Abstract: Chemically induced dimerizers (AbCIDs) have emerged as one of the most powerful tools to artificially regulate signaling pathways in cells; however, no facile method to identify or design these systems currently exists. The present invention provides a methodology to rapidly generate antibody-based chemically induced dimerizers (AbCIDs) from known small-molecule-protein complexes by selecting for synthetic antibodies that recognize the chemical epitope created by the bound small molecule. Success of this strategy is demonstrated by generating ten chemically-inducible antibodies against the BCL-xL/ABT-737 complex. Three of the antibodies are highly selective for the BCL-xL/ABT-737 complex over BCL-xL alone. Two exemplary important cellular applications of AbCIDs are demonstrated by applying them intracellularly to induce CRISPRa-mediated gene expression and extracellularly to regulate CAR T-cell activation with the small molecule, ABT-737.

Abstract: An article dispensing apparatus is described. The dispensing apparatus includes a plurality of slats, each having one or more holders for holding and dispensing articles. Each slat has a cavity and an open end. Further, each holder includes an aperture through which a pin may extend into and retract from the cavity to assist in dispensing articles held therein. Each open end may include a curved surface to assist in inhibiting the articles from being dispensed prematurely. Further, each slat may include a tongue on one side and a groove on another side. The tongues of each slat fit within the grooves of adjacent slats, allowing them to ride in close conformity to each other and allowing for relatively unencumbered movement between the slats.

Abstract: A fully integrated computer rack mount system comprising: at least one shelving unit configured to store computers; at least one electrical panel coupled to at least one of the at least one shelving unit, the at least one electrical panel configured to receive power from an external source; at least one network panel, coupled to at least one of the at least one shelving units, the at least one network panel configured to receive network connectivity from an outside source; a raceway apparatus coupled to the back plane or the front-plane of each of the at least one shelving unit, the raceway apparatus comprising a horizontal raceway and a vertical member, said vertical member comprising a power interface and a network interface; where said raceway apparatus is configured to allow each computer stored in the shelving units to be proximately connectable to the power interface and network interface; where the at least one electrical panel is coupled via said horizontal raceway to each power interface; and where t

Abstract: An article dispensing apparatus is described. The dispensing apparatus includes a plurality of slats, each having one or more holders for holding and dispensing articles. Each slat has a cavity and an open end. Further, each holder includes an aperture through which a pin may extend into and retract from the cavity to assist in dispensing articles held therein. Each open end may include a curved surface to assist in inhibiting the articles from being dispensed prematurely. Further, each slat may include a tongue on one side and a groove on another side. The tongues of each slat fit within the grooves of adjacent slats, allowing them to ride in close conformity to each other and allowing for relatively unencumbered movement between the slats.

Abstract: An article dispensing apparatus is described. The dispensing apparatus includes a plurality of slats, each having one or more holders for holding and dispensing articles. Each slat has a cavity and an open end. Further, each holder includes an aperture through which a pin may extend into and retract from the cavity to assist in dispensing articles held therein. Each open end may include a curved surface to assist in inhibiting the articles from being dispensed prematurely. Further, each slat may include a tongue on one side and a groove on another side. The tongues of each slat fit within the grooves of adjacent slats, allowing them to ride in close conformity to each other and allowing for relatively unencumbered movement between the slats.

Abstract: A method of pretreating and hot-dip coating aluminum or aluminum alloys on a chromium-containing steel strip to provide an improved coating comprising annealing final gauge steel strip in an oxygen excess atmosphere to produce a chromium-rich oxide on the surface and thereafter electrolytically descaling the strip in an aqueous salt solution to remove the oxide and to expose a chromium depleted surface of the strip. The strip is then transported to a coating line where it is heated to a temperature at or above the temperature of a bath of aluminum or aluminum alloy. A substantially hydrogen atmosphere is maintained over the bath while the dew point is maintained below minus 35.degree. C. The strip is then drawn through the bath to coat the strip.

