Patents by Inventor James Arthur Holland

James Arthur Holland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prevention of atherosclerosis using NADPH oxidase inhibitors
    Patent number: 5902831
    Abstract: A method for the prevention and treatment of atherosclerosis and its related diseases in mammals, in which an NADPH oxidase inhibitor is administered, is provided. The NADPH oxidase inhibitor prevents the production of reactive oxygen species upon exposure of endothelial cells to atherogenic LDL levels, thus resulting in decreased endocytosis and vascular hyperpermeability. Preferred NADPH oxidase inhibitors are of the formula: ##STR1## Additionally, there is provided a diagnostic method for predicting risk of a human patient to atherosclerotic-related diseases.
    Type: Grant
    Filed: May 23, 1997
    Date of Patent: May 11, 1999
    Assignee: The Research Foundation of State University of New York
    Inventors: James Arthur Holland, David K. Johnson
  • Prevention of atherosclerosis using NADPH oxidase inhibitors
    Patent number: 5763496
    Abstract: A method for the prevention and treatment of atherosclerosis and its related diseases in mammals is provided, in which an NADPH oxidase inhibitor is administered to mammals. The NADPH oxidase inhibitor prevents the production of reactive oxygen species upon exposure of endothelial cells to atherogenic LDL levels, resulting in decreased endocytosis and vascular hyperpermeability. Apocynin is a preferred NADPH oxidase inhibitor. Additionally, there is provided a diagnostic method for predicting the risk to an individual of atherosclerotic-related diseases.
    Type: Grant
    Filed: November 27, 1995
    Date of Patent: June 9, 1998
    Assignee: The Research Foundation of State University of New York
    Inventor: James Arthur Holland