Abstract: A system and method for monitoring of and managing compliance with treatment for obstructive sleep apnea using oral appliance therapy comprises a sensor module installed in an oral appliance, a data communications facility for communicating with the oral appliance, a control module, and a central database for storing data. Data stored on the sensor module is transferred to the data communications facility for local storage. The control module validates the locally stored temperature data and uploads the validated data into the central database. Temperature data stored in the central database may be viewed remotely via a secure computer network connection in graphical form by authorized users using role-based access controls. Authorized users may include the patient, the patient's provider, system administrators, and stake holders including insurance carriers providing medical coverage for OAT.