Patents by Inventor James B. McAlpine
James B. McAlpine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4918174Abstract: New compounds, tiacumicins, are produced by a microorganism belonging to the genus Dactylosporangium. The compounds are effective Gram-positive antibiotics.Type: GrantFiled: September 26, 1986Date of Patent: April 17, 1990Assignee: Abbott LaboratoriesInventors: James B. McAlpine, Marianna Jackson, James Karwowski
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Patent number: 4874748Abstract: DNA cloning shuttle vectors, including a cosmid shuttle vector, for E. coli and Streptomyces are disclosed. Specifically, disclosed shuttle vectors pAL7002 (NRRL B-18055) and pNJl (NRRL B-18054) contain an E. coli origin of replication, Streptomyces replication functions, and antibiotic resistance markers for both E. coli and Streptomyces. In addition, pNJl contains a cos sequence. Novel 2-norerythromycin antibiotics A, B, C, and D, which were produced in a strain Streptomyces erythreus 12693-240 (NRRL B-18053) transformed by pNJl bearing DNA from Streptomyces antibioticus, are also disclosed. The present invention also provides a method for producing novel antibiotics. This method for antibiotic production is applied to the transformation of a blocked mutant of S. erythreus with genomic DNA from S. antibioticus but may be more broadly applied to genes to antibiotic-producing strains transformed into cells which are blocked in the pathway for production of a different antibiotic.Type: GrantFiled: March 24, 1986Date of Patent: October 17, 1989Assignee: Abbott LaboratoriesInventors: Leonard Katz, James Tuan, James B. McAlpine
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Patent number: 4423210Abstract: Disclosed herein are fortimicin derivatives represented by the formula: ##STR1## wherein R.sub.z is a monocyclicaryloxycarbonyl amine protecting group, or is loweralkyl, hydroxyloweralkyl, loweracyl, hydroxyloweracyl, or a monocyclicaryloxycarbonyl-protected aminoloweralkyl, diaminoloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxy-loweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, aminoloweracyl, diaminoloweracyl, N-loweralkylaminoloweracyl, N,N-diloweralkylaminoloweracyl, or aminohydroxyloweracyl; R.sub.1 is hydroxy or loweracyloxy; R.sub.2 is hydrogen, hydroxy or --OR.sub.4, wherein R.sub.4 is tert-butyldimethylsilyl or thiocarbonylimidazoyl; or R.sub.1 and R.sub.2 can be taken together to form ##STR2## wherein R.sub.5 and R.sub.6 are loweralkyl; R.sub.3 is hydroxy or loweracyloxy; and z is a monocyclicaryloxycarbonyl amine protecting group. The compounds are useful as intermediates in the preparation of 3-demethoxyfortimicins.Type: GrantFiled: April 9, 1982Date of Patent: December 27, 1983Assignee: Abbott LaboratoriesInventors: James B. McAlpine, Ronald E. Carney
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Patent number: 4418193Abstract: An improved method of producing 2-epi-fortimicin A directly from fortimicin A by protecting the amine functions of fortimicin A, converting the N-protected fortimicin A to an intermediate of the formula: ##STR1## wherein L is a leaving group and Z is an amine-protecting group, reacting the intermediate (I) with a loweralkyl metal halide in N,N-dimethylformamide to form N-protected-2-epi-fortimicin A, and then hydrogenating the N-protected-2-epi-fortimicin A to obtain 2-epi-fortimicin A.Type: GrantFiled: April 9, 1982Date of Patent: November 29, 1983Assignee: Abbott LaboratoriesInventors: James B. McAlpine, Ronald E. Carney
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Patent number: 4282211Abstract: 1-Epi-2-deoxyfortimicin B and 4-N-derivatives thereof represented by the formula: ##STR1## wherein: R.sub.1 is hydrogen or loweralkyl and R.sub.2 is selected from the group consisting of loweralkyl, aminoloweralkyl, diaminoloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminoloweralkyl, acyl, aminoacyl, diaminoacyl, hydroxyacyl, hydroxy-substituted aminoacyl hydroxy-substituted diaminoacyl, N-loweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted-N-loweralkylaminoacyl or hydroxysubstituted N,N-diloweralkylaminoacyl with the limitation that R.sub.2 cannot be hydrogen glycyl, formylglycyl or hydantoyl, and the pharmaceutically acceptable salts thereof. The compounds are broad spectrum antibiotics.Type: GrantFiled: September 26, 1979Date of Patent: August 4, 1981Assignee: Abbott LaboratoriesInventors: James B. McAlpine, Ronald E. Carney
