to the isolated proteins or polypeptides and compositions containing the same. The nucleic acid molecules and proteins of the present invention can be used to imparting disease resistance to a plant, making a plant hypersusceptible to colonization by nonpathogenic bacteria, causing eukaryotic cell death, and treating cancerous conditions.
    Type: Application
    Filed: July 16, 2004
    Publication date: February 17, 2005
    Inventors: Alan Collmer, James Alfano, Amy Charkowski