Patents by Inventor James Allay

James Allay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vivo selection of primitive hematopoietic cells
    Patent number: 6500421
    Abstract: The invention is directed to a method of in vivo selection for genetically modified hematopoietic progenitor cells from nonmodified hematopoietic cells in a subject. Ibis goal is accomplished by introducing mutant dihydrofolate reductase genes into hematopoietic progenitor cells and then administering to a subject harboring the resultant transformed cells an antifolate and a nucleoside transport inhibitor. The invention is also directed to nucleic acids encoding mutant dihydrofolate reductase genes and to hematopoietic cells transformed with such mutant genes.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: December 31, 2002
    Assignee: St. Jude Children's Research Hospital
    Inventors: Brian P. Sorrentino, Raymond L. Blakely, James Allay, H. Trent Spencer