Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific irreversible inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL irreversible inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

Abstract: Disclosed herein are heterocyclic compounds, for example, according to the following formula and analogs thereof: that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.

Abstract: A telecommunications switching system with a hardware resource manager system. The resource manager interfaces with higher-level system functions such as call processing, OA&M, NMS and system control functions and with lower-level hardware functions embodied in an input/output sub-system (IOSS) containing various hardware resources for interfacing the switching system to other entities. The resource manager controls all interactions between the IOSS hardware and the higher-level functions and hides the hardware specifics of the IOSS, giving the higher-level functions a hardware-independent view of the IOSS resources. As a result, the higher-level functions can operate without modification with a wide variety of IOSS hardware configurations. The resource manager manages the physical interfaces and IOSS resources and is aware of the complete configuration of the IOSS, including all channel addressing information and the state of each IOSS resource.

Abstract: A system for providing control of redundant components is presented. The system includes two resource modules. The resource module is connected to a data bus, but only the active resource module has control of the data bus. Two call processor systems are connected to the resource modules, and the active call processor is connected to the active resource module. A call processor connection client operating on the resource module transmits a connection request message to the call processor systems. A call processor connection server operating on the call processor system can receive the connection request message and assign the resource module active status.