Abstract: A crusher for cylindrical core samples has two oscillating wear plates. Each wear plate has an angled introductory portion, which open to a mouth sufficiently large to receive core samples having diameter above 100 mm. Each wear plate has at least one intermediate surface extending between each angled introductory portion and a curved central portion of the wear plate.

Abstract: A control system and method which automatically responds to a stalling motor due to a brush head binding or hanging event, and which automatically prevents backlash damage to the electronics when the brush head is freed from it's constraints.

Abstract: A positive displacement gear pump or gear hydraulic motor having at least a first rotor with first rotor teeth and a second rotor with second rotor teeth, the first rotor teeth meshing with the second rotor teeth. First rotor chambers are defined between first rotor teeth and second rotor chambers are defined between the second rotor teeth. As the rotors mesh, the first rotor chambers, second rotor chambers or both become enclosed or substantially enclosed to form what are referred to here as secondary chambers. Pressure variations in a secondary chamber are relieved by internal flow channels in the first rotor, second rotor or both, creating a fluid connection between the first rotor chambers and the second rotor chambers. The first rotor may be an internal gear rotor or both rotors may be external gear rotors.

Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising an glutathione alkyl ester, adduct thereof, or pharmaceutically acceptable salt, tautomer, or solvate thereof.

Abstract: The invention is for liners provided for use in a flush toilet with an interior. The liners are configured to fit within the interior area of the toilet bowl to contact an upper surface of the toilet water. The liners prevent soiling of the interior of the toilet bowl and facilitate the efficient removal and flushing of human waste. The liner acts as a barrier between the toilet bowl and wastewater, whereby the liner can then be flushed along with the contents of the bowl, thereby extending the period between necessary cleanings.

Abstract: This document relates to methods and materials for making and using viruses (e.g., measles viruses or adenoviruses) having a reduced susceptibility to antibody neutralization (e.g., antibody neutralization by serum from measles virus vaccines). For example, recombinant morbilliviruses (e.g., recombinant measles viruses) having a modified H gene and a modified F gene, as well as methods of using a recombinant virus are provided.

Abstract: Among other things, there is disclosed structure and methods for maintaining access to a location in the body while reducing or eliminating the potential for pulling an access device (e.g. a catheter) back through an opening. An introducer sheath includes a distal indented portion and a balloon, so that once placed in a desired location through tissue, the balloon can be inflated to anchor the sheath against retraction. In particular embodiments, structure and methods for accessing the pericardial cavity via the right atrial appendage are shown.

Abstract: Drill guides are disclosed herein that include a tapered projection that hooks under a bone to position the drill guide relative to the bone. The drill guide is used to drill a hole that receives a suture anchor.

Abstract: Dressing or bandage for protecting a wound accidentally incurred, surgical incision deliberately made in the skin, epidermal delivery of medication, or musculotherapy of a human being or animal, said bandage/dressing having the primary characteristic of being significantly atraumatic upon removal of same by virtue of a novel stringlike member that is intentionally incorporated into or debossed into the construction of said parent bandage/dressing in a multi-spiral geometry, said stringlike member firstly being pulled gently and progressively in multiple turns around the wound site or epidermal treatment area to in effect significantly reduce the area of remaining/undisturbed adhesive between the bandage/dressing and patient's skin before the bandage/dressing is peeled away from the skin in conventional manner and thus affording the patient a significantly less traumatic experience.

Abstract: Disclosed are novel means of enhancing mesenchymal stem cell regenerative activities including, intra alia, production from pulmonary leakage and suppression of scar tissue formation by co-administration with T regulatory cells. In some embodiments the invention provides an interaction between T regulatory cells and mesenchymal stem cells in which T regulatory cells stimulate upregulation of mesenchymal stem cell activity in a GITR dependent manner.

Abstract: An orthopaedic joint replacement system is shown and described. The system includes a number of prosthetic components configured to be implanted into a patient's knee. The system also includes a number of surgical instruments configured for use in preparing the bones of the patient's knee to receive the implants. A method or technique for using the surgical instruments to prepare the bones is also disclosed.

