Patents by Inventor James Arthur Hoffmann

James Arthur Hoffmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7563763
    Abstract: This invention relates to FSH or a FSH variant containing an alpha and beta subunit contained in formulations, and articles of manufacture. The invention provides advantageous new proteins and nucleic acids, multi-use pharmaceutical solutions, formulations and products of said proteins and nucleic acids where none approved for commercial use had previously existed having such extended use indications. These products are particularly useful in therapeutic regimens for increasing serum levels of FSH or a FSH variant over a period of treatment. Thus, inter alia, the invention fills the need for convenient products of FSH or from a FSH variant.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: July 21, 2009
    Assignee: Ares Trading S.A.
    Inventors: James Arthur Hoffmann, Jirong Lu
  • Patent number: 7446090
    Abstract: This invention relates to FSH or a FSH variant containing an alpha and beta subunit contained in formulations, and articles of manufacture. The invention provides advantageous new proteins and nucleic acids, multi-use pharmaceutical solutions, formulations and products of said proteins and nucleic acids where none approved for commercial use had previously existed having such extended use indications. These products are particularly useful in therapeutic regimens for increasing serum levels of FSH or a FSH variant over a period of treatment. Thus, inter alia, the invention fills the need for convenient products of FSH or from a FSH variant.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: November 4, 2008
    Assignee: Ares Trading S.A.
    Inventors: James Arthur Hoffmann, Jirong Lu
  • Publication number: 20080051329
    Abstract: This invention relates to FSH or a FSH variant containing an alpha and beta subunit contained in formulations, and articles of manufacture. The invention provides advantageous new proteins and nucleic acids, multi-use pharmaceutical solutions, formulations and products of said proteins and nucleic acids where none approved for commercial use had previously existed having such extended use indications. These products are particularly useful in therapeutic regimens for increasing serum levels of FSH or a FSH variant over a period of treatment.
    Type: Application
    Filed: August 26, 2005
    Publication date: February 28, 2008
    Inventors: James Arthur Hoffmann, Jirong Lu
  • Publication number: 20030166525
    Abstract: This invention relates to FSH or a FSH variant containing an alpha and beta subunit contained in formulations, and articles of manufacture. The invention provides advantageous new proteins and nucleic acids, multi-use pharmaceutical solutions, formulations and products of said proteins and nucleic acids where none approved for commercial use had previously existed having such extended use indications. These products are particularly useful in therapeutic regimens for increasing serum levels of FSH or a FSH variant over a period of treatment. Thus, inter alia, the invention fills the need for convenient products of FSH or from a FSH variant.
    Type: Application
    Filed: August 10, 2001
    Publication date: September 4, 2003
    Inventors: James Arthur Hoffmann, Jirong Lu
  • Patent number: 6555521
    Abstract: The invention provides individual tetragonal flat rod shaped or plate-like crystals of glucagon-like peptide-1 related molecules, processes for their preparation, compositions and methods of use. The crystal preparations exhibit extended time action in vivo and are useful for treating diabetes, obesity and related conditions.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: April 29, 2003
    Assignee: Eli Lilly and Company
    Inventors: Ronald Norbert Hermeling, James Arthur Hoffmann, Chakravarthy Narasimhan
  • Publication number: 20030045464
    Abstract: The invention provides individual tetragonal flat rod shaped or plate-like crystals of glucagon-like peptide-1 related molecules, processes for their preparation, compositions and methods of use. The crystal preparations exhibit extended time action in vivo and are useful for treating diabetes, obesity and related conditions.
    Type: Application
    Filed: November 30, 2001
    Publication date: March 6, 2003
    Inventors: Ronald Norbert Hermeling, James Arthur Hoffmann, Chakravarthy Narasimhan
  • Publication number: 20020123466
    Abstract: Methods and formulations are presented that provide for a) the oral absorption of GLP-1 peptides that bind surfactants; and b) long-term storage of formulations containing these peptides. For example, a GLP-1/DSS complex is administered orally instead of parenterally, which is much more convenient for, and facilitates compliance with diabetic patients and persons with other GLP-1 treated conditions.
    Type: Application
    Filed: February 8, 2002
    Publication date: September 5, 2002
    Inventor: James Arthur Hoffmann
  • Patent number: 6380357
    Abstract: The invention provides individual tetragonal flat rod shaped or plate-like crystals of glucagon-like peptide-1 related molecules, processes for their preparation, compositions and methods of use. The crystal preparations exhibit extended time action in vivo and are useful for treating diabetes, obesity and related conditions.
    Type: Grant
    Filed: December 11, 1998
    Date of Patent: April 30, 2002
    Assignee: Eli Lilly and Company
    Inventors: Ronald Norbert Hermeling, James Arthur Hoffmann, Chakravarthy Narasimhan
  • Patent number: 6358924
    Abstract: Methods and formulations are presented that provide for a) the oral absorption of GLP-1 peptides that bind surfactants; and b) long-term storage of formulations containing these peptides. For example, a GLP-1/DSS complex is administered orally instead of parenterally, which is much more convenient for, and facilitates compliance with diabetic patients and persons with other GLP-1 treated conditions.
    Type: Grant
    Filed: June 1, 2000
    Date of Patent: March 19, 2002
    Assignee: Eli Lilly and Company
    Inventor: James Arthur Hoffmann
  • Publication number: 20010014666
    Abstract: The invention provides individual tetragonal flat rod shaped or plate-like crystals of glucagon-like peptide-1 related molecules, processes for their preparation, compositions and methods of use. The crystal preparations exhibit extended time action in vivo and are useful for treating diabetes, obesity and related conditions.
    Type: Application
    Filed: December 11, 1998
    Publication date: August 16, 2001
    Inventors: RONALD NORBERT HERMELING, JAMES ARTHUR HOFFMANN, CHAKAVARTHY NARASIMHAN
  • Patent number: 5981488
    Abstract: The invention provides extended-action GLP-1 based peptides and compositions that are useful for treating diabetes and minimize the risk of hypoglycemia.
    Type: Grant
    Filed: March 25, 1998
    Date of Patent: November 9, 1999
    Assignee: Eli Lillly and Company
    Inventor: James Arthur Hoffmann
  • Patent number: 5831017
    Abstract: The present invention provides novel compounds, which comprise an obesity protein analog complexed with a divalent metal cation, pharmaceutical formulations thereof, and methods of using such compounds for treating obesity, and disorders associated with obesity such as diabetes, cardiovascular disease and cancer.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: November 3, 1998
    Assignee: Eli Lilly and Company
    Inventor: James Arthur Hoffmann
  • Patent number: RE41133
    Abstract: The invention provides individual tetragonal flat rod shaped or plate-like crystals of glucagon-like peptide-1 related molecules, processes for their preparation, compositions and methods of use. The crystal preparations exhibit extended time action in vivo and are useful for treating diabetes, obesity and related conditions.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: February 16, 2010
    Assignee: Eli Lilly and Company
    Inventors: Ronald Norbert Hermeling, James Arthur Hoffmann, Chakravarthy N. N. Narasimhan