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Patent number: 4272626Abstract: A method of producing 1-epi-2-deoxyfortimicin A, key intermediates therefor and an improved process for synthesizing the key intermediate 1,2-di-epi-fortimicin A.Type: GrantFiled: September 26, 1979Date of Patent: June 9, 1981Assignee: Abbott LaboratoriesInventors: Ronald E. Carney, James B. McAlpine
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Patent number: 4239752Abstract: Derivatives of O-demethylseldomycin factor 5 represented by the following formula are provided: ##STR1## wherein: R is hydrogen or loweralkyl; R.sub.1 and R.sub.2 can be either hydrogen or hydroxy with the limitation that both R.sub.1 and R.sub.2 cannot be hydroxy; R.sub.3 is selected from the group consisting of hydrogen, loweralkyl, aminoloweralkyl, diaminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, or ##STR2## with the limitation that when R.sub.1 is hydroxy, R.sub.3 cannot be hydrogen when R is hydrogen; and R.sub.4 is selected from the group consisting of loweralkyl, aminoloweralkyl, diaminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, aminohydroxyloweralkyl and N-loweralkylaminohydroxyloweralkyl; and the pharmaceutically acceptable salts thereof. The compounds are potent anti-bacterial agents.Type: GrantFiled: March 29, 1979Date of Patent: December 16, 1980Assignee: Abbott LaboratoriesInventors: Ronald E. Carney, Robert L. Devault, James B. McAlpine, Arthur C. Sinclair
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Patent number: 4226979Abstract: A new fortimicin, fortimicin AK. The compound is coproduced in the fermentation of Micromonospora olivoasterospora ATCC No. 21819, 31009 or 31010 along with fortimicin A, fortimicin B isofortimicin, fortimicin E and a number of other minor factors. The compound is useful as an intermediate in synthesizing fortimicin AK derivatives which are useful as antibiotics.Type: GrantFiled: March 29, 1979Date of Patent: October 7, 1980Assignee: Abbott LaboratoriesInventor: James B. McAlpine
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Patent number: 4223024Abstract: 4"-O-alkylgentamicins and sagamicins represented by the formula: ##STR1## wherein R.sub.1 is hydrogen or methyl: R.sub.2 is hydrogen or methyl; R.sub.3 is hydrogen or hydroxy; R.sub.4 is hydroxy when R.sub.3 is hydrogen and hydrogen when R.sub.3 is hydroxy; and R.sub.5 is loweralkyl; and the pharmaceutically acceptable salts thereof, intermediates therefor, and compositions and methods employing the potent antibiotics of this invention.Type: GrantFiled: March 12, 1979Date of Patent: September 16, 1980Assignee: Abbott LaboratoriesInventors: James B. McAlpine, Robert L. DeVault
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Patent number: 4218442Abstract: A 1-Epi fortimicin represented by the formula ##STR1## wherein: R.sub.1 is hydrogen or loweralkyl; R.sub.2 is hydrogen or hydroxyl, R.sub.3 is selected from the group consisting of hydrogen, loweralkyl, aminoloweralkyl, diaminoloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, hydroxyloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, acyl, aminoacyl, diaminoacyl, hydroxyacyl, hydroxy-substituted aminoacyl, hydroxy-substituted diaminoacyl, N-loweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted N-loweralkylaminoacyl or hydroxy-substituted N,N-diloweralkylaminoacyl; R.sub.4 is hydrogen or methyl; and the pharmaceutically acceptable salts thereof.Type: GrantFiled: March 29, 1979Date of Patent: August 19, 1980Assignee: Abbott LaboratoriesInventors: James B. McAlpine, Ronald E. Carney
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Patent number: 4218441Abstract: A new seldomycin factor 5 derivative is provided, O-demethylseldomycin factor 5. The compound is represented by the formula: ##STR1## The compound is a potent anti-bacterial agent.Type: GrantFiled: March 29, 1979Date of Patent: August 19, 1980Assignee: Abbott LaboratoriesInventors: Ronald E. Carney, Robert L. DeVault, James B. McAlpine, Arthur C. Sinclair
