Abstract: A system advances loans secured by healthcare claims based on clinical and financial information associated with the claims. A loan advance system employs healthcare claim information related to provision of healthcare to patients. The system includes a data acquisition processor for acquiring clinically related information associated with a healthcare claim of a patient. A loan advance processor determines a portion of the claim total amount to be advanced as a loan to a healthcare provider organization, in response to the clinically related information associated with the claim and prior to evaluation of the claim by a claim payor organization.