Abstract: A weldable ferritic stainless steel and a method for producing the same is provided wherein the steel consists essentially of up to 0.03 carbon, up to 0.05 nitrogen, 10 to 25 chromium, up to 1.0 manganese, up to 0.5 nickel, up to 1.0 silicon, 0.03 to 0.35 titanium, 0.10 to 1.0 niobium, optionally up to 1.2 aluminum, the balance essentially iron, the amounts of titanium and niobium varying inversely and not more than necessary to satisfy specific thermodynamic equations and the method includes casting the steel into ingots or slabs without the precipitation of detrimental intermetallic or nonmetallic titanium compounds so that the hot-rolled band gauge, without grinding, can be cold rolled to final gauge sheet or strip free of open surface defects.

Abstract: A brake press including a stationary bar, a translating bar, a disk rotatable about a fixed, stationary axis, a first set of linkage interconnecting one longitudinal end of the translating bar with the disk, and a second set of linkage interconnecting the other longitudinal end of the translating bar with the disk. The rotation of the disk in a first direction acts through both sets of linkage to translate the translating bar toward the stationary bar, and the rotation of the disk in a second direction acts through both sets of linkage to translate the translating bar away from the stationary bar. The disk may be selectively rotated in either direction or maintained in a stationary position by one or more hydraulic rams. The flow of hydraulic fluid to the hydraulic rams is controlled by a foot pedal which is biased in a position which will cause the hydraulic rams to rotate the disk so that the translating bar is moved away from the stationary bar.

Abstract: A weldable ferritic stainless steel and a method for producing the same is provided wherein the steel consists essentially of up to 0.03 carbon, up to 0.05 nitrogen, 10 to 25 chromium, up to 1.0 manganese, up to 0.5 nickel, up to 1.0 silicon, 0.03 to 0.35 titanium, 0.10 to 1.0 niobium, optionally up to 1.2 aluminum, the balance essentially iron, the amounts of titanium and niobium varying inversely and not more than necessary to satisfy specific thermodynamic equations and the method includes casting the steel into ingots or slabs without the precipitation of detrimental intermetallic or nonmetallic titanium compounds so that the hot-rolled band gauge, without grinding, can be cold rolled to final gauge sheet or strip free of open surface defects.

Abstract: A container filling machine having a parallel series of elongated slats for movement in a closed path in a direction generally transverse to their length. The slats have cavities carrying articles such as capsules, tablets, caplets, etc. and deliver the same to a first set of horizontally extending chutes which in turn deliver the same to a second set of chutes there beneath. The first set of chutes is fixed with the second set of chutes being adapted for a "shuttle" or reciprocating movement so as to alternately deliver the articles to first and second rows of containers therebeneath. An associated conveyor has single and double container sections with a gate which alternately directs the containers to the first and second rows of containers in the double row section. Similarly, a pair of lead screws at the container filling station alternately assist in delivery, hold the containers in position for filling and thereafter discharge the filled containers.

Abstract: A substantially austenitic stainless steel is provided which is characterized by increased strength resulting from martensite formation upon cold working; the stainless steel consists essentially of, in weight percent, 0.08 max. carbon, 0.25 max. nitrogen, 12 to 15 chromium, 6.5 to 8.5 manganese, about 2 to 3.5 nickel, the sum of manganese and nickel being at least 9.0, and balance iron. The steel is further characterized by having less than 15% ferromagnetic phases in the cast and hot-processed conditions.A method of producing the steel product including hot working the steel alloy to a thickness which allows cold working by an amount equivalent to up to 25% thickness reduction and cold working without an intermediate anneal is also provided.

Abstract: Apparatus for carrying an infant on and by the body of an adult comprising one piece of conformable cloth-like material having a shoulder strap attached to the upper edge thereof and a waist strap attached to the lower edge thereof whereby the cloth-like material has a J-shape configuration when placed about an infant supported thereon.

Abstract: A structure for the support of equipment which may be struck by a moving body, the structure comprising a plurality of relatively rigid members and a plurality of frangibly connected joints connecting the plurality of relatively rigid members, each frangibly connected joint including a frangible region oriented with its longitudinal axis in the horizontal direction, the frangible region comprising a relatively brittle material of high strength, wherein the yield point of the material and its ultimate tensile strength are relatively close, to primarily shear under extraordinary loads when applied close to the frangible region but to fail under the combined action of shear and normal stress when loads are applied to the rigid members remote the frangible region, whereby the frangible joints receiving forces transmitted thereto after impact by a moving body with the structure will fail partially or completely and in the event of partial failure, will transmit the remaining forces to at least a second frangible j