Abstract: Methods are provided for treating or preventing human immunodeficiency virus-1 (HIV-1) or human immunodeficiency virus-2 (HIV-2) in a virologically suppressed patient in need thereof comprising switching the patient from an antiretroviral treatment regimen comprising at least three antiretroviral agents to a treatment regimen comprising only two antiretroviral agents. In one aspect the two treatment regimen consists of dolutegravir, rilpivirine and at least one pharmaceutically acceptable excipient, diluent or carrier. In another aspect of the invention, there is provided a multilayer tablet comprising dolutegravir or a pharmaceutically acceptable salt thereof and rilpivirine or a pharmaceutically acceptable salt thereof.

Abstract: A mounting bracket for a prosthetic foot configured to attach to a residual limb, comprising an upper member, a lower member and compression torsion joint. The upper member comprises an upper flange, a mating post, and mounting portion configured to attach to the residual limb. The lower member comprises a mating portion, a lower flange, and a mounting portion configured to attach to the prosthetic foot. The compression torsion joint couples the upper member to the lower member and is configured to limit the vertical movement and torsional movement of the upper member with respect to the lower member.

Abstract: A multi lumen catheter assembly. The assembly provides an expandable, low profile, fixed length sheath and catheter, with fixed infusion ports. The assembly has an expandable outer sheath that expands upon pressure activation with a fluid and the sheath allows the fluid to exit from at least one predetermined fixed location from a distal end of the catheter assembly. The catheter assembly can be used in various medical device procedures, such as a TIPS (Transjugular Intrahepatic Portosystemic Shunt) procedure, or anywhere a low profile, multi lumen, infusion catheter system is desired.

Abstract: Methods and systems for intraoperatively determining alignment parameters of a spine during a spinal surgical procedure are disclosed herein. In some embodiments, a method of intraoperatively determining an alignment parameter of a spine during a surgical procedure includes receiving initial image data of the spine including multiple vertebrae and identifying a geometric feature associated with each vertebra in the initial image data. The geometric features each have a pose in the initial image data and characterize a three-dimensional (3D) shape of the associated vertebra. The method further comprises receiving intraoperative image data of the spine and registering the initial image data to the intraoperative image data. The method can then update the pose of each geometric feature based on the registration and the intraoperative image data, and determine the alignment parameter based on the updated poses of the geometric features associated with two or more of the vertebrae.

Abstract: Systems, devices, and methods to accurately and precisely align a visualized axis with one or more objects in an image field during a procedure using an imager based positioner system attached to an electronic positioning device are described. Specific methods of implanting guide pins into a first pedicle and a second pedicle of a vertebrae of a patient through a lumen of a trocar to a target of interest are also described.

Abstract: A system for monitoring and detecting the gait and other health related parameters of a user. One such parameter is monitoring of medication compliance and treatment session attendance done by a medication and liquid dispensing apparatus, which combines mechanical dispensing of medication. These parameters are provided in standard of care summaries to care providers, and are continually reported by the Optimum Recognition Blueprint as Standard of Care Summaries to care providers, as well as communicated to the end-user by the Virtual Caregiver Interface.

Abstract: The present disclosure relates to systems and methods to perform a surgical procedure. The systems and methods utilize MRI-compatible fiducial markers including a body having at least one feature configured to receive an MRI-compatible and MRI-visible material and to allow registration of a navigational tool. The MRI-compatible fiducial markers can be affixed to a bone of a patient. The registered navigational tool can be used to advance a surgical tool along a navigational path to perform a surgical procedure.

Abstract: A side dam for a continuous metal casting apparatus includes an insulator and a belt system having an endless belt. The endless belt includes a belt surface, and the endless belt is movable relative to the insulator such that a portion of the belt surface is configured to face a casting cavity of the continuous metal casting apparatus as the endless belt is moved. In some examples, the endless belt is movable in a plane of motion that is perpendicular to the belt surface.

Abstract: Disclosed is a system and method for regulating tourniquet cuff pressure to restrict blood flow penetration past the cuff based on a personalized restrictive pressure (PRP). The system includes mechanisms for estimating a limb occlusion pressure (LOP) by determining a minimum pressure at which arterial blood penetration past an applied tourniquet cuff is stopped and measuring a pulsation characteristic associated with the LOP. Thereafter, the system establishes a PRP by determining a second pressure that restricts but does not stop arterial blood penetration past the cuff and that corresponds to a second pulsation characteristic differing by a percentage from the pulsation characteristic associated with the LOP. During a limb-activity time period, the system maintains pressure in the applied tourniquet cuff near the PRP, thereby restricting but not stopping arterial blood penetration past the cuff during the activity time period.