Patents by Inventor James B. Jaquith
James B. Jaquith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9796716Abstract: The present invention relates to a novel family of inhibitors of protein kinases. In particular, the present invention relates to inhibitors of the members of the Tec and Src protein kinase families.Type: GrantFiled: May 28, 2013Date of Patent: October 24, 2017Assignee: PHARMASCIENCE, INC.Inventors: Alain Laurent, Yannick Rose, James B. Jaquith
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Patent number: 9284350Abstract: A compound of Formula 1: (I) or salt thereof, as well as methods of making compounds of Formula 1, methods of using compounds of Formula 1 to treat proliferative disorders such as cancer, and related compounds, composition, and methods.Type: GrantFiled: February 11, 2011Date of Patent: March 15, 2016Assignee: Pharmascience Inc.Inventors: Alain Laurent, Melanie Proulx, Yannick Rose, Irina Denissova, Kenza Dairi, Scott Jarvis, James B. Jaquith
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Publication number: 20150191473Abstract: The present invention relates to a novel family of inhibitors of protein kinases. In particular, the present invention relates to inhibitors of the members of the Tec and Src protein kinase families.Type: ApplicationFiled: May 28, 2013Publication date: July 9, 2015Applicant: Pharmascience, Inc.Inventors: Alain Laurent, Yannick Rose, James B. Jaquith
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Patent number: 8575113Abstract: The present invention is directed towards an isomer, an enantiomer, a diastereoisomer, or a tautomer of a pyrrolidine compound represented by Formula I: in which the substituents R1, R1a, R2, R2a, R3, A and Q are defined herein; or a prodrug, or a salt thereof, and which bind to IAP BIR domains. In particular, the compounds are useful in treating proliferative disorders such as cancer.Type: GrantFiled: June 28, 2010Date of Patent: November 5, 2013Assignee: Pharmascience Inc.Inventors: Scott Jarvis, Alain Boudreault, Patrick Bureau, James B. Jaquith, Alain Laurent, Delphine Labit
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Publication number: 20130040892Abstract: A compound of Formula 1: (I) or salt thereof, as well as methods of making compounds of Formula 1, methods of using compounds of Formula 1 to treat proliferative disorders such as cancer, and related compounds, composition, and methods.Type: ApplicationFiled: February 11, 2011Publication date: February 14, 2013Applicant: PHARMASCIENCE INC.Inventors: Alain Laurent, Melanie Proulx, Yannick Rose, Irina Denissova, Kenza Dairi, Scott Jarvis, James B. Jaquith
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Publication number: 20120009141Abstract: A compound of Formula 1: or a salt thereof, and methods for the use thereof, especially as an IAP inhibitor, as well as related compounds, compositions, and methods.Type: ApplicationFiled: August 7, 2009Publication date: January 12, 2012Applicant: PHARMASCIENCE INC.Inventors: Alain Laurent, Melanie Proulx, James B. Jaquith, Irina Denissova
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Publication number: 20110171171Abstract: A compound of Formula 1.1A: 1.1A or salt thereof, as well as methods of making compounds of Formula 1.1A, methods of using compounds of Formula 1.1A to treat proliferative disorders such as cancer, and related compounds, composition, and methods.Type: ApplicationFiled: June 26, 2009Publication date: July 14, 2011Applicant: Aegera Therapeutics, Inc.Inventors: Alain Laurent, Melanie Proulx, Yannick Rose, James B. Jaquith, Stephen Morris
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Patent number: 7772260Abstract: This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems.Type: GrantFiled: April 6, 2006Date of Patent: August 10, 2010Assignee: Aegera Therapeutics Inc.Inventors: James B. Jaquith, Gerald Villeneuve, Alain Boudreault, Stephen J. Morris, Jon Durkin, John W. Gillard, Kimberley E. Hewitt, H. Nicholas Marsh
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Patent number: 7741349Abstract: This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems.Type: GrantFiled: April 5, 2006Date of Patent: June 22, 2010Assignee: Aegera Therapeutics Inc.Inventors: James B. Jaquith, Gerald Villeneuve, Alain Boudreault, Stephen J. Morris, Jon Durkin, John W. Gillard, Kimberley Hewitt, H. Nicholas Marsh
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Patent number: 7714003Abstract: This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems.Type: GrantFiled: May 7, 2007Date of Patent: May 11, 2010Assignee: Aegera Therapeutics Inc.Inventors: James B. Jaquith, Alain Boudreault, Stephen J. Morris, Jon Durkin, John W. Gillard, Kimberley E. Hewitt
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Patent number: 7700635Abstract: This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems.Type: GrantFiled: May 7, 2007Date of Patent: April 20, 2010Assignee: Aegera Therapeutics Inc.Inventor: James B. Jaquith
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Patent number: 7645741Abstract: Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I or II or a salt thereof, in which R1, R2, R3, R100, R200, R300, A, A1, BG, Q and Q1 are substituents described herein. Also disclosed is the use of compounds of Formula I and II to treat proliferative disorders such as cancer.Type: GrantFiled: November 1, 2007Date of Patent: January 12, 2010Assignee: Aegera Therapeutics, Inc.Inventors: Alain Boudreault, James B. Jaquith, Patrick Bureau, John W. Gillard, Alain Laurent