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Patent number: 4216210Abstract: 4,N, 2'-N and 4,2'-Di-N-derivatives of fortimicin AM and fortimicin AP are provided by this invention. The compounds are useful as anti-bacterial agents.Type: GrantFiled: March 29, 1979Date of Patent: August 5, 1980Assignee: Abbott LaboratoriesInventors: Ronald E. Carney, James B. McAlpine
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Patent number: 4213971Abstract: Derivatives of fortimicin AK are provided by this invention. The derivatives are 4-N, 2'-N- and 4,2'-di-N-derivatives of fortimicin AK which are useful as anti-bacterial agents.Type: GrantFiled: March 29, 1979Date of Patent: July 22, 1980Assignee: Abbott LaboratoriesInventor: James B. McAlpine
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Patent number: 4214076Abstract: 2'-N-substituted fortimicin B and fortimicin B derivatives represented by the formula ##STR1## wherein: R is selected from the group consisting of .beta.-naphthoyl, .gamma.-naphthoyl, .gamma.-naphthyl, (.gamma.-amino-.gamma.-hydroxybutyryl) or 1-(2-amino-4-hydroxybutyl) and R.sub.1 is N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl or hydrogen and the pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of making and using the compounds. The compounds are useful as antibiotics.Type: GrantFiled: December 21, 1977Date of Patent: July 22, 1980Assignee: Abbott LaboratoriesInventor: James B. McAlpine
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Patent number: 4208407Abstract: 5-Deoxyfortimicin A, 2,5-dideoxyfortimicin A and the corresponding 4-N-acyl and alkyl fortimicin B derivatives thereof, pharmaceutically acceptable salts thereof, intermediates therefor, and pharmaceutical compositions containing the compounds of this invention. The fortimicin derivatives are represented by the formula: ##STR1## wherein R is selected from the group consisting of acyl, hydroxyacyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxyacyl, hydroxy-substituted aminoacyl or an amino acid residue other than glycyl, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-monoloweralkylaminoloweralkyl, N-N-diloweralkylaminoloweralkyl or hydroxy-substituted aminoloweralkyl; R.sub.1 is hydrogen or hydroxy; and R.sub.2 is hydrogen or hydroxy with the limitation that either R.sub.1 and R.sub.2 each are hydrogen or when only one of R.sub.1 or R.sub.2 are hydrogen, R.sub.2 is hydrogen and R.sub.1 is hydroxy and R.sub.1 and R.sub.2 both cannot be hydroxy.Type: GrantFiled: February 5, 1979Date of Patent: June 17, 1980Assignee: Abbott LaboratoriesInventors: Ronald E. Carney, Jerry R. Martin, James B. McAlpine, John S. Tadanier
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Patent number: 4207415Abstract: An improved method for producing the antibiotic 2-deoxyfortimicin A, the method comprising the process of producing said antibiotic directly from fortimicin A in a four step process which results in a 50-60 percent yield of product.Type: GrantFiled: February 5, 1979Date of Patent: June 10, 1980Assignee: Abbott LaboratoriesInventors: Ronald E. Carney, Jerry R. Martin, James B. McAlpine, John S. Tadanier
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Patent number: 4189569Abstract: Described are novel derivatives of seldomycin factor 5 (XK-88-5) and particularly 3'-Epi-seldomycin factor 5, which exhibit improved activity against gram-positive and gram-negative bacteria resistant to aminoglycoside antibiotics, and a method of preparing them.Type: GrantFiled: July 5, 1978Date of Patent: February 19, 1980Assignee: Abbott LaboratoriesInventors: Ronald E. Carney, James B. McAlpine
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Patent number: 4187372Abstract: Described are novel derivatives of seldomycin factor 5 (XK-88-5) and particularly 3'-deoxyseldomycin factor 5, which exhibit improved activity against gram-positive and gram-negative bacteria resistant to aminoglycoside antibiotics, and a method of preparing them.Type: GrantFiled: September 8, 1976Date of Patent: February 5, 1980Assignee: Abbott LaboratoriesInventors: Ronald E. Carney, James B. McAlpine, Thomas J. Perun