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Patent number: 7579320Abstract: Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I or II or a salt thereof, in which R1, R2, R3, R100, R200, R300, A, A1, BG, Q and Q1 are substituents described herein. Also disclosed is the use of compounds of Formula I and II to treat proliferative disorders such as cancer.Type: GrantFiled: March 16, 2007Date of Patent: August 25, 2009Assignee: Aegera Therapeutics, Inc.Inventors: Alain Boudreault, James B. Jaquith, Alain Laurent
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Publication number: 20090179638Abstract: Disclosed is an assay for identifying compounds that modulate a neuronal apoptotic pathway, the assay comprises: a) contacting HSP90 protein with a probe to form a probe: HSP90 complex, the probe being displaceable by a test compound; b) measuring a signal from the probe so as to establish a reference level; c) incubating the probe:HSP90 complex with the test compound; d) measuring the signal from the probe; e) comparing the signal from step d) with the reference level, a modulation of the signal indicating that the test compound binds to HSP90. Also disclosed is a probe which is labeled with a detectable label and/or an affinity tag.Type: ApplicationFiled: February 1, 2007Publication date: July 16, 2009Applicant: AEGERA THERAPEUTICS INC.Inventors: Philip A. Barker, James B. Jaquith, Stephen J. Morris, Amir Salehi
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Publication number: 20090042953Abstract: This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems.Type: ApplicationFiled: April 7, 2008Publication date: February 12, 2009Applicant: AEGERA THERAPEUTICS, INC.Inventors: James B. JAQUITH, Gerald VILLENEUVE, Alain BOUDREAULT, Stephen J. MORRIS, Jon DURKIN, John W. GILLARD, Kimberley E. HEWITT, H. Nicholas MARSH
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Publication number: 20080207525Abstract: Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I or II or a salt thereof, in which R1, R2, R3, R100, R200, R300, A, A1, BG, Q and Q1 are substituents described herein. Also disclosed is the use of compounds of Formula I and II to treat proliferative disorders such as cancer.Type: ApplicationFiled: November 1, 2007Publication date: August 28, 2008Inventors: Alain Boudreault, James B. Jaquith, Patrick Bureau, John W. Gillard
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Patent number: 7230019Abstract: This invention relates to compounds of Formula (I) and the use of compounds of Formula (I) as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems.Type: GrantFiled: December 16, 2002Date of Patent: June 12, 2007Assignee: Aegera Therapeutics, Inc.Inventors: James B. Jaquith, Gerald Villeneuve, Alain Boudreault, Stephen Morris, Jon Durkin, John W. Gillard, Kimberly Hewitt, H. Nicholas Marsh
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Patent number: 7129250Abstract: This invention features ring-substituted pyrrolo-?-carboline derivatives and ring-substitution and structural derivatives of 3-(1H-indol-3-yl)-1H-pyrrole-2,5-dione of formulas I–III, which are useful as neuroprotective and anti-proliferative compounds. Also disclosed are methods for the preparation of these compounds, selected biological profiles and uses of these compounds in the treatment of various neurodegenerative and inflammatory diseases of the human nervous system and in the treatment of various other proliferative disorders characterized by loss of growth or cellular differentiation control including, but not limited to, cancer and inflammation.Type: GrantFiled: August 11, 2003Date of Patent: October 31, 2006Assignee: Aegera Therapeutics Inc.Inventors: James B. Jaquith, Alexander Graham Fallis, John W. Gillard, Alain Laurent
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Publication number: 20040220202Abstract: This invention features ring-substituted pyrrolo-&bgr;-carboline derivatives and ring-substitution and structural derivatives of 3-(1H-indol-3-yl)-1H-pyrrole-2,5-dione of formulas I-III, which are useful as neuroprotective and anti-proliferative compounds. Also disclosed are methods for the preparation of these compounds, selected biological profiles and uses of these compounds in the treatment of various neurodegenerative and inflammatory diseases of the human nervous system and in the treatment of various other proliferative disorders characterized by loss of growth or cellular differentiation control including, but not limited to, cancer and inflammation.Type: ApplicationFiled: August 11, 2003Publication date: November 4, 2004Inventors: James B. Jaquith, Alexander Graham Fallis, John W. Gillard, Alain Laurent
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Publication number: 20040102467Abstract: This invention features ring-substituted pyrrolo-&bgr;-carboline derivatives and ring-substitution and structural derivatives of 3-(1H-indol-3-yl)-1H-pyrrole-2,5-dione of formulas (I-III), which are useful as neuroprotective and anti-proliferative compounds. Also disclosed are methods for the preparation of these compounds, selected biological profiles and uses of these compounds in the treatment of various neurodegenerative and inflammatory diseases of the human nervous system and in the treatment of various other proliferative disorders characterized by loss of growth or cellular differentiation control including, but not limited to, cancer and inflammation.Type: ApplicationFiled: October 23, 2003Publication date: May 27, 2004Inventors: James B Jaquith, Alex Fallis, John W